Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis

Background: Ulcerative colitis is acommontype of inflammatory bowel disease (IBD). The aim of the present study was to examinethe relationship between lipid profile, especially high-density lipoprotein (HDL), and malondialdehyde (MDA) level in patients withulcerative colitis.Methods: In this study,...

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Autores principales:	Mostafa Vaghari Tabari, Soheila Moein, Durdi Qujeq, Mehrdad Kashifard, Javaad Shokri Shirvani, Karimollah Hajian Tilaki, Gholamreza Farshidfar
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2017
Materias:	ulcerative colitis disease hdl-c level mda level active and inactive disease Medicine R
Acceso en línea:	https://doaj.org/article/37092a46cd1e4ec181e853dd9e49ad15
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spelling	oai:doaj.org-article:37092a46cd1e4ec181e853dd9e49ad152021-11-16T07:43:39ZEvaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis2783-2430https://doaj.org/article/37092a46cd1e4ec181e853dd9e49ad152017-06-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_47162_b432b23e976cf01c7696f22dd4cb4219.pdfhttps://doaj.org/toc/2783-2430Background: Ulcerative colitis is acommontype of inflammatory bowel disease (IBD). The aim of the present study was to examinethe relationship between lipid profile, especially high-density lipoprotein (HDL), and malondialdehyde (MDA) level in patients withulcerative colitis.Methods: In this study, 45 patients with ulcerative colitis were selected, 25 of whom were diagnosed with active disease and 20were in clinical remission. Moreover, 45 healthy subjects were selected as the controls. The status of serum lipid profile and MDAlevel were measured via precise photometric methods. The obtained data were analyzed, using independent t-test and correlationcoefficient test. P < 0.05 was considered statistically significant.Results: The serum level of HDL-C decreased, while the serum level of MDA significantly increased in patients with ulcerative colitisin comparison with the healthy controls (P < 0.05). No significant correlation was observed between theMDAlevel and triglyceride,cholesterol, and LDL-C levels in patients with ulcerative colitis. However, a significant inverse correlation was observed betweenHDL-C and MDA levels (r, -0.306; P < 0.05).Conclusions: The inverse correlation between HDL-C andMDAlevels can be regarded as an indicator of the protective role of HDL-Cagainst lipid peroxidation in ulcerative colitis. In patients with ulcerative colitis, the serum level of HDL-C decreased in comparisonwith healthy subjects. Therefore, it is necessary to determine the HDL-C level in patients with ulcerative colitis.Mostafa Vaghari TabariSoheila MoeinDurdi QujeqMehrdad KashifardJavaad Shokri ShirvaniKarimollah Hajian TilakiGholamreza FarshidfarShiraz University of Medical Sciencesarticleulcerative colitis diseasehdl-c levelmda levelactive and inactive diseaseMedicineRENIranian Journal of Colorectal Research, Vol 5, Iss Issues 3-4 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	ulcerative colitis disease hdl-c level mda level active and inactive disease Medicine R
spellingShingle	ulcerative colitis disease hdl-c level mda level active and inactive disease Medicine R Mostafa Vaghari Tabari Soheila Moein Durdi Qujeq Mehrdad Kashifard Javaad Shokri Shirvani Karimollah Hajian Tilaki Gholamreza Farshidfar Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis
description	Background: Ulcerative colitis is acommontype of inflammatory bowel disease (IBD). The aim of the present study was to examinethe relationship between lipid profile, especially high-density lipoprotein (HDL), and malondialdehyde (MDA) level in patients withulcerative colitis.Methods: In this study, 45 patients with ulcerative colitis were selected, 25 of whom were diagnosed with active disease and 20were in clinical remission. Moreover, 45 healthy subjects were selected as the controls. The status of serum lipid profile and MDAlevel were measured via precise photometric methods. The obtained data were analyzed, using independent t-test and correlationcoefficient test. P < 0.05 was considered statistically significant.Results: The serum level of HDL-C decreased, while the serum level of MDA significantly increased in patients with ulcerative colitisin comparison with the healthy controls (P < 0.05). No significant correlation was observed between theMDAlevel and triglyceride,cholesterol, and LDL-C levels in patients with ulcerative colitis. However, a significant inverse correlation was observed betweenHDL-C and MDA levels (r, -0.306; P < 0.05).Conclusions: The inverse correlation between HDL-C andMDAlevels can be regarded as an indicator of the protective role of HDL-Cagainst lipid peroxidation in ulcerative colitis. In patients with ulcerative colitis, the serum level of HDL-C decreased in comparisonwith healthy subjects. Therefore, it is necessary to determine the HDL-C level in patients with ulcerative colitis.
format	article
author	Mostafa Vaghari Tabari Soheila Moein Durdi Qujeq Mehrdad Kashifard Javaad Shokri Shirvani Karimollah Hajian Tilaki Gholamreza Farshidfar
author_facet	Mostafa Vaghari Tabari Soheila Moein Durdi Qujeq Mehrdad Kashifard Javaad Shokri Shirvani Karimollah Hajian Tilaki Gholamreza Farshidfar
author_sort	Mostafa Vaghari Tabari
title	Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis
title_short	Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis
title_full	Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis
title_fullStr	Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis
title_full_unstemmed	Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis
title_sort	evaluation of the potential antioxidant role of high-density lipoprotein-cholesterol (hdl-c) in patients with ulcerative colitis
publisher	Shiraz University of Medical Sciences
publishDate	2017
url	https://doaj.org/article/37092a46cd1e4ec181e853dd9e49ad15
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Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis

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