Clinical Analysis of Macular Choroidal Thickness in Pseudoexfoliative Glaucoma and Primary Open-Angle Glaucoma

Purpose. To evaluate the differences in macular choroidal thickness and volume among patients with pseudoexfoliative glaucoma (PXG), patients with primary open-angle glaucoma (POAG), and controls. Methods. A total of 50 PXG patients (50 eyes) and 56 POAG patients (56 eyes) were selected as the PXG g...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fan Li, Yiming Huo, Lihua Ma, Qing Zhang, Hengli Zhang, Xiaowei Yan, Yulei Geng, Guangxian Tang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/372ab2e246d048cfb65ef84101bbf421
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:372ab2e246d048cfb65ef84101bbf421
record_format	dspace
spelling	oai:doaj.org-article:372ab2e246d048cfb65ef84101bbf4212021-11-29T00:55:26ZClinical Analysis of Macular Choroidal Thickness in Pseudoexfoliative Glaucoma and Primary Open-Angle Glaucoma2090-005810.1155/2021/3897952https://doaj.org/article/372ab2e246d048cfb65ef84101bbf4212021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/3897952https://doaj.org/toc/2090-0058Purpose. To evaluate the differences in macular choroidal thickness and volume among patients with pseudoexfoliative glaucoma (PXG), patients with primary open-angle glaucoma (POAG), and controls. Methods. A total of 50 PXG patients (50 eyes) and 56 POAG patients (56 eyes) were selected as the PXG group and the POAG group, respectively, in this case-control study. A total of 54 age-, gender-, IOP-, and axial length-matched healthy individuals (54 eyes) were selected as the control group. Enhanced-depth imaging-optical coherence tomography (EDI-OCT) was used to measure and analyze the choroidal thicknesses and volumes in 9 macular regions of all subjects. Results. The choroidal thicknesses in the central subfield (CSM), temporal inner macula (TIM), inferior inner macula (IIM), and temporal outer macula (TOM) and the mean macular choroidal thickness were significantly thinner in the PXG group than in the control group (all P<0.05). The choroidal volumes in the TIM, IIM, and TOM and the mean macular choroidal volume were significantly smaller in the PXG group than in the control group (all P<0.05). The choroidal thicknesses in the CSM and IIM and the mean macular choroidal thickness were significantly thinner in the PXG group than in the POAG group (all P<0.05). The choroidal volumes in the IIM and TOM and the mean macular choroidal volume were significantly smaller in the PXG group than in the POAG group (all P<0.05). Multivariable linear regression analysis showed that the mean macular choroidal thickness was significantly thinner in association with older subjects and longer axial length eyes. There was no association between the macular choroidal thickness of various macular regions and visual field mean defect (MD) in groups PXG and POAG (all P>0.05). Conclusions. The macular choroidal thicknesses and volumes (inferior and temporal) in PXG patients were thinner and smaller than those in POAG patients and healthy individuals. The role of choroidal thickness changes in the course of PXG remains unclear. A future prospective study is needed to better define these changes in PXG patients.Fan LiYiming HuoLihua MaQing ZhangHengli ZhangXiaowei YanYulei GengGuangxian TangHindawi LimitedarticleOphthalmologyRE1-994ENJournal of Ophthalmology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Fan Li Yiming Huo Lihua Ma Qing Zhang Hengli Zhang Xiaowei Yan Yulei Geng Guangxian Tang Clinical Analysis of Macular Choroidal Thickness in Pseudoexfoliative Glaucoma and Primary Open-Angle Glaucoma
description	Purpose. To evaluate the differences in macular choroidal thickness and volume among patients with pseudoexfoliative glaucoma (PXG), patients with primary open-angle glaucoma (POAG), and controls. Methods. A total of 50 PXG patients (50 eyes) and 56 POAG patients (56 eyes) were selected as the PXG group and the POAG group, respectively, in this case-control study. A total of 54 age-, gender-, IOP-, and axial length-matched healthy individuals (54 eyes) were selected as the control group. Enhanced-depth imaging-optical coherence tomography (EDI-OCT) was used to measure and analyze the choroidal thicknesses and volumes in 9 macular regions of all subjects. Results. The choroidal thicknesses in the central subfield (CSM), temporal inner macula (TIM), inferior inner macula (IIM), and temporal outer macula (TOM) and the mean macular choroidal thickness were significantly thinner in the PXG group than in the control group (all P<0.05). The choroidal volumes in the TIM, IIM, and TOM and the mean macular choroidal volume were significantly smaller in the PXG group than in the control group (all P<0.05). The choroidal thicknesses in the CSM and IIM and the mean macular choroidal thickness were significantly thinner in the PXG group than in the POAG group (all P<0.05). The choroidal volumes in the IIM and TOM and the mean macular choroidal volume were significantly smaller in the PXG group than in the POAG group (all P<0.05). Multivariable linear regression analysis showed that the mean macular choroidal thickness was significantly thinner in association with older subjects and longer axial length eyes. There was no association between the macular choroidal thickness of various macular regions and visual field mean defect (MD) in groups PXG and POAG (all P>0.05). Conclusions. The macular choroidal thicknesses and volumes (inferior and temporal) in PXG patients were thinner and smaller than those in POAG patients and healthy individuals. The role of choroidal thickness changes in the course of PXG remains unclear. A future prospective study is needed to better define these changes in PXG patients.
format	article
author	Fan Li Yiming Huo Lihua Ma Qing Zhang Hengli Zhang Xiaowei Yan Yulei Geng Guangxian Tang
author_facet	Fan Li Yiming Huo Lihua Ma Qing Zhang Hengli Zhang Xiaowei Yan Yulei Geng Guangxian Tang
author_sort	Fan Li
title	Clinical Analysis of Macular Choroidal Thickness in Pseudoexfoliative Glaucoma and Primary Open-Angle Glaucoma
title_short	Clinical Analysis of Macular Choroidal Thickness in Pseudoexfoliative Glaucoma and Primary Open-Angle Glaucoma
title_full	Clinical Analysis of Macular Choroidal Thickness in Pseudoexfoliative Glaucoma and Primary Open-Angle Glaucoma
title_fullStr	Clinical Analysis of Macular Choroidal Thickness in Pseudoexfoliative Glaucoma and Primary Open-Angle Glaucoma
title_full_unstemmed	Clinical Analysis of Macular Choroidal Thickness in Pseudoexfoliative Glaucoma and Primary Open-Angle Glaucoma
title_sort	clinical analysis of macular choroidal thickness in pseudoexfoliative glaucoma and primary open-angle glaucoma
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/372ab2e246d048cfb65ef84101bbf421
work_keys_str_mv	AT fanli clinicalanalysisofmacularchoroidalthicknessinpseudoexfoliativeglaucomaandprimaryopenangleglaucoma AT yiminghuo clinicalanalysisofmacularchoroidalthicknessinpseudoexfoliativeglaucomaandprimaryopenangleglaucoma AT lihuama clinicalanalysisofmacularchoroidalthicknessinpseudoexfoliativeglaucomaandprimaryopenangleglaucoma AT qingzhang clinicalanalysisofmacularchoroidalthicknessinpseudoexfoliativeglaucomaandprimaryopenangleglaucoma AT henglizhang clinicalanalysisofmacularchoroidalthicknessinpseudoexfoliativeglaucomaandprimaryopenangleglaucoma AT xiaoweiyan clinicalanalysisofmacularchoroidalthicknessinpseudoexfoliativeglaucomaandprimaryopenangleglaucoma AT yuleigeng clinicalanalysisofmacularchoroidalthicknessinpseudoexfoliativeglaucomaandprimaryopenangleglaucoma AT guangxiantang clinicalanalysisofmacularchoroidalthicknessinpseudoexfoliativeglaucomaandprimaryopenangleglaucoma
_version_	1718407762467094528

Clinical Analysis of Macular Choroidal Thickness in Pseudoexfoliative Glaucoma and Primary Open-Angle Glaucoma

Ejemplares similares