A second DNA binding site in human BRCA2 promotes homologous recombination

BRCA2 is a well-characterized central player in homologous recombination in which it functions as the RAD51 loader. Here the authors identify an N-terminal region of BRCA2 that binds DNA and promotes efficient DNA repair.

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Autores principales:	Catharina von Nicolai, Åsa Ehlén, Charlotte Martin, Xiaodong Zhang, Aura Carreira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3736af5edec74ca0b1a798200ee895a5
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spelling	oai:doaj.org-article:3736af5edec74ca0b1a798200ee895a52021-12-02T16:50:14ZA second DNA binding site in human BRCA2 promotes homologous recombination10.1038/ncomms128132041-1723https://doaj.org/article/3736af5edec74ca0b1a798200ee895a52016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12813https://doaj.org/toc/2041-1723BRCA2 is a well-characterized central player in homologous recombination in which it functions as the RAD51 loader. Here the authors identify an N-terminal region of BRCA2 that binds DNA and promotes efficient DNA repair.Catharina von NicolaiÅsa EhlénCharlotte MartinXiaodong ZhangAura CarreiraNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Catharina von Nicolai Åsa Ehlén Charlotte Martin Xiaodong Zhang Aura Carreira A second DNA binding site in human BRCA2 promotes homologous recombination
description	BRCA2 is a well-characterized central player in homologous recombination in which it functions as the RAD51 loader. Here the authors identify an N-terminal region of BRCA2 that binds DNA and promotes efficient DNA repair.
format	article
author	Catharina von Nicolai Åsa Ehlén Charlotte Martin Xiaodong Zhang Aura Carreira
author_facet	Catharina von Nicolai Åsa Ehlén Charlotte Martin Xiaodong Zhang Aura Carreira
author_sort	Catharina von Nicolai
title	A second DNA binding site in human BRCA2 promotes homologous recombination
title_short	A second DNA binding site in human BRCA2 promotes homologous recombination
title_full	A second DNA binding site in human BRCA2 promotes homologous recombination
title_fullStr	A second DNA binding site in human BRCA2 promotes homologous recombination
title_full_unstemmed	A second DNA binding site in human BRCA2 promotes homologous recombination
title_sort	second dna binding site in human brca2 promotes homologous recombination
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3736af5edec74ca0b1a798200ee895a5
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A second DNA binding site in human BRCA2 promotes homologous recombination

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