Identification and Preliminary Structure-Activity Relationship Studies of 1,5-Dihydrobenzo[<i>e</i>][1,4]oxazepin-2(3<i>H</i>)-ones That Induce Differentiation of Acute Myeloid Leukemia Cells In Vitro

Identification and Preliminary Structure-Activity Relationship Studies of 1,5-Dihydrobenzo[<i>e</i>][1,4]oxazepin-2(3<i>H</i>)-ones That Induce Differentiation of Acute Myeloid Leukemia Cells In Vitro

Acute myeloid leukemia (AML) is the most aggressive type of blood cancer, and there is a continued need for new treatments that are well tolerated and improve long-term survival rates in patients. Induction of differentiation has emerged as a promising alternative to conventional cytotoxic chemother...

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Autores principales: Laia Josa-Culleré, Thomas J. Cogswell, Irene Georgiou, Morgan Jay-Smith, Thomas R. Jackson, Carole J. R. Bataille, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
acute myeloid leukemia
differentiation
phenotypic screen
CD11b
benzooxazepinones
Organic chemistry
QD241-441
Acceso en línea:https://doaj.org/article/371c3b38b9e44be49d8dc114324e28ce
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