Association Between Glutathione Peroxidase-1 (GPx-1) Polymorphisms and Schizophrenia in the Chinese Han Population

Xiaojun Shao1 *,* Ci Yan1 *,* Dongxue Sun,1 Chunfeng Fu,1 Chunsheng Tian,1 Li Duan,1 Gang Zhu1,2 1Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 2Central Laboratory, The First Affiliated Hospital of China Me...

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Autores principales:	Shao X, Yan C, Sun D, Fu C, Tian C, Duan L, Zhu G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	case-control study chinese-han population gpx1 polymorphism schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/370c26310d854ddfbe4c1fa1876054bf
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spelling	oai:doaj.org-article:370c26310d854ddfbe4c1fa1876054bf2021-12-02T11:35:50ZAssociation Between Glutathione Peroxidase-1 (GPx-1) Polymorphisms and Schizophrenia in the Chinese Han Population1178-2021https://doaj.org/article/370c26310d854ddfbe4c1fa1876054bf2020-10-01T00:00:00Zhttps://www.dovepress.com/association-between-glutathione-peroxidase-1-gpx-1-polymorphisms-and-s-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xiaojun Shao1 , Ci Yan1 , Dongxue Sun,1 Chunfeng Fu,1 Chunsheng Tian,1 Li Duan,1 Gang Zhu1,2 1Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 2Central Laboratory, The First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gang ZhuDepartment of Psychiatry, Tthe First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of ChinaTel/ Fax +86-24-83282184Email gzhu@cmu.edu.cnObjective: The dopamine and oxidative stress hypotheses are leading theories of the pathoetiology of schizophrenia (SCZ). Glutathione Peroxidase 1 (GPx-1), a major antioxidant enzyme, and the most abundantly expressed member of the GPx family, plays an important role in metabolic dopamine changes, which are closely related to neurological and psychiatric disorders. The impact of GPx-1 polymorphisms has rarely been explored in the field of SCZ. Here, we explored the possible relationship between GPx-1 gene polymorphisms and SCZ in Chinese Han subjects by using the polymerase chain reaction-restriction fragment length polymorphism method.Methods: DNA from 786 patients (360 patients with schizophrenia and 426 healthy controls) was genotyped for the single-nucleotide polymorphisms rs1800668 C/T and rs1050450 C/T in GPx-1 using polymerase chain reaction-restriction fragment length polymorphism analysis. Analysis of the association between GPx-1 and SCZ was performed using SPSS 22.0, while Haploview 4.2 software and SHEsis software were used to perform linkage disequilibrium analysis and haplotype analysis.Results: The results indicated that the GPx-1 polymorphisms rs1050450 and rs1800668 were associated with SCZ. We found that the C-allele of rs1800668 C/T may be a protection factor against SCZ in general, but in particular, for males. Furthermore, the CT and TC (GPx-1 rs1800668 C/T and rs1050450 C/T) haplotypes may be susceptible to SCZ in the population. Finally, no significant differences in allelic or genotypic frequencies of rs1050450 were detected between cases and controls from whole or stratification analyses by gender.Conclusion: GPx-1 polymorphisms are related to SCZ in Chinese Han subjects. Our results suggested that GPx-1 may be a potential gene that influences SCZ.Keywords: case-control study, Chinese Han population, GPx1, polymorphism, schizophreniaShao XYan CSun DFu CTian CDuan LZhu GDove Medical Pressarticlecase-control studychinese-han populationgpx1polymorphismschizophreniaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 2297-2305 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	case-control study chinese-han population gpx1 polymorphism schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	case-control study chinese-han population gpx1 polymorphism schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Shao X Yan C Sun D Fu C Tian C Duan L Zhu G Association Between Glutathione Peroxidase-1 (GPx-1) Polymorphisms and Schizophrenia in the Chinese Han Population
description	Xiaojun Shao1 , Ci Yan1 , Dongxue Sun,1 Chunfeng Fu,1 Chunsheng Tian,1 Li Duan,1 Gang Zhu1,2 1Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 2Central Laboratory, The First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gang ZhuDepartment of Psychiatry, Tthe First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of ChinaTel/ Fax +86-24-83282184Email gzhu@cmu.edu.cnObjective: The dopamine and oxidative stress hypotheses are leading theories of the pathoetiology of schizophrenia (SCZ). Glutathione Peroxidase 1 (GPx-1), a major antioxidant enzyme, and the most abundantly expressed member of the GPx family, plays an important role in metabolic dopamine changes, which are closely related to neurological and psychiatric disorders. The impact of GPx-1 polymorphisms has rarely been explored in the field of SCZ. Here, we explored the possible relationship between GPx-1 gene polymorphisms and SCZ in Chinese Han subjects by using the polymerase chain reaction-restriction fragment length polymorphism method.Methods: DNA from 786 patients (360 patients with schizophrenia and 426 healthy controls) was genotyped for the single-nucleotide polymorphisms rs1800668 C/T and rs1050450 C/T in GPx-1 using polymerase chain reaction-restriction fragment length polymorphism analysis. Analysis of the association between GPx-1 and SCZ was performed using SPSS 22.0, while Haploview 4.2 software and SHEsis software were used to perform linkage disequilibrium analysis and haplotype analysis.Results: The results indicated that the GPx-1 polymorphisms rs1050450 and rs1800668 were associated with SCZ. We found that the C-allele of rs1800668 C/T may be a protection factor against SCZ in general, but in particular, for males. Furthermore, the CT and TC (GPx-1 rs1800668 C/T and rs1050450 C/T) haplotypes may be susceptible to SCZ in the population. Finally, no significant differences in allelic or genotypic frequencies of rs1050450 were detected between cases and controls from whole or stratification analyses by gender.Conclusion: GPx-1 polymorphisms are related to SCZ in Chinese Han subjects. Our results suggested that GPx-1 may be a potential gene that influences SCZ.Keywords: case-control study, Chinese Han population, GPx1, polymorphism, schizophrenia
format	article
author	Shao X Yan C Sun D Fu C Tian C Duan L Zhu G
author_facet	Shao X Yan C Sun D Fu C Tian C Duan L Zhu G
author_sort	Shao X
title	Association Between Glutathione Peroxidase-1 (GPx-1) Polymorphisms and Schizophrenia in the Chinese Han Population
title_short	Association Between Glutathione Peroxidase-1 (GPx-1) Polymorphisms and Schizophrenia in the Chinese Han Population
title_full	Association Between Glutathione Peroxidase-1 (GPx-1) Polymorphisms and Schizophrenia in the Chinese Han Population
title_fullStr	Association Between Glutathione Peroxidase-1 (GPx-1) Polymorphisms and Schizophrenia in the Chinese Han Population
title_full_unstemmed	Association Between Glutathione Peroxidase-1 (GPx-1) Polymorphisms and Schizophrenia in the Chinese Han Population
title_sort	association between glutathione peroxidase-1 (gpx-1) polymorphisms and schizophrenia in the chinese han population
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/370c26310d854ddfbe4c1fa1876054bf
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Association Between Glutathione Peroxidase-1 (GPx-1) Polymorphisms and Schizophrenia in the Chinese Han Population

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