Manganese systemic distribution is modulated in vivo during tumor progression and affects tumor cell migration and invasion in vitro

Abstract Metastatic disease remains the leading cause of death in cancer and understanding the mechanisms involved in tumor progression continues to be challenging. This work investigates the role of manganese in tumor progression in an in vivo model of tumor growth. Our data revealed that manganese...

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Autores principales:	Mariana Paranhos Stelling, Mariana Alves Soares, Simone Coutinho Cardoso, Juliana Maria Motta, Joice Côrtes de Abreu, Maria Júlia Mansur Antunes, Vitória Gonçalves de Freitas, João Alfredo Moraes, Morgana Teixeira Lima Castelo-Branco, Carlos Alberto Pérez, Mauro Sérgio Gonçalves Pavão
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/370f2dfe185d4939bf84bb7c3bcef871
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spelling	oai:doaj.org-article:370f2dfe185d4939bf84bb7c3bcef8712021-12-02T14:53:48ZManganese systemic distribution is modulated in vivo during tumor progression and affects tumor cell migration and invasion in vitro10.1038/s41598-021-95190-52045-2322https://doaj.org/article/370f2dfe185d4939bf84bb7c3bcef8712021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95190-5https://doaj.org/toc/2045-2322Abstract Metastatic disease remains the leading cause of death in cancer and understanding the mechanisms involved in tumor progression continues to be challenging. This work investigates the role of manganese in tumor progression in an in vivo model of tumor growth. Our data revealed that manganese accumulates within primary tumors and secondary organs as manganese-rich niches. Consequences of such phenomenon were investigated, and we verified that short-term changes in manganese alter cell surface molecules syndecan-1 and β1-integrin, enhance collective cell migration and invasive behavior. Long-term increased levels of manganese do not affect cell growth and viability but enhance cell migration. We also observed that manganese is secreted from tumor cells in extracellular vesicles, rather than in soluble form. Finally, we describe exogenous glycosaminoglycans that counteract manganese effects on tumor cell behavior. In conclusion, our analyses describe manganese as a central element in tumor progression by accumulating in Mn-rich niches in vivo, as well as in vitro, affecting migration and extracellular vesicle secretion in vitro. Manganese accumulation in specific regions of the organism may not be a common ground for all cancers, nevertheless, it represents a new aspect of tumor progression that deserves special attention.Mariana Paranhos StellingMariana Alves SoaresSimone Coutinho CardosoJuliana Maria MottaJoice Côrtes de AbreuMaria Júlia Mansur AntunesVitória Gonçalves de FreitasJoão Alfredo MoraesMorgana Teixeira Lima Castelo-BrancoCarlos Alberto PérezMauro Sérgio Gonçalves PavãoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mariana Paranhos Stelling Mariana Alves Soares Simone Coutinho Cardoso Juliana Maria Motta Joice Côrtes de Abreu Maria Júlia Mansur Antunes Vitória Gonçalves de Freitas João Alfredo Moraes Morgana Teixeira Lima Castelo-Branco Carlos Alberto Pérez Mauro Sérgio Gonçalves Pavão Manganese systemic distribution is modulated in vivo during tumor progression and affects tumor cell migration and invasion in vitro
description	Abstract Metastatic disease remains the leading cause of death in cancer and understanding the mechanisms involved in tumor progression continues to be challenging. This work investigates the role of manganese in tumor progression in an in vivo model of tumor growth. Our data revealed that manganese accumulates within primary tumors and secondary organs as manganese-rich niches. Consequences of such phenomenon were investigated, and we verified that short-term changes in manganese alter cell surface molecules syndecan-1 and β1-integrin, enhance collective cell migration and invasive behavior. Long-term increased levels of manganese do not affect cell growth and viability but enhance cell migration. We also observed that manganese is secreted from tumor cells in extracellular vesicles, rather than in soluble form. Finally, we describe exogenous glycosaminoglycans that counteract manganese effects on tumor cell behavior. In conclusion, our analyses describe manganese as a central element in tumor progression by accumulating in Mn-rich niches in vivo, as well as in vitro, affecting migration and extracellular vesicle secretion in vitro. Manganese accumulation in specific regions of the organism may not be a common ground for all cancers, nevertheless, it represents a new aspect of tumor progression that deserves special attention.
format	article
author	Mariana Paranhos Stelling Mariana Alves Soares Simone Coutinho Cardoso Juliana Maria Motta Joice Côrtes de Abreu Maria Júlia Mansur Antunes Vitória Gonçalves de Freitas João Alfredo Moraes Morgana Teixeira Lima Castelo-Branco Carlos Alberto Pérez Mauro Sérgio Gonçalves Pavão
author_facet	Mariana Paranhos Stelling Mariana Alves Soares Simone Coutinho Cardoso Juliana Maria Motta Joice Côrtes de Abreu Maria Júlia Mansur Antunes Vitória Gonçalves de Freitas João Alfredo Moraes Morgana Teixeira Lima Castelo-Branco Carlos Alberto Pérez Mauro Sérgio Gonçalves Pavão
author_sort	Mariana Paranhos Stelling
title	Manganese systemic distribution is modulated in vivo during tumor progression and affects tumor cell migration and invasion in vitro
title_short	Manganese systemic distribution is modulated in vivo during tumor progression and affects tumor cell migration and invasion in vitro
title_full	Manganese systemic distribution is modulated in vivo during tumor progression and affects tumor cell migration and invasion in vitro
title_fullStr	Manganese systemic distribution is modulated in vivo during tumor progression and affects tumor cell migration and invasion in vitro
title_full_unstemmed	Manganese systemic distribution is modulated in vivo during tumor progression and affects tumor cell migration and invasion in vitro
title_sort	manganese systemic distribution is modulated in vivo during tumor progression and affects tumor cell migration and invasion in vitro
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/370f2dfe185d4939bf84bb7c3bcef871
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Manganese systemic distribution is modulated in vivo during tumor progression and affects tumor cell migration and invasion in vitro

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