Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting

Abstract Amongst other immune cells, neutrophils play a key role in systemic inflammation leading to cardiovascular disease and can release inflammatory factors, including lipocalin-2 (LCN2). LCN2 drives cardiac hypertrophy and plays a role in maladaptive remodelling of the heart and has been associ...

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Autores principales:	Michael E. Nakai, Joshua Denham, Priscilla R. Prestes, Nina Eikelis, Elisabeth A. Lambert, Nora E. Straznicky, Markus P. Schlaich, Murray D. Esler, Brendan J. O’Brien, Fadi J. Charchar, Gavin W. Lambert, Francine Z. Marques
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/371176a9aded4690970dc81a03253a7d
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spelling	oai:doaj.org-article:371176a9aded4690970dc81a03253a7d2021-12-02T12:11:45ZPlasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting10.1038/s41598-021-83472-x2045-2322https://doaj.org/article/371176a9aded4690970dc81a03253a7d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83472-xhttps://doaj.org/toc/2045-2322Abstract Amongst other immune cells, neutrophils play a key role in systemic inflammation leading to cardiovascular disease and can release inflammatory factors, including lipocalin-2 (LCN2). LCN2 drives cardiac hypertrophy and plays a role in maladaptive remodelling of the heart and has been associated with renal injury. While lifestyle factors such as diet and exercise are known to attenuate low-grade inflammation, their ability to modulate plasma LCN2 levels is unknown. Forty-eight endurance athletes and 52 controls (18–55 years) underwent measurement for various cardiovascular health indicators, along with plasma LCN2 concentration. No significant difference in LCN2 concentration was seen between the two groups. LCN2 was a very weak predictor or absent from models describing blood pressures or predicting athlete status. In another cohort, 57 non-diabetic overweight or obese men and post-menopausal women who fulfilled Adult Treatment Panel III metabolic syndrome criteria were randomly allocated into either a control, modified Dietary Approaches to Stop Hypertension (DASH) diet, or DASH and exercise group. Pre- and post-intervention demographic, cardiovascular health indicators, and plasma LCN2 expression were measured in each individual. While BMI fell in intervention groups, LCN2 levels remained unchanged within and between all groups, as illustrated by strong correlations between LCN2 concentrations pre- and 12 weeks post-intervention (r = 0.743, P < 0.0001). This suggests that circulating LCN2 expression are stable over a period of at least 12 weeks and is not modifiable by diet and exercise.Michael E. NakaiJoshua DenhamPriscilla R. PrestesNina EikelisElisabeth A. LambertNora E. StraznickyMarkus P. SchlaichMurray D. EslerBrendan J. O’BrienFadi J. CharcharGavin W. LambertFrancine Z. MarquesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael E. Nakai Joshua Denham Priscilla R. Prestes Nina Eikelis Elisabeth A. Lambert Nora E. Straznicky Markus P. Schlaich Murray D. Esler Brendan J. O’Brien Fadi J. Charchar Gavin W. Lambert Francine Z. Marques Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting
description	Abstract Amongst other immune cells, neutrophils play a key role in systemic inflammation leading to cardiovascular disease and can release inflammatory factors, including lipocalin-2 (LCN2). LCN2 drives cardiac hypertrophy and plays a role in maladaptive remodelling of the heart and has been associated with renal injury. While lifestyle factors such as diet and exercise are known to attenuate low-grade inflammation, their ability to modulate plasma LCN2 levels is unknown. Forty-eight endurance athletes and 52 controls (18–55 years) underwent measurement for various cardiovascular health indicators, along with plasma LCN2 concentration. No significant difference in LCN2 concentration was seen between the two groups. LCN2 was a very weak predictor or absent from models describing blood pressures or predicting athlete status. In another cohort, 57 non-diabetic overweight or obese men and post-menopausal women who fulfilled Adult Treatment Panel III metabolic syndrome criteria were randomly allocated into either a control, modified Dietary Approaches to Stop Hypertension (DASH) diet, or DASH and exercise group. Pre- and post-intervention demographic, cardiovascular health indicators, and plasma LCN2 expression were measured in each individual. While BMI fell in intervention groups, LCN2 levels remained unchanged within and between all groups, as illustrated by strong correlations between LCN2 concentrations pre- and 12 weeks post-intervention (r = 0.743, P < 0.0001). This suggests that circulating LCN2 expression are stable over a period of at least 12 weeks and is not modifiable by diet and exercise.
format	article
author	Michael E. Nakai Joshua Denham Priscilla R. Prestes Nina Eikelis Elisabeth A. Lambert Nora E. Straznicky Markus P. Schlaich Murray D. Esler Brendan J. O’Brien Fadi J. Charchar Gavin W. Lambert Francine Z. Marques
author_facet	Michael E. Nakai Joshua Denham Priscilla R. Prestes Nina Eikelis Elisabeth A. Lambert Nora E. Straznicky Markus P. Schlaich Murray D. Esler Brendan J. O’Brien Fadi J. Charchar Gavin W. Lambert Francine Z. Marques
author_sort	Michael E. Nakai
title	Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting
title_short	Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting
title_full	Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting
title_fullStr	Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting
title_full_unstemmed	Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting
title_sort	plasma lipocalin-2/ngal is stable over 12 weeks and is not modulated by exercise or dieting
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/371176a9aded4690970dc81a03253a7d
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Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting

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