Acute and sub-chronic toxicological evaluation of the herbal product HAD-B1 in Beagle dogs

HAD-B1 is a herbal formula originated from Korean Traditional Medicine that used to treat lung cancer patients. Herein we assessed acute and sub-chronic toxicity of HAD-B1 in beagle dogs. Acute study, 4 weeks dose rate finding (DRF) study and sub chronic toxicity study for 13 weeks were done by oral...

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Autores principales:	Si-Yeon Song, Hyeok-Joon Chang, Soo-Dam Kim, Eun-Bin Kwag, So-Jung Park, Hwa-Seung Yoo
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Acute toxicity Sub-chronic study Lung cancer Korean traditional medicine Herbal product HAD-B1 Toxicology. Poisons RA1190-1270
Acceso en línea:	https://doaj.org/article/370f48f0f58b4bd6968b2d2324af10b5
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spelling	oai:doaj.org-article:370f48f0f58b4bd6968b2d2324af10b52021-11-10T04:27:36ZAcute and sub-chronic toxicological evaluation of the herbal product HAD-B1 in Beagle dogs2214-750010.1016/j.toxrep.2021.11.002https://doaj.org/article/370f48f0f58b4bd6968b2d2324af10b52021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2214750021001864https://doaj.org/toc/2214-7500HAD-B1 is a herbal formula originated from Korean Traditional Medicine that used to treat lung cancer patients. Herein we assessed acute and sub-chronic toxicity of HAD-B1 in beagle dogs. Acute study, 4 weeks dose rate finding (DRF) study and sub chronic toxicity study for 13 weeks were done by oral administration at doses of 0, 500, 1000, and 2000 mg/kg. Neither oral acute toxicity study nor DRF study showed any significant clinical signs, death, or weight changes. Based on that, a sub-chronic study for 13-weeks was performed. As a result, HAD-B1 caused a decrease of mean daily feed consumption in females, infiltration of intestinal inflammatory cells in both sexes, a significant decrease in total cholesterol (TCHO) in females, Kupffer cell hypertrophy/hyperplasia in the liver as well as dilation of the sinusoid. However, there were no significant toxic effects in the treated group compared to the control group. Therefore, the No Observed Adverse Effect Level (NOAEL) of the HAD-B1 is at least 2000 mg/kg/day when administrated orally for 13 consecutive weeks. These results demonstrate that HAD-B1 consumption is relatively non-toxic and safe for clinical usage.Si-Yeon SongHyeok-Joon ChangSoo-Dam KimEun-Bin KwagSo-Jung ParkHwa-Seung YooElsevierarticleAcute toxicitySub-chronic studyLung cancerKorean traditional medicineHerbal productHAD-B1Toxicology. PoisonsRA1190-1270ENToxicology Reports, Vol 8, Iss , Pp 1819-1829 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acute toxicity Sub-chronic study Lung cancer Korean traditional medicine Herbal product HAD-B1 Toxicology. Poisons RA1190-1270
spellingShingle	Acute toxicity Sub-chronic study Lung cancer Korean traditional medicine Herbal product HAD-B1 Toxicology. Poisons RA1190-1270 Si-Yeon Song Hyeok-Joon Chang Soo-Dam Kim Eun-Bin Kwag So-Jung Park Hwa-Seung Yoo Acute and sub-chronic toxicological evaluation of the herbal product HAD-B1 in Beagle dogs
description	HAD-B1 is a herbal formula originated from Korean Traditional Medicine that used to treat lung cancer patients. Herein we assessed acute and sub-chronic toxicity of HAD-B1 in beagle dogs. Acute study, 4 weeks dose rate finding (DRF) study and sub chronic toxicity study for 13 weeks were done by oral administration at doses of 0, 500, 1000, and 2000 mg/kg. Neither oral acute toxicity study nor DRF study showed any significant clinical signs, death, or weight changes. Based on that, a sub-chronic study for 13-weeks was performed. As a result, HAD-B1 caused a decrease of mean daily feed consumption in females, infiltration of intestinal inflammatory cells in both sexes, a significant decrease in total cholesterol (TCHO) in females, Kupffer cell hypertrophy/hyperplasia in the liver as well as dilation of the sinusoid. However, there were no significant toxic effects in the treated group compared to the control group. Therefore, the No Observed Adverse Effect Level (NOAEL) of the HAD-B1 is at least 2000 mg/kg/day when administrated orally for 13 consecutive weeks. These results demonstrate that HAD-B1 consumption is relatively non-toxic and safe for clinical usage.
format	article
author	Si-Yeon Song Hyeok-Joon Chang Soo-Dam Kim Eun-Bin Kwag So-Jung Park Hwa-Seung Yoo
author_facet	Si-Yeon Song Hyeok-Joon Chang Soo-Dam Kim Eun-Bin Kwag So-Jung Park Hwa-Seung Yoo
author_sort	Si-Yeon Song
title	Acute and sub-chronic toxicological evaluation of the herbal product HAD-B1 in Beagle dogs
title_short	Acute and sub-chronic toxicological evaluation of the herbal product HAD-B1 in Beagle dogs
title_full	Acute and sub-chronic toxicological evaluation of the herbal product HAD-B1 in Beagle dogs
title_fullStr	Acute and sub-chronic toxicological evaluation of the herbal product HAD-B1 in Beagle dogs
title_full_unstemmed	Acute and sub-chronic toxicological evaluation of the herbal product HAD-B1 in Beagle dogs
title_sort	acute and sub-chronic toxicological evaluation of the herbal product had-b1 in beagle dogs
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/370f48f0f58b4bd6968b2d2324af10b5
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Acute and sub-chronic toxicological evaluation of the herbal product HAD-B1 in Beagle dogs

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