Graphene-triphenyl phosphate (TPP) co-exposure in the marine environment: Interference with metabolism and immune regulation in mussel Mytilus galloprovincialis

Both immune regulation and endocrine systems are great challenges to marine organisms, and effective protocols for determining these adverse outcome pathways are limited, especially in vivo. The increasing usage of graphene nanomaterials can lead to the frequent exposure to marine organisms. Triphen...

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Autores principales:	Fei Li, Xiangjing Meng, Xiaoqing Wang, Chenglong Ji, Huifeng Wu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Nanomaterials Graphene Organophosphorus ester (OPEs) Mytilus Joint effects Multi-omics Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/3731c62fecb64ee9ab0c04675866c8d6
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spelling	oai:doaj.org-article:3731c62fecb64ee9ab0c04675866c8d62021-11-06T04:16:20ZGraphene-triphenyl phosphate (TPP) co-exposure in the marine environment: Interference with metabolism and immune regulation in mussel Mytilus galloprovincialis0147-651310.1016/j.ecoenv.2021.112904https://doaj.org/article/3731c62fecb64ee9ab0c04675866c8d62021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321010162https://doaj.org/toc/0147-6513Both immune regulation and endocrine systems are great challenges to marine organisms, and effective protocols for determining these adverse outcome pathways are limited, especially in vivo. The increasing usage of graphene nanomaterials can lead to the frequent exposure to marine organisms. Triphenyl phosphate (TPP), an organophosphate flame retardant, is frequently detected in natural environments. In this study, the combined toxic effects of co-exposure to graphene and TPP was investigated in Mytilus galloprovincialis using computational toxicology and multi-omics technology. Noticeably, graphene could disturb the membrane stability and increase the tissue accumulation of TPP. The adsorption behavior of TPP on graphene could inhibit the surface activity of graphene. In the digestive gland, transcriptomics analysis revealed the down-regulated genes in graphene + TPP treatment, including glyceraldehyde-3-phosphate dehydrogenase (GAPDH), sorbitol dehydrogenase (SORD), glutathione s-transferase mu 3 (GSTM3) and 4-aminobutyrate aminotransferase (ABAT), were mainly associated with oxidative stress and energy metabolism. Moreover, metabolic responses indicated that graphene + TPP could cause disturbances in energy metabolism and osmotic regulation marked by differentially altered ATP, glucose and taurine in mussels. These data underline the need for further knowledge on the potential interactions of nanomaterials with existing contaminants in marine organisms.Fei LiXiangjing MengXiaoqing WangChenglong JiHuifeng WuElsevierarticleNanomaterialsGrapheneOrganophosphorus ester (OPEs)MytilusJoint effectsMulti-omicsEnvironmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 227, Iss , Pp 112904- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanomaterials Graphene Organophosphorus ester (OPEs) Mytilus Joint effects Multi-omics Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Nanomaterials Graphene Organophosphorus ester (OPEs) Mytilus Joint effects Multi-omics Environmental pollution TD172-193.5 Environmental sciences GE1-350 Fei Li Xiangjing Meng Xiaoqing Wang Chenglong Ji Huifeng Wu Graphene-triphenyl phosphate (TPP) co-exposure in the marine environment: Interference with metabolism and immune regulation in mussel Mytilus galloprovincialis
description	Both immune regulation and endocrine systems are great challenges to marine organisms, and effective protocols for determining these adverse outcome pathways are limited, especially in vivo. The increasing usage of graphene nanomaterials can lead to the frequent exposure to marine organisms. Triphenyl phosphate (TPP), an organophosphate flame retardant, is frequently detected in natural environments. In this study, the combined toxic effects of co-exposure to graphene and TPP was investigated in Mytilus galloprovincialis using computational toxicology and multi-omics technology. Noticeably, graphene could disturb the membrane stability and increase the tissue accumulation of TPP. The adsorption behavior of TPP on graphene could inhibit the surface activity of graphene. In the digestive gland, transcriptomics analysis revealed the down-regulated genes in graphene + TPP treatment, including glyceraldehyde-3-phosphate dehydrogenase (GAPDH), sorbitol dehydrogenase (SORD), glutathione s-transferase mu 3 (GSTM3) and 4-aminobutyrate aminotransferase (ABAT), were mainly associated with oxidative stress and energy metabolism. Moreover, metabolic responses indicated that graphene + TPP could cause disturbances in energy metabolism and osmotic regulation marked by differentially altered ATP, glucose and taurine in mussels. These data underline the need for further knowledge on the potential interactions of nanomaterials with existing contaminants in marine organisms.
format	article
author	Fei Li Xiangjing Meng Xiaoqing Wang Chenglong Ji Huifeng Wu
author_facet	Fei Li Xiangjing Meng Xiaoqing Wang Chenglong Ji Huifeng Wu
author_sort	Fei Li
title	Graphene-triphenyl phosphate (TPP) co-exposure in the marine environment: Interference with metabolism and immune regulation in mussel Mytilus galloprovincialis
title_short	Graphene-triphenyl phosphate (TPP) co-exposure in the marine environment: Interference with metabolism and immune regulation in mussel Mytilus galloprovincialis
title_full	Graphene-triphenyl phosphate (TPP) co-exposure in the marine environment: Interference with metabolism and immune regulation in mussel Mytilus galloprovincialis
title_fullStr	Graphene-triphenyl phosphate (TPP) co-exposure in the marine environment: Interference with metabolism and immune regulation in mussel Mytilus galloprovincialis
title_full_unstemmed	Graphene-triphenyl phosphate (TPP) co-exposure in the marine environment: Interference with metabolism and immune regulation in mussel Mytilus galloprovincialis
title_sort	graphene-triphenyl phosphate (tpp) co-exposure in the marine environment: interference with metabolism and immune regulation in mussel mytilus galloprovincialis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/3731c62fecb64ee9ab0c04675866c8d6
work_keys_str_mv	AT feili graphenetriphenylphosphatetppcoexposureinthemarineenvironmentinterferencewithmetabolismandimmuneregulationinmusselmytilusgalloprovincialis AT xiangjingmeng graphenetriphenylphosphatetppcoexposureinthemarineenvironmentinterferencewithmetabolismandimmuneregulationinmusselmytilusgalloprovincialis AT xiaoqingwang graphenetriphenylphosphatetppcoexposureinthemarineenvironmentinterferencewithmetabolismandimmuneregulationinmusselmytilusgalloprovincialis AT chenglongji graphenetriphenylphosphatetppcoexposureinthemarineenvironmentinterferencewithmetabolismandimmuneregulationinmusselmytilusgalloprovincialis AT huifengwu graphenetriphenylphosphatetppcoexposureinthemarineenvironmentinterferencewithmetabolismandimmuneregulationinmusselmytilusgalloprovincialis
_version_	1718443909534711808

Graphene-triphenyl phosphate (TPP) co-exposure in the marine environment: Interference with metabolism and immune regulation in mussel Mytilus galloprovincialis

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