Environmental chemicals in dog testes reflect their geographical source and may be associated with altered pathology

Abstract In humans and dogs, a temporal decline in semen quality and increased incidence of testicular cancer is hypothesised to be associated with exposure to anthropogenic chemicals, particularly during fetal development. Human studies suggest that differential exposures to environmental chemicals...

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Autores principales:	Rebecca N. Sumner, Andrew Byers, Zulin Zhang, Jorgen S. Agerholm, Lena Lindh, Gary C. W. England, Richard G. Lea
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3720a65c41e54216b4c97e9f9189fdc8
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spelling	oai:doaj.org-article:3720a65c41e54216b4c97e9f9189fdc82021-12-02T14:25:09ZEnvironmental chemicals in dog testes reflect their geographical source and may be associated with altered pathology10.1038/s41598-021-86805-y2045-2322https://doaj.org/article/3720a65c41e54216b4c97e9f9189fdc82021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86805-yhttps://doaj.org/toc/2045-2322Abstract In humans and dogs, a temporal decline in semen quality and increased incidence of testicular cancer is hypothesised to be associated with exposure to anthropogenic chemicals, particularly during fetal development. Human studies suggest that differential exposures to environmental chemicals may be associated with geographical differences in male reproductive health. Here we investigate testicular chemical profiles and pathologies in dogs residing in the UK [West Midlands (WM), East Midlands (EM), South East (SE)], Denmark (Copenhagen) and Finland (Vantaa). Testes, surplus from routine castrations, contained region specific differences in relative concentrations of diethylhexyl phthalate (DEHP), polybrominated diphenyl ethers (PBDE) and polychlorinated biphenyls (PCB). Relative to UK regions, testes from dogs living in Finland and Denmark had higher concentrations of PBDE and lower concentrations of DEHP and PCBs. Regional differences in the UK in PCB concentrations were also observed. Dog testes from Finland had fewer pathologies, reduced testicular area stained for Sertoli and germ cells and evidence of reduced cellular proliferation. Since the geographical differences in testis pathologies in dogs parallel reports of regional differences in human testicular cancer, we postulate that this may reflect chemical effects within the testis and that this may be related to environmental influences on male reproductive function.Rebecca N. SumnerAndrew ByersZulin ZhangJorgen S. AgerholmLena LindhGary C. W. EnglandRichard G. LeaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rebecca N. Sumner Andrew Byers Zulin Zhang Jorgen S. Agerholm Lena Lindh Gary C. W. England Richard G. Lea Environmental chemicals in dog testes reflect their geographical source and may be associated with altered pathology
description	Abstract In humans and dogs, a temporal decline in semen quality and increased incidence of testicular cancer is hypothesised to be associated with exposure to anthropogenic chemicals, particularly during fetal development. Human studies suggest that differential exposures to environmental chemicals may be associated with geographical differences in male reproductive health. Here we investigate testicular chemical profiles and pathologies in dogs residing in the UK [West Midlands (WM), East Midlands (EM), South East (SE)], Denmark (Copenhagen) and Finland (Vantaa). Testes, surplus from routine castrations, contained region specific differences in relative concentrations of diethylhexyl phthalate (DEHP), polybrominated diphenyl ethers (PBDE) and polychlorinated biphenyls (PCB). Relative to UK regions, testes from dogs living in Finland and Denmark had higher concentrations of PBDE and lower concentrations of DEHP and PCBs. Regional differences in the UK in PCB concentrations were also observed. Dog testes from Finland had fewer pathologies, reduced testicular area stained for Sertoli and germ cells and evidence of reduced cellular proliferation. Since the geographical differences in testis pathologies in dogs parallel reports of regional differences in human testicular cancer, we postulate that this may reflect chemical effects within the testis and that this may be related to environmental influences on male reproductive function.
format	article
author	Rebecca N. Sumner Andrew Byers Zulin Zhang Jorgen S. Agerholm Lena Lindh Gary C. W. England Richard G. Lea
author_facet	Rebecca N. Sumner Andrew Byers Zulin Zhang Jorgen S. Agerholm Lena Lindh Gary C. W. England Richard G. Lea
author_sort	Rebecca N. Sumner
title	Environmental chemicals in dog testes reflect their geographical source and may be associated with altered pathology
title_short	Environmental chemicals in dog testes reflect their geographical source and may be associated with altered pathology
title_full	Environmental chemicals in dog testes reflect their geographical source and may be associated with altered pathology
title_fullStr	Environmental chemicals in dog testes reflect their geographical source and may be associated with altered pathology
title_full_unstemmed	Environmental chemicals in dog testes reflect their geographical source and may be associated with altered pathology
title_sort	environmental chemicals in dog testes reflect their geographical source and may be associated with altered pathology
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3720a65c41e54216b4c97e9f9189fdc8
work_keys_str_mv	AT rebeccansumner environmentalchemicalsindogtestesreflecttheirgeographicalsourceandmaybeassociatedwithalteredpathology AT andrewbyers environmentalchemicalsindogtestesreflecttheirgeographicalsourceandmaybeassociatedwithalteredpathology AT zulinzhang environmentalchemicalsindogtestesreflecttheirgeographicalsourceandmaybeassociatedwithalteredpathology AT jorgensagerholm environmentalchemicalsindogtestesreflecttheirgeographicalsourceandmaybeassociatedwithalteredpathology AT lenalindh environmentalchemicalsindogtestesreflecttheirgeographicalsourceandmaybeassociatedwithalteredpathology AT garycwengland environmentalchemicalsindogtestesreflecttheirgeographicalsourceandmaybeassociatedwithalteredpathology AT richardglea environmentalchemicalsindogtestesreflecttheirgeographicalsourceandmaybeassociatedwithalteredpathology
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Environmental chemicals in dog testes reflect their geographical source and may be associated with altered pathology

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