Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors

Abstract Background Gastroesophageal reflux disease (GERD) is associated with lower esophageal sphincter (LES) incompetence. In some patients, GERD is refractory to acid reduction therapy which is the main treatment for GERD. So far, medications that can increase LES tone are few. Arecae pericarpium...

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Autores principales:	Shu-Leei Tey, Chi-Ying Li, Li-Wei Lin, Li-Ching Chang, Yea-Ling Chen, Fang-Rong Chang, San-Nan Yang, Ching-Chung Tsai
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Arecae pericarpium Lower esophageal sphincter Motility Muscarinic receptor Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/372b0019ab3546e48b2e184af8a95640
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spelling	oai:doaj.org-article:372b0019ab3546e48b2e184af8a956402021-11-08T11:14:05ZArecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors10.1186/s12906-021-03442-82662-7671https://doaj.org/article/372b0019ab3546e48b2e184af8a956402021-11-01T00:00:00Zhttps://doi.org/10.1186/s12906-021-03442-8https://doaj.org/toc/2662-7671Abstract Background Gastroesophageal reflux disease (GERD) is associated with lower esophageal sphincter (LES) incompetence. In some patients, GERD is refractory to acid reduction therapy which is the main treatment for GERD. So far, medications that can increase LES tone are few. Arecae pericarpium (A. pericarpium) is a medication in Traditional Chinese Medicine known to promote intestinal motility. Methods We investigated the effect of A. pericarpium extracts on porcine LES motility. In addition, we used tetrodotoxin (TTX) and atropine to study the underlying mechanism of A. pericarpium extracts-induced contractions of LES. Results The results of this study showed that A. pericarpium extracts and their main active ingredient, arecoline, can induce the contractions of porcine LES sling and clasp muscles in a dose-response manner. TTX did not have an inhibitory effect on the contractions induced by A. pericarpium extracts and arecoline in LES. However, atropine significantly inhibited A. pericarpium extracts- and arecoline-induced contractions of LES. Conclusion A. pericarpium extracts can induce the contractions of porcine LES in a dose dependent manner, possibly through muscarinic receptors, and hence, may be worth developing as an alternative therapy for GERD.Shu-Leei TeyChi-Ying LiLi-Wei LinLi-Ching ChangYea-Ling ChenFang-Rong ChangSan-Nan YangChing-Chung TsaiBMCarticleArecae pericarpiumLower esophageal sphincterMotilityMuscarinic receptorOther systems of medicineRZ201-999ENBMC Complementary Medicine and Therapies, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arecae pericarpium Lower esophageal sphincter Motility Muscarinic receptor Other systems of medicine RZ201-999
spellingShingle	Arecae pericarpium Lower esophageal sphincter Motility Muscarinic receptor Other systems of medicine RZ201-999 Shu-Leei Tey Chi-Ying Li Li-Wei Lin Li-Ching Chang Yea-Ling Chen Fang-Rong Chang San-Nan Yang Ching-Chung Tsai Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors
description	Abstract Background Gastroesophageal reflux disease (GERD) is associated with lower esophageal sphincter (LES) incompetence. In some patients, GERD is refractory to acid reduction therapy which is the main treatment for GERD. So far, medications that can increase LES tone are few. Arecae pericarpium (A. pericarpium) is a medication in Traditional Chinese Medicine known to promote intestinal motility. Methods We investigated the effect of A. pericarpium extracts on porcine LES motility. In addition, we used tetrodotoxin (TTX) and atropine to study the underlying mechanism of A. pericarpium extracts-induced contractions of LES. Results The results of this study showed that A. pericarpium extracts and their main active ingredient, arecoline, can induce the contractions of porcine LES sling and clasp muscles in a dose-response manner. TTX did not have an inhibitory effect on the contractions induced by A. pericarpium extracts and arecoline in LES. However, atropine significantly inhibited A. pericarpium extracts- and arecoline-induced contractions of LES. Conclusion A. pericarpium extracts can induce the contractions of porcine LES in a dose dependent manner, possibly through muscarinic receptors, and hence, may be worth developing as an alternative therapy for GERD.
format	article
author	Shu-Leei Tey Chi-Ying Li Li-Wei Lin Li-Ching Chang Yea-Ling Chen Fang-Rong Chang San-Nan Yang Ching-Chung Tsai
author_facet	Shu-Leei Tey Chi-Ying Li Li-Wei Lin Li-Ching Chang Yea-Ling Chen Fang-Rong Chang San-Nan Yang Ching-Chung Tsai
author_sort	Shu-Leei Tey
title	Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors
title_short	Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors
title_full	Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors
title_fullStr	Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors
title_full_unstemmed	Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors
title_sort	arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors
publisher	BMC
publishDate	2021
url	https://doaj.org/article/372b0019ab3546e48b2e184af8a95640
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Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors

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