In Vitro and In Vivo Photoprotective Effects of (-)-Loliode Isolated from the Brown Seaweed, <i>Sargassum horneri</i>

In Vitro and In Vivo Photoprotective Effects of (-)-Loliode Isolated from the Brown Seaweed, <i>Sargassum horneri</i>

Skin is the largest organ of humans. Overexposure to ultraviolet (UV) is the primary environmental factor that causes skin damage. The compound, (-)-loliode, isolated from the brown seaweed <i>Sargassum horneri</i>, showed strong antioxidant and anti-inflammatory activities in in vitro a...

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Autores principales: Lei Wang, Hyun-Soo Kim, Jun-Geon Je, Xiaoting Fu, Caoxing Huang, Ginnae Ahn, Jae-Young Oh, K. K. Asanka Sanjeewa, Jiachao Xu, Xin Gao, In-Kyu Yeo, You-Jin Jeon
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
<i>Sargassum horneri</i>
(-)-Loliode
UVB irradiation
ROS
MMPs
Organic chemistry
QD241-441
Acceso en línea:https://doaj.org/article/37162663a3104b288879107b4d664388
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spelling oai:doaj.org-article:37162663a3104b288879107b4d6643882021-11-25T18:28:13ZIn Vitro and In Vivo Photoprotective Effects of (-)-Loliode Isolated from the Brown Seaweed, <i>Sargassum horneri</i>10.3390/molecules262268981420-3049https://doaj.org/article/37162663a3104b288879107b4d6643882021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6898https://doaj.org/toc/1420-3049Skin is the largest organ of humans. Overexposure to ultraviolet (UV) is the primary environmental factor that causes skin damage. The compound, (-)-loliode, isolated from the brown seaweed <i>Sargassum horneri</i>, showed strong antioxidant and anti-inflammatory activities in in vitro and in vivo models. To further explore the potential of (-)-loliode in cosmetics, in the present study, we investigated the photoprotective effect of (-)-loliode in vitro in skin cells and in vivo in zebrafish. The results indicated that (-)-loliode significantly reduced intracellular reactive oxygen species (ROS) level, improved cell viability, and suppressed apoptosis of UVB-irradiated human keratinocytes. In addition, (-)-loliode remarkably attenuated oxidative damage, improved collagen synthesis, and inhibited matrix metalloproteinases expression in UVB-irradiated human dermal fibroblasts. Furthermore, the in vivo test demonstrated that (-)-loliode effectively and dose-dependently suppressed UVB-induced zebrafish damage displayed in decreasing the levels of ROS, nitric oxide, lipid peroxidation, and cell death in UVB-irradiated zebrafish. These results indicate that (-)-loliode possesses strong photoprotective activities and suggest (-)-loliode may an ideal ingredient in the pharmaceutical and cosmeceutical industries.Lei WangHyun-Soo KimJun-Geon JeXiaoting FuCaoxing HuangGinnae AhnJae-Young OhK. K. Asanka SanjeewaJiachao XuXin GaoIn-Kyu YeoYou-Jin JeonMDPI AGarticle<i>Sargassum horneri</i>(-)-LoliodeUVB irradiationROSMMPsOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6898, p 6898 (2021)
institution DOAJ
collection DOAJ
language EN
topic <i>Sargassum horneri</i>
(-)-Loliode
UVB irradiation
ROS
MMPs
Organic chemistry
QD241-441
spellingShingle <i>Sargassum horneri</i>
(-)-Loliode
UVB irradiation
ROS
MMPs
Organic chemistry
QD241-441
Lei Wang
Hyun-Soo Kim
Jun-Geon Je
Xiaoting Fu
Caoxing Huang
Ginnae Ahn
Jae-Young Oh
K. K. Asanka Sanjeewa
Jiachao Xu
Xin Gao
In-Kyu Yeo
You-Jin Jeon
In Vitro and In Vivo Photoprotective Effects of (-)-Loliode Isolated from the Brown Seaweed, <i>Sargassum horneri</i>
description Skin is the largest organ of humans. Overexposure to ultraviolet (UV) is the primary environmental factor that causes skin damage. The compound, (-)-loliode, isolated from the brown seaweed <i>Sargassum horneri</i>, showed strong antioxidant and anti-inflammatory activities in in vitro and in vivo models. To further explore the potential of (-)-loliode in cosmetics, in the present study, we investigated the photoprotective effect of (-)-loliode in vitro in skin cells and in vivo in zebrafish. The results indicated that (-)-loliode significantly reduced intracellular reactive oxygen species (ROS) level, improved cell viability, and suppressed apoptosis of UVB-irradiated human keratinocytes. In addition, (-)-loliode remarkably attenuated oxidative damage, improved collagen synthesis, and inhibited matrix metalloproteinases expression in UVB-irradiated human dermal fibroblasts. Furthermore, the in vivo test demonstrated that (-)-loliode effectively and dose-dependently suppressed UVB-induced zebrafish damage displayed in decreasing the levels of ROS, nitric oxide, lipid peroxidation, and cell death in UVB-irradiated zebrafish. These results indicate that (-)-loliode possesses strong photoprotective activities and suggest (-)-loliode may an ideal ingredient in the pharmaceutical and cosmeceutical industries.
format article
author Lei Wang
Hyun-Soo Kim
Jun-Geon Je
Xiaoting Fu
Caoxing Huang
Ginnae Ahn
Jae-Young Oh
K. K. Asanka Sanjeewa
Jiachao Xu
Xin Gao
In-Kyu Yeo
You-Jin Jeon
author_facet Lei Wang
Hyun-Soo Kim
Jun-Geon Je
Xiaoting Fu
Caoxing Huang
Ginnae Ahn
Jae-Young Oh
K. K. Asanka Sanjeewa
Jiachao Xu
Xin Gao
In-Kyu Yeo
You-Jin Jeon
author_sort Lei Wang
title In Vitro and In Vivo Photoprotective Effects of (-)-Loliode Isolated from the Brown Seaweed, <i>Sargassum horneri</i>
title_short In Vitro and In Vivo Photoprotective Effects of (-)-Loliode Isolated from the Brown Seaweed, <i>Sargassum horneri</i>
title_full In Vitro and In Vivo Photoprotective Effects of (-)-Loliode Isolated from the Brown Seaweed, <i>Sargassum horneri</i>
title_fullStr In Vitro and In Vivo Photoprotective Effects of (-)-Loliode Isolated from the Brown Seaweed, <i>Sargassum horneri</i>
title_full_unstemmed In Vitro and In Vivo Photoprotective Effects of (-)-Loliode Isolated from the Brown Seaweed, <i>Sargassum horneri</i>
title_sort in vitro and in vivo photoprotective effects of (-)-loliode isolated from the brown seaweed, <i>sargassum horneri</i>
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/37162663a3104b288879107b4d664388
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