Reproductive life events and Alzheimer’s disease in Italian women: a retrospective study

Reproductive life events and Alzheimer’s disease in Italian women: a retrospective study

Chiara Zucchella,1 Elena Sinforiani,1 Antonietta Citterio,1 Valentina Giarracca,2 Giorgio Bono,2 Marco Mauri21IRCCS National Neurological Institute, C Mondino Foundation, Pavia, Italy; 2Department of Neurology, Ospedale di Circolo/Università dell’Insubria, Varese, ItalyA...

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Autores principales: Bono G, Giarracca V, Citterio A, Sinforiani E, Zucchella C, Mauri M
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2012
Materias:
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/3729cc05b4a747beb9300c2a7826b0b4
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spelling oai:doaj.org-article:3729cc05b4a747beb9300c2a7826b0b42021-12-02T05:33:03ZReproductive life events and Alzheimer’s disease in Italian women: a retrospective study1176-63281178-2021https://doaj.org/article/3729cc05b4a747beb9300c2a7826b0b42012-11-01T00:00:00Zhttp://www.dovepress.com/reproductive-life-events-and-alzheimerrsquos-disease-in-italian-women--a11573https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Chiara Zucchella,1 Elena Sinforiani,1 Antonietta Citterio,1 Valentina Giarracca,2 Giorgio Bono,2 Marco Mauri21IRCCS National Neurological Institute, C Mondino Foundation, Pavia, Italy; 2Department of Neurology, Ospedale di Circolo/Università dell’Insubria, Varese, ItalyAbstract: The aim of our study was to understand the complex relationship between the major reproductive life events in women with Alzheimer’s disease. In a retrospective, case-control study, 275 women with Alzheimer’s disease (AD) and 276 control patients from a hospital population were enrolled from July 2007 to December 2010. The AD patients presented with later menopause (P < 0.01), lower occurrence of surgical menopause (P < 0.04), reduced hormone-replacement therapy intake (P < 0.0001), and a longer reproductive life span (P < 0.01), compared to controls. No significant differences were found with respect to age at puberty, number of pregnancies, previous abortions, or contraceptive therapy. A higher education level appeared to have a protective role against the risk of developing AD. In women, menopause and hormone-replacement therapy can differentially modulate the clinical manifestations of AD, but these factors do not play a predictive role in its development.Keywords: Alzheimer’s disease, gender, menopause, hormone-replacement therapy, surgical menopause, educationBono GGiarracca VCitterio ASinforiani EZucchella CMauri MDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2012, Iss default, Pp 555-560 (2012)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Bono G
Giarracca V
Citterio A
Sinforiani E
Zucchella C
Mauri M
Reproductive life events and Alzheimer’s disease in Italian women: a retrospective study
description Chiara Zucchella,1 Elena Sinforiani,1 Antonietta Citterio,1 Valentina Giarracca,2 Giorgio Bono,2 Marco Mauri21IRCCS National Neurological Institute, C Mondino Foundation, Pavia, Italy; 2Department of Neurology, Ospedale di Circolo/Università dell’Insubria, Varese, ItalyAbstract: The aim of our study was to understand the complex relationship between the major reproductive life events in women with Alzheimer’s disease. In a retrospective, case-control study, 275 women with Alzheimer’s disease (AD) and 276 control patients from a hospital population were enrolled from July 2007 to December 2010. The AD patients presented with later menopause (P < 0.01), lower occurrence of surgical menopause (P < 0.04), reduced hormone-replacement therapy intake (P < 0.0001), and a longer reproductive life span (P < 0.01), compared to controls. No significant differences were found with respect to age at puberty, number of pregnancies, previous abortions, or contraceptive therapy. A higher education level appeared to have a protective role against the risk of developing AD. In women, menopause and hormone-replacement therapy can differentially modulate the clinical manifestations of AD, but these factors do not play a predictive role in its development.Keywords: Alzheimer’s disease, gender, menopause, hormone-replacement therapy, surgical menopause, education
format article
author Bono G
Giarracca V
Citterio A
Sinforiani E
Zucchella C
Mauri M
author_facet Bono G
Giarracca V
Citterio A
Sinforiani E
Zucchella C
Mauri M
author_sort Bono G
title Reproductive life events and Alzheimer’s disease in Italian women: a retrospective study
title_short Reproductive life events and Alzheimer’s disease in Italian women: a retrospective study
title_full Reproductive life events and Alzheimer’s disease in Italian women: a retrospective study
title_fullStr Reproductive life events and Alzheimer’s disease in Italian women: a retrospective study
title_full_unstemmed Reproductive life events and Alzheimer’s disease in Italian women: a retrospective study
title_sort reproductive life events and alzheimer’s disease in italian women: a retrospective study
publisher Dove Medical Press
publishDate 2012
url https://doaj.org/article/3729cc05b4a747beb9300c2a7826b0b4
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AT giarraccav reproductivelifeeventsandalzheimeramprsquosdiseaseinitalianwomenaretrospectivestudy
AT citterioa reproductivelifeeventsandalzheimeramprsquosdiseaseinitalianwomenaretrospectivestudy
AT sinforianie reproductivelifeeventsandalzheimeramprsquosdiseaseinitalianwomenaretrospectivestudy
AT zucchellac reproductivelifeeventsandalzheimeramprsquosdiseaseinitalianwomenaretrospectivestudy
AT maurim reproductivelifeeventsandalzheimeramprsquosdiseaseinitalianwomenaretrospectivestudy
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