FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY

To evaluate the immunity indexes in the children who were born with bronchopulmonary dysplasia (BPD) of varying severity at very early delivery terms (22-27 weeks), dynamic examinations were performed in 35 infants: 17 children were with severe BPD; 18, with mild-severity and moderately severe BPD....

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Autores principales:	G. N. Chistyakova, I. I. Remizova, L. S. Ustyantseva, K. P. Shamova, S. V. Bychkova, M. A. Botskovskaya, I. A. Gazieva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	extremely low body weight bronchopulmonary dysplasia adaptive immunity innate immunity Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/370d09e41d704fc8a10ab3e3fa31f2cd
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spelling	oai:doaj.org-article:370d09e41d704fc8a10ab3e3fa31f2cd2021-11-18T08:03:48ZFEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY1563-06252313-741X10.15789/1563-0625-2019-3-517-526https://doaj.org/article/370d09e41d704fc8a10ab3e3fa31f2cd2019-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1825https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XTo evaluate the immunity indexes in the children who were born with bronchopulmonary dysplasia (BPD) of varying severity at very early delivery terms (22-27 weeks), dynamic examinations were performed in 35 infants: 17 children were with severe BPD; 18, with mild-severity and moderately severe BPD. The comparison group consisted of seven children born at 22-27 weeks of gestational age without signs of BPD. Relative numbers of lymphocyte subpopulations (CD3+, CD4+, CD8+, CD19+, CD16+CD56+, CD4+CD25+), and monocytes (CD14+CD64+, CD14+HLA-DR+) were determined by flow cytometry. The level of cytokines (IL-6, IL-8, IL-4) was measured by enzyme immunoassay technique. The features of immune status in children with BPD of severe, mild and moderate severity were discerned. It was found that the predictors of severe BPD development in the children born at very early terms, are: increased content of IL-8 at birth and at the age of 1 month, reduced level of expression on monocytes (CD64, HLA-DR) on the 1 month of life, and CD14+CD64+ cells at 38-40 weeks post conception. The revealed features of immune status in newborns with BPD can be used to assess the effectiveness of the therapy, which requires further research in this direction.G. N. ChistyakovaI. I. RemizovaL. S. UstyantsevaK. P. ShamovaS. V. BychkovaM. A. BotskovskayaI. A. GazievaSPb RAACIarticleextremely low body weightbronchopulmonary dysplasiaadaptive immunityinnate immunityImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 3, Pp 517-526 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	extremely low body weight bronchopulmonary dysplasia adaptive immunity innate immunity Immunologic diseases. Allergy RC581-607
spellingShingle	extremely low body weight bronchopulmonary dysplasia adaptive immunity innate immunity Immunologic diseases. Allergy RC581-607 G. N. Chistyakova I. I. Remizova L. S. Ustyantseva K. P. Shamova S. V. Bychkova M. A. Botskovskaya I. A. Gazieva FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY
description	To evaluate the immunity indexes in the children who were born with bronchopulmonary dysplasia (BPD) of varying severity at very early delivery terms (22-27 weeks), dynamic examinations were performed in 35 infants: 17 children were with severe BPD; 18, with mild-severity and moderately severe BPD. The comparison group consisted of seven children born at 22-27 weeks of gestational age without signs of BPD. Relative numbers of lymphocyte subpopulations (CD3+, CD4+, CD8+, CD19+, CD16+CD56+, CD4+CD25+), and monocytes (CD14+CD64+, CD14+HLA-DR+) were determined by flow cytometry. The level of cytokines (IL-6, IL-8, IL-4) was measured by enzyme immunoassay technique. The features of immune status in children with BPD of severe, mild and moderate severity were discerned. It was found that the predictors of severe BPD development in the children born at very early terms, are: increased content of IL-8 at birth and at the age of 1 month, reduced level of expression on monocytes (CD64, HLA-DR) on the 1 month of life, and CD14+CD64+ cells at 38-40 weeks post conception. The revealed features of immune status in newborns with BPD can be used to assess the effectiveness of the therapy, which requires further research in this direction.
format	article
author	G. N. Chistyakova I. I. Remizova L. S. Ustyantseva K. P. Shamova S. V. Bychkova M. A. Botskovskaya I. A. Gazieva
author_facet	G. N. Chistyakova I. I. Remizova L. S. Ustyantseva K. P. Shamova S. V. Bychkova M. A. Botskovskaya I. A. Gazieva
author_sort	G. N. Chistyakova
title	FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY
title_short	FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY
title_full	FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY
title_fullStr	FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY
title_full_unstemmed	FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY
title_sort	features of immune response in preterm babies with bronchopulmonary displasia of various severity
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/370d09e41d704fc8a10ab3e3fa31f2cd
work_keys_str_mv	AT gnchistyakova featuresofimmuneresponseinpretermbabieswithbronchopulmonarydisplasiaofvariousseverity AT iiremizova featuresofimmuneresponseinpretermbabieswithbronchopulmonarydisplasiaofvariousseverity AT lsustyantseva featuresofimmuneresponseinpretermbabieswithbronchopulmonarydisplasiaofvariousseverity AT kpshamova featuresofimmuneresponseinpretermbabieswithbronchopulmonarydisplasiaofvariousseverity AT svbychkova featuresofimmuneresponseinpretermbabieswithbronchopulmonarydisplasiaofvariousseverity AT mabotskovskaya featuresofimmuneresponseinpretermbabieswithbronchopulmonarydisplasiaofvariousseverity AT iagazieva featuresofimmuneresponseinpretermbabieswithbronchopulmonarydisplasiaofvariousseverity
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FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY

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