A single amino acid substitution confers B-cell clonogenic activity to the HIV-1 matrix protein p17

A single amino acid substitution confers B-cell clonogenic activity to the HIV-1 matrix protein p17

Abstract Recent data highlight the presence, in HIV-1-seropositive patients with lymphoma, of p17 variants (vp17s) endowed with B-cell clonogenicity, suggesting a role of vp17s in lymphomagenesis. We investigated the mechanisms responsible for the functional disparity on B cells between a wild-type...

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Main Authors: Cinzia Giagulli, Pasqualina D’Ursi, Wangxiao He, Simone Zorzan, Francesca Caccuri, Kristen Varney, Alessandro Orro, Stefania Marsico, Benoît Otjacques, Carlo Laudanna, Luciano Milanesi, Riccardo Dolcetti, Simona Fiorentini, Wuyuan Lu, Arnaldo Caruso
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/37164eca0acc4c81856e41043502f4a4
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https://doaj.org/article/37164eca0acc4c81856e41043502f4a4

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