A potentially abundant junctional RNA motif stabilized by m6A and Mg2+

N 6-Methyladenosine (m6A) is a post-transcriptional RNA modification that modulates RNA structure through a destabilization of m6A base pairing. Here the authors use NMR and UV melting experiments and show that m6A can also stabilize m6A–U base pairs and global RNA structure when positioned adjacent...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bei Liu, Dawn K. Merriman, Seung H. Choi, Maria A. Schumacher, Raphael Plangger, Christoph Kreutz, Stacy M. Horner, Kate D. Meyer, Hashim M. Al-Hashimi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/372622a59f9c424c8a4a6aac13ebbfc3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:372622a59f9c424c8a4a6aac13ebbfc3
record_format	dspace
spelling	oai:doaj.org-article:372622a59f9c424c8a4a6aac13ebbfc32021-12-02T15:34:26ZA potentially abundant junctional RNA motif stabilized by m6A and Mg2+10.1038/s41467-018-05243-z2041-1723https://doaj.org/article/372622a59f9c424c8a4a6aac13ebbfc32018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05243-zhttps://doaj.org/toc/2041-1723N 6-Methyladenosine (m6A) is a post-transcriptional RNA modification that modulates RNA structure through a destabilization of m6A base pairing. Here the authors use NMR and UV melting experiments and show that m6A can also stabilize m6A–U base pairs and global RNA structure when positioned adjacent to a 5ʹ bulge.Bei LiuDawn K. MerrimanSeung H. ChoiMaria A. SchumacherRaphael PlanggerChristoph KreutzStacy M. HornerKate D. MeyerHashim M. Al-HashimiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bei Liu Dawn K. Merriman Seung H. Choi Maria A. Schumacher Raphael Plangger Christoph Kreutz Stacy M. Horner Kate D. Meyer Hashim M. Al-Hashimi A potentially abundant junctional RNA motif stabilized by m6A and Mg2+
description	N 6-Methyladenosine (m6A) is a post-transcriptional RNA modification that modulates RNA structure through a destabilization of m6A base pairing. Here the authors use NMR and UV melting experiments and show that m6A can also stabilize m6A–U base pairs and global RNA structure when positioned adjacent to a 5ʹ bulge.
format	article
author	Bei Liu Dawn K. Merriman Seung H. Choi Maria A. Schumacher Raphael Plangger Christoph Kreutz Stacy M. Horner Kate D. Meyer Hashim M. Al-Hashimi
author_facet	Bei Liu Dawn K. Merriman Seung H. Choi Maria A. Schumacher Raphael Plangger Christoph Kreutz Stacy M. Horner Kate D. Meyer Hashim M. Al-Hashimi
author_sort	Bei Liu
title	A potentially abundant junctional RNA motif stabilized by m6A and Mg2+
title_short	A potentially abundant junctional RNA motif stabilized by m6A and Mg2+
title_full	A potentially abundant junctional RNA motif stabilized by m6A and Mg2+
title_fullStr	A potentially abundant junctional RNA motif stabilized by m6A and Mg2+
title_full_unstemmed	A potentially abundant junctional RNA motif stabilized by m6A and Mg2+
title_sort	potentially abundant junctional rna motif stabilized by m6a and mg2+
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/372622a59f9c424c8a4a6aac13ebbfc3
work_keys_str_mv	AT beiliu apotentiallyabundantjunctionalrnamotifstabilizedbym6aandmg2 AT dawnkmerriman apotentiallyabundantjunctionalrnamotifstabilizedbym6aandmg2 AT seunghchoi apotentiallyabundantjunctionalrnamotifstabilizedbym6aandmg2 AT mariaaschumacher apotentiallyabundantjunctionalrnamotifstabilizedbym6aandmg2 AT raphaelplangger apotentiallyabundantjunctionalrnamotifstabilizedbym6aandmg2 AT christophkreutz apotentiallyabundantjunctionalrnamotifstabilizedbym6aandmg2 AT stacymhorner apotentiallyabundantjunctionalrnamotifstabilizedbym6aandmg2 AT katedmeyer apotentiallyabundantjunctionalrnamotifstabilizedbym6aandmg2 AT hashimmalhashimi apotentiallyabundantjunctionalrnamotifstabilizedbym6aandmg2 AT beiliu potentiallyabundantjunctionalrnamotifstabilizedbym6aandmg2 AT dawnkmerriman potentiallyabundantjunctionalrnamotifstabilizedbym6aandmg2 AT seunghchoi potentiallyabundantjunctionalrnamotifstabilizedbym6aandmg2 AT mariaaschumacher potentiallyabundantjunctionalrnamotifstabilizedbym6aandmg2 AT raphaelplangger potentiallyabundantjunctionalrnamotifstabilizedbym6aandmg2 AT christophkreutz potentiallyabundantjunctionalrnamotifstabilizedbym6aandmg2 AT stacymhorner potentiallyabundantjunctionalrnamotifstabilizedbym6aandmg2 AT katedmeyer potentiallyabundantjunctionalrnamotifstabilizedbym6aandmg2 AT hashimmalhashimi potentiallyabundantjunctionalrnamotifstabilizedbym6aandmg2
_version_	1718386831998844928

A potentially abundant junctional RNA motif stabilized by m6A and Mg2+

Ejemplares similares