Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction

Acute myocardial infarction (AMI) triggers sterile inflammatory reaction mediated by prostaglandin E2 (PGE2). Tang et al. show that the PGE2 via its receptor EP3 promotes cardiac healing after AMI by recruiting reparative Ly6Clowmonocytes/macrophages, which is mediated by TGF-β-driven regulation of...

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Autores principales:	Juan Tang, Yujun Shen, Guilin Chen, Qiangyou Wan, Kai Wang, Jian Zhang, Jing Qin, Guizhu Liu, Shengkai Zuo, Bo Tao, Yu Yu, Junwen Wang, Michael Lazarus, Ying Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/37060ae553b64255adedfaa4d8078298
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spelling	oai:doaj.org-article:37060ae553b64255adedfaa4d80782982021-12-02T14:42:01ZActivation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction10.1038/ncomms146562041-1723https://doaj.org/article/37060ae553b64255adedfaa4d80782982017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14656https://doaj.org/toc/2041-1723Acute myocardial infarction (AMI) triggers sterile inflammatory reaction mediated by prostaglandin E2 (PGE2). Tang et al. show that the PGE2 via its receptor EP3 promotes cardiac healing after AMI by recruiting reparative Ly6Clowmonocytes/macrophages, which is mediated by TGF-β-driven regulation of CX3CR1 expression and VEGF secretion.Juan TangYujun ShenGuilin ChenQiangyou WanKai WangJian ZhangJing QinGuizhu LiuShengkai ZuoBo TaoYu YuJunwen WangMichael LazarusYing YuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Juan Tang Yujun Shen Guilin Chen Qiangyou Wan Kai Wang Jian Zhang Jing Qin Guizhu Liu Shengkai Zuo Bo Tao Yu Yu Junwen Wang Michael Lazarus Ying Yu Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction
description	Acute myocardial infarction (AMI) triggers sterile inflammatory reaction mediated by prostaglandin E2 (PGE2). Tang et al. show that the PGE2 via its receptor EP3 promotes cardiac healing after AMI by recruiting reparative Ly6Clowmonocytes/macrophages, which is mediated by TGF-β-driven regulation of CX3CR1 expression and VEGF secretion.
format	article
author	Juan Tang Yujun Shen Guilin Chen Qiangyou Wan Kai Wang Jian Zhang Jing Qin Guizhu Liu Shengkai Zuo Bo Tao Yu Yu Junwen Wang Michael Lazarus Ying Yu
author_facet	Juan Tang Yujun Shen Guilin Chen Qiangyou Wan Kai Wang Jian Zhang Jing Qin Guizhu Liu Shengkai Zuo Bo Tao Yu Yu Junwen Wang Michael Lazarus Ying Yu
author_sort	Juan Tang
title	Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction
title_short	Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction
title_full	Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction
title_fullStr	Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction
title_full_unstemmed	Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction
title_sort	activation of e-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/37060ae553b64255adedfaa4d8078298
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Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction

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