Altered dorsal functional connectivity after post-weaning social isolation and resocialization in mice

Background: Social isolation (SI) leads to various mental health disorders. Despite abundant studies on behavioral and neurobiological changes induced by post-weaning SI, the characterization of its imaging correlates, such as resting-state functional connectivity (RSFC), is critically lacking. In a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gaon Sandy Kim, Hyoin Lee, Yong Jeong
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Social isolation Wide-field optical imaging Resting-state functional connectivity Graph analysis Resocialization Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/3728a1e5c081447382ab51b8d4f7b625
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3728a1e5c081447382ab51b8d4f7b625
record_format	dspace
spelling	oai:doaj.org-article:3728a1e5c081447382ab51b8d4f7b6252021-11-28T04:29:11ZAltered dorsal functional connectivity after post-weaning social isolation and resocialization in mice1095-957210.1016/j.neuroimage.2021.118740https://doaj.org/article/3728a1e5c081447382ab51b8d4f7b6252021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1053811921010120https://doaj.org/toc/1095-9572Background: Social isolation (SI) leads to various mental health disorders. Despite abundant studies on behavioral and neurobiological changes induced by post-weaning SI, the characterization of its imaging correlates, such as resting-state functional connectivity (RSFC), is critically lacking. In addition, the effects of resocialization after isolation remain unclear. Therefore, this study aimed to explore the effects of 1) SI on cortical functional connectivity and 2) subsequent resocialization on behavior and functional connectivity. Methods: Behavioral tests were conducted to validate the post-weaning SI mouse model, which is isolated during the juvenile period. Wide-field optical mapping was performed to observe both neuronal and hemodynamic signals in the cortex under anesthesia. Using seed-based and graph theoretical analyses, RSFC was analyzed. SI mice were then resocialized and the array of behavior and imaging tests was conducted. Results: Behaviorally, SI mice showed elevated anxiety, social preference, and aggression. RSFC analyses using the seed-based approach revealed decreased cortical functional connectivity in SI mice, especially in the frontal region. Graph network analyses demonstrated significant reduction in network segregation measures. After resocialization, mice exhibited recovered anxiogenic and aggressive behavior, but RSFC data did not show significant changes. Conclusions: We observed an overall decrease in functional connectivity in SI mice. Moreover, resocialization restored the disruptions in behavioral patterns but functional connectivity was not recovered. To our knowledge, this is the first study to report that, despite the recovering tendencies of behavior in resocialized mice, similar changes in RSFC were not observed. This suggests that disruptions in functional connectivity caused by social isolation remain as long-term sequelae.Gaon Sandy KimHyoin LeeYong JeongElsevierarticleSocial isolationWide-field optical imagingResting-state functional connectivityGraph analysisResocializationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118740- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Social isolation Wide-field optical imaging Resting-state functional connectivity Graph analysis Resocialization Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Social isolation Wide-field optical imaging Resting-state functional connectivity Graph analysis Resocialization Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Gaon Sandy Kim Hyoin Lee Yong Jeong Altered dorsal functional connectivity after post-weaning social isolation and resocialization in mice
description	Background: Social isolation (SI) leads to various mental health disorders. Despite abundant studies on behavioral and neurobiological changes induced by post-weaning SI, the characterization of its imaging correlates, such as resting-state functional connectivity (RSFC), is critically lacking. In addition, the effects of resocialization after isolation remain unclear. Therefore, this study aimed to explore the effects of 1) SI on cortical functional connectivity and 2) subsequent resocialization on behavior and functional connectivity. Methods: Behavioral tests were conducted to validate the post-weaning SI mouse model, which is isolated during the juvenile period. Wide-field optical mapping was performed to observe both neuronal and hemodynamic signals in the cortex under anesthesia. Using seed-based and graph theoretical analyses, RSFC was analyzed. SI mice were then resocialized and the array of behavior and imaging tests was conducted. Results: Behaviorally, SI mice showed elevated anxiety, social preference, and aggression. RSFC analyses using the seed-based approach revealed decreased cortical functional connectivity in SI mice, especially in the frontal region. Graph network analyses demonstrated significant reduction in network segregation measures. After resocialization, mice exhibited recovered anxiogenic and aggressive behavior, but RSFC data did not show significant changes. Conclusions: We observed an overall decrease in functional connectivity in SI mice. Moreover, resocialization restored the disruptions in behavioral patterns but functional connectivity was not recovered. To our knowledge, this is the first study to report that, despite the recovering tendencies of behavior in resocialized mice, similar changes in RSFC were not observed. This suggests that disruptions in functional connectivity caused by social isolation remain as long-term sequelae.
format	article
author	Gaon Sandy Kim Hyoin Lee Yong Jeong
author_facet	Gaon Sandy Kim Hyoin Lee Yong Jeong
author_sort	Gaon Sandy Kim
title	Altered dorsal functional connectivity after post-weaning social isolation and resocialization in mice
title_short	Altered dorsal functional connectivity after post-weaning social isolation and resocialization in mice
title_full	Altered dorsal functional connectivity after post-weaning social isolation and resocialization in mice
title_fullStr	Altered dorsal functional connectivity after post-weaning social isolation and resocialization in mice
title_full_unstemmed	Altered dorsal functional connectivity after post-weaning social isolation and resocialization in mice
title_sort	altered dorsal functional connectivity after post-weaning social isolation and resocialization in mice
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/3728a1e5c081447382ab51b8d4f7b625
work_keys_str_mv	AT gaonsandykim altereddorsalfunctionalconnectivityafterpostweaningsocialisolationandresocializationinmice AT hyoinlee altereddorsalfunctionalconnectivityafterpostweaningsocialisolationandresocializationinmice AT yongjeong altereddorsalfunctionalconnectivityafterpostweaningsocialisolationandresocializationinmice
_version_	1718408371582795776

Altered dorsal functional connectivity after post-weaning social isolation and resocialization in mice

Ejemplares similares