Independent control of mean and noise by convolution of gene expression distributions

Gene expression noise can reduce fitness but analysis is hampered by a scaling relationship between noise and expression level. Here the authors show that gene expression mean and noise can be independently controlled by expressing two copies of a gene from separate inducible promoters in the same c...

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Autores principales:	Karl P. Gerhardt, Satyajit D. Rao, Evan J. Olson, Oleg A. Igoshin, Jeffrey J. Tabor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/37132251cd3a4015b9689403fd278277
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spelling	oai:doaj.org-article:37132251cd3a4015b9689403fd2782772021-12-05T12:23:08ZIndependent control of mean and noise by convolution of gene expression distributions10.1038/s41467-021-27070-52041-1723https://doaj.org/article/37132251cd3a4015b9689403fd2782772021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27070-5https://doaj.org/toc/2041-1723Gene expression noise can reduce fitness but analysis is hampered by a scaling relationship between noise and expression level. Here the authors show that gene expression mean and noise can be independently controlled by expressing two copies of a gene from separate inducible promoters in the same cell.Karl P. GerhardtSatyajit D. RaoEvan J. OlsonOleg A. IgoshinJeffrey J. TaborNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karl P. Gerhardt Satyajit D. Rao Evan J. Olson Oleg A. Igoshin Jeffrey J. Tabor Independent control of mean and noise by convolution of gene expression distributions
description	Gene expression noise can reduce fitness but analysis is hampered by a scaling relationship between noise and expression level. Here the authors show that gene expression mean and noise can be independently controlled by expressing two copies of a gene from separate inducible promoters in the same cell.
format	article
author	Karl P. Gerhardt Satyajit D. Rao Evan J. Olson Oleg A. Igoshin Jeffrey J. Tabor
author_facet	Karl P. Gerhardt Satyajit D. Rao Evan J. Olson Oleg A. Igoshin Jeffrey J. Tabor
author_sort	Karl P. Gerhardt
title	Independent control of mean and noise by convolution of gene expression distributions
title_short	Independent control of mean and noise by convolution of gene expression distributions
title_full	Independent control of mean and noise by convolution of gene expression distributions
title_fullStr	Independent control of mean and noise by convolution of gene expression distributions
title_full_unstemmed	Independent control of mean and noise by convolution of gene expression distributions
title_sort	independent control of mean and noise by convolution of gene expression distributions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/37132251cd3a4015b9689403fd278277
work_keys_str_mv	AT karlpgerhardt independentcontrolofmeanandnoisebyconvolutionofgeneexpressiondistributions AT satyajitdrao independentcontrolofmeanandnoisebyconvolutionofgeneexpressiondistributions AT evanjolson independentcontrolofmeanandnoisebyconvolutionofgeneexpressiondistributions AT olegaigoshin independentcontrolofmeanandnoisebyconvolutionofgeneexpressiondistributions AT jeffreyjtabor independentcontrolofmeanandnoisebyconvolutionofgeneexpressiondistributions
_version_	1718371951494299648

Independent control of mean and noise by convolution of gene expression distributions

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