Influence of Atomoxetine on Relationship Between ADHD Symptoms and Prefrontal Cortex Activity During Task Execution in Adult Patients
Objective: We conducted this non-randomized prospective interventional study to clarify the relationship between improved attention-deficit hyperactivity disorder (ADHD) symptoms and regional brain activity.Methods: Thirty-one adult patients underwent near-infrared spectroscopy examinations during a...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:371d362acba3401593e5d32741384f882021-12-01T09:03:48ZInfluence of Atomoxetine on Relationship Between ADHD Symptoms and Prefrontal Cortex Activity During Task Execution in Adult Patients1662-516110.3389/fnhum.2021.755025https://doaj.org/article/371d362acba3401593e5d32741384f882021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnhum.2021.755025/fullhttps://doaj.org/toc/1662-5161Objective: We conducted this non-randomized prospective interventional study to clarify the relationship between improved attention-deficit hyperactivity disorder (ADHD) symptoms and regional brain activity.Methods: Thirty-one adult patients underwent near-infrared spectroscopy examinations during a go/no-go task, both before and 8 weeks after atomoxetine administration.Results: Clinical symptoms, neuropsychological results of the go/no-go task, and bilateral lateral prefrontal activity significantly changed. A positive correlation was observed between right dorsolateral prefrontal cortex activity and Conners’ Adult ADHD Rating Scales scores. Before atomoxetine administration, no correlations between prefrontal cortex activity and clinical symptoms were observed in all cases. When participants were divided into atomoxetine-responder and non-responder groups, a positive correlation was observed between prefrontal cortex activity and clinical symptoms in the non-responder group before treatment but not in the responder group, suggesting that non-responders can activate the prefrontal cortex without atomoxetine.Conclusions: Individuals with increased ADHD symptoms appear to recruit the right dorsolateral prefrontal cortex more strongly to perform the same task than those with fewer symptoms. In clinical settings, individuals with severe symptoms are often observed to perform more difficultly when performing the tasks which individuals with mild symptoms can perform easily. The atomoxetine-responder group was unable to properly activate the right dorsolateral prefrontal cortex when necessary, and the oral administration of atomoxetine enabled these patients to activate this region. In brain imaging studies of heterogeneous syndromes such as ADHD, the analytical strategy used in this study, involving drug-responsivity grouping, may effectively increase the signal-to-noise ratio.Atsunori SugimotoAtsunori SugimotoYutaro SuzukiYutaro SuzukiKiyohiro YoshinagaKiyohiro YoshinagaNaoki OrimeTaketsugu HayashiTaketsugu HayashiJun EgawaShin OnoShin OnoTakuro SugaiToshiyuki SomeyaFrontiers Media S.A.articleatomoxetineattention-deficit/hyperactivity disorderConners’ adult ADHD rating scalesgo/no-go tasknear-infrared spectroscopyresponder groupNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Human Neuroscience, Vol 15 (2021) |
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| collection |
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EN |
| topic |
atomoxetine attention-deficit/hyperactivity disorder Conners’ adult ADHD rating scales go/no-go task near-infrared spectroscopy responder group Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
| spellingShingle |
atomoxetine attention-deficit/hyperactivity disorder Conners’ adult ADHD rating scales go/no-go task near-infrared spectroscopy responder group Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Atsunori Sugimoto Atsunori Sugimoto Yutaro Suzuki Yutaro Suzuki Kiyohiro Yoshinaga Kiyohiro Yoshinaga Naoki Orime Taketsugu Hayashi Taketsugu Hayashi Jun Egawa Shin Ono Shin Ono Takuro Sugai Toshiyuki Someya Influence of Atomoxetine on Relationship Between ADHD Symptoms and Prefrontal Cortex Activity During Task Execution in Adult Patients |
| description |
Objective: We conducted this non-randomized prospective interventional study to clarify the relationship between improved attention-deficit hyperactivity disorder (ADHD) symptoms and regional brain activity.Methods: Thirty-one adult patients underwent near-infrared spectroscopy examinations during a go/no-go task, both before and 8 weeks after atomoxetine administration.Results: Clinical symptoms, neuropsychological results of the go/no-go task, and bilateral lateral prefrontal activity significantly changed. A positive correlation was observed between right dorsolateral prefrontal cortex activity and Conners’ Adult ADHD Rating Scales scores. Before atomoxetine administration, no correlations between prefrontal cortex activity and clinical symptoms were observed in all cases. When participants were divided into atomoxetine-responder and non-responder groups, a positive correlation was observed between prefrontal cortex activity and clinical symptoms in the non-responder group before treatment but not in the responder group, suggesting that non-responders can activate the prefrontal cortex without atomoxetine.Conclusions: Individuals with increased ADHD symptoms appear to recruit the right dorsolateral prefrontal cortex more strongly to perform the same task than those with fewer symptoms. In clinical settings, individuals with severe symptoms are often observed to perform more difficultly when performing the tasks which individuals with mild symptoms can perform easily. The atomoxetine-responder group was unable to properly activate the right dorsolateral prefrontal cortex when necessary, and the oral administration of atomoxetine enabled these patients to activate this region. In brain imaging studies of heterogeneous syndromes such as ADHD, the analytical strategy used in this study, involving drug-responsivity grouping, may effectively increase the signal-to-noise ratio. |
| format |
article |
| author |
Atsunori Sugimoto Atsunori Sugimoto Yutaro Suzuki Yutaro Suzuki Kiyohiro Yoshinaga Kiyohiro Yoshinaga Naoki Orime Taketsugu Hayashi Taketsugu Hayashi Jun Egawa Shin Ono Shin Ono Takuro Sugai Toshiyuki Someya |
| author_facet |
Atsunori Sugimoto Atsunori Sugimoto Yutaro Suzuki Yutaro Suzuki Kiyohiro Yoshinaga Kiyohiro Yoshinaga Naoki Orime Taketsugu Hayashi Taketsugu Hayashi Jun Egawa Shin Ono Shin Ono Takuro Sugai Toshiyuki Someya |
| author_sort |
Atsunori Sugimoto |
| title |
Influence of Atomoxetine on Relationship Between ADHD Symptoms and Prefrontal Cortex Activity During Task Execution in Adult Patients |
| title_short |
Influence of Atomoxetine on Relationship Between ADHD Symptoms and Prefrontal Cortex Activity During Task Execution in Adult Patients |
| title_full |
Influence of Atomoxetine on Relationship Between ADHD Symptoms and Prefrontal Cortex Activity During Task Execution in Adult Patients |
| title_fullStr |
Influence of Atomoxetine on Relationship Between ADHD Symptoms and Prefrontal Cortex Activity During Task Execution in Adult Patients |
| title_full_unstemmed |
Influence of Atomoxetine on Relationship Between ADHD Symptoms and Prefrontal Cortex Activity During Task Execution in Adult Patients |
| title_sort |
influence of atomoxetine on relationship between adhd symptoms and prefrontal cortex activity during task execution in adult patients |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/371d362acba3401593e5d32741384f88 |
| work_keys_str_mv |
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| _version_ |
1718405348377755648 |