Human APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural infection.

Human APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural infection.

Human APOBEC3 proteins are cytidine deaminases that contribute broadly to innate immunity through the control of exogenous retrovirus replication and endogenous retroelement retrotransposition. As an intrinsic antiretroviral defense mechanism, APOBEC3 proteins induce extensive guanosine-to-adenosine...

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Bibliographic Details
Main Authors: Eun-Young Kim, Ramon Lorenzo-Redondo, Susan J Little, Yoon-Seok Chung, Prabhjeet K Phalora, Irina Maljkovic Berry, John Archer, Sudhir Penugonda, Will Fischer, Douglas D Richman, Tanmoy Bhattacharya, Michael H Malim, Steven M Wolinsky
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/370d1a339d744cdda8e3f55d1c1c4c79
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