Oxytocin-induced anxiogenic behavior in juvenile male rats

Oxytocin (OT) is considered beneficial to mental health owing to its anxiolytic, prosocial, and anti-stress effects; however, the adverse effects of OT have been controversial, such as its potentially anxiogenic actions. Although OT influences drug abuse and reciprocally affects vulnerability to dru...

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Autores principales:	Minji Jang, Taesub Jung, Miseon Kang, Jeongyeon Kim, Jihyun Noh
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	anxiety emotional behavior nicotine aversion oxytocin stress Medicine (General) R5-920 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/370a30774e254934b7b4906f7dce6e5c
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spelling	oai:doaj.org-article:370a30774e254934b7b4906f7dce6e5c2021-11-04T15:00:43ZOxytocin-induced anxiogenic behavior in juvenile male rats1976-83542151-248510.1080/19768354.2021.1995485https://doaj.org/article/370a30774e254934b7b4906f7dce6e5c2021-10-01T00:00:00Zhttp://dx.doi.org/10.1080/19768354.2021.1995485https://doaj.org/toc/1976-8354https://doaj.org/toc/2151-2485Oxytocin (OT) is considered beneficial to mental health owing to its anxiolytic, prosocial, and anti-stress effects; however, the adverse effects of OT have been controversial, such as its potentially anxiogenic actions. Although OT influences drug abuse and reciprocally affects vulnerability to drug use, the relationship between OT’s anxiogenic working and nicotine preference intake has not been clearly defined. To clarify this issue, the effect of acute peripheral administration of OT on anxiety and nicotine preference was investigated in juvenile male rats. Anxiogenic behaviors were noticeably increased in OT-administrated rats, with an increase in serum corticosterone levels. Moreover, increased anxiety-like behaviors and corticosterone levels were observed in the OT analog carbetocin-injected rats. In the nicotine preference test, the rats’ aversive responses to initial nicotine choice and preference were not significantly different between saline-injected and OT-injected rats. However, when administered with OT, there was a significant negative correlation between anxiety-like behavior and low-dose nicotine consumption. Collectively, these results provide evidence that acute OT exposure could induce anxiogenic behavior with corticosterone augmentation, contributing to the attenuation of nicotine preference. This suggests that both aspects of OT, as well as their benefits and drawbacks, should be considered.Minji JangTaesub JungMiseon KangJeongyeon KimJihyun NohTaylor & Francis Grouparticleanxietyemotional behaviornicotine aversionoxytocinstressMedicine (General)R5-920Biology (General)QH301-705.5ENAnimal Cells and Systems, Vol 0, Iss 0, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anxiety emotional behavior nicotine aversion oxytocin stress Medicine (General) R5-920 Biology (General) QH301-705.5
spellingShingle	anxiety emotional behavior nicotine aversion oxytocin stress Medicine (General) R5-920 Biology (General) QH301-705.5 Minji Jang Taesub Jung Miseon Kang Jeongyeon Kim Jihyun Noh Oxytocin-induced anxiogenic behavior in juvenile male rats
description	Oxytocin (OT) is considered beneficial to mental health owing to its anxiolytic, prosocial, and anti-stress effects; however, the adverse effects of OT have been controversial, such as its potentially anxiogenic actions. Although OT influences drug abuse and reciprocally affects vulnerability to drug use, the relationship between OT’s anxiogenic working and nicotine preference intake has not been clearly defined. To clarify this issue, the effect of acute peripheral administration of OT on anxiety and nicotine preference was investigated in juvenile male rats. Anxiogenic behaviors were noticeably increased in OT-administrated rats, with an increase in serum corticosterone levels. Moreover, increased anxiety-like behaviors and corticosterone levels were observed in the OT analog carbetocin-injected rats. In the nicotine preference test, the rats’ aversive responses to initial nicotine choice and preference were not significantly different between saline-injected and OT-injected rats. However, when administered with OT, there was a significant negative correlation between anxiety-like behavior and low-dose nicotine consumption. Collectively, these results provide evidence that acute OT exposure could induce anxiogenic behavior with corticosterone augmentation, contributing to the attenuation of nicotine preference. This suggests that both aspects of OT, as well as their benefits and drawbacks, should be considered.
format	article
author	Minji Jang Taesub Jung Miseon Kang Jeongyeon Kim Jihyun Noh
author_facet	Minji Jang Taesub Jung Miseon Kang Jeongyeon Kim Jihyun Noh
author_sort	Minji Jang
title	Oxytocin-induced anxiogenic behavior in juvenile male rats
title_short	Oxytocin-induced anxiogenic behavior in juvenile male rats
title_full	Oxytocin-induced anxiogenic behavior in juvenile male rats
title_fullStr	Oxytocin-induced anxiogenic behavior in juvenile male rats
title_full_unstemmed	Oxytocin-induced anxiogenic behavior in juvenile male rats
title_sort	oxytocin-induced anxiogenic behavior in juvenile male rats
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/370a30774e254934b7b4906f7dce6e5c
work_keys_str_mv	AT minjijang oxytocininducedanxiogenicbehaviorinjuvenilemalerats AT taesubjung oxytocininducedanxiogenicbehaviorinjuvenilemalerats AT miseonkang oxytocininducedanxiogenicbehaviorinjuvenilemalerats AT jeongyeonkim oxytocininducedanxiogenicbehaviorinjuvenilemalerats AT jihyunnoh oxytocininducedanxiogenicbehaviorinjuvenilemalerats
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Oxytocin-induced anxiogenic behavior in juvenile male rats

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