Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width

Methionine availability is known to affect the global levels of histone methylation. Here the authors investigate the metabolically driven dynamics of H3K4me3 and find that methionine availability influences peak width, which is linked to changes in expression of genes associated with cell fate and...

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Autores principales:	Ziwei Dai, Samantha J. Mentch, Xia Gao, Sailendra N. Nichenametla, Jason W. Locasale
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3713a74cedbd488f8170cdb32441a952
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spelling	oai:doaj.org-article:3713a74cedbd488f8170cdb32441a9522021-12-02T15:34:28ZMethionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width10.1038/s41467-018-04426-y2041-1723https://doaj.org/article/3713a74cedbd488f8170cdb32441a9522018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04426-yhttps://doaj.org/toc/2041-1723Methionine availability is known to affect the global levels of histone methylation. Here the authors investigate the metabolically driven dynamics of H3K4me3 and find that methionine availability influences peak width, which is linked to changes in expression of genes associated with cell fate and cancer.Ziwei DaiSamantha J. MentchXia GaoSailendra N. NichenametlaJason W. LocasaleNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ziwei Dai Samantha J. Mentch Xia Gao Sailendra N. Nichenametla Jason W. Locasale Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width
description	Methionine availability is known to affect the global levels of histone methylation. Here the authors investigate the metabolically driven dynamics of H3K4me3 and find that methionine availability influences peak width, which is linked to changes in expression of genes associated with cell fate and cancer.
format	article
author	Ziwei Dai Samantha J. Mentch Xia Gao Sailendra N. Nichenametla Jason W. Locasale
author_facet	Ziwei Dai Samantha J. Mentch Xia Gao Sailendra N. Nichenametla Jason W. Locasale
author_sort	Ziwei Dai
title	Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width
title_short	Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width
title_full	Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width
title_fullStr	Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width
title_full_unstemmed	Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width
title_sort	methionine metabolism influences genomic architecture and gene expression through h3k4me3 peak width
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3713a74cedbd488f8170cdb32441a952
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_version_	1718386831804858368

Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width

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