AST to Platelet Ratio Index (APRI) is an easy-to-use predictor score for cardiovascular risk in metabolic subjects

Abstract Visceral obesity is characterized by a low-grade inflammatory systemic state that contributes to the genesis of non-alcoholic fatty liver disease (NAFLD), frequently associated with liver fibrosis. Non-invasive serum markers have recently emerged as reliable, easy-to-use scores to predict l...

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Autores principales:	Carlo De Matteis, Marica Cariello, Giusi Graziano, Stefano Battaglia, Patrizia Suppressa, Giuseppina Piazzolla, Carlo Sabbà, Antonio Moschetta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/373c5b325d814dd8a64f38aa4619a4e3
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spelling	oai:doaj.org-article:373c5b325d814dd8a64f38aa4619a4e32021-12-02T16:17:21ZAST to Platelet Ratio Index (APRI) is an easy-to-use predictor score for cardiovascular risk in metabolic subjects10.1038/s41598-021-94277-32045-2322https://doaj.org/article/373c5b325d814dd8a64f38aa4619a4e32021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94277-3https://doaj.org/toc/2045-2322Abstract Visceral obesity is characterized by a low-grade inflammatory systemic state that contributes to the genesis of non-alcoholic fatty liver disease (NAFLD), frequently associated with liver fibrosis. Non-invasive serum markers have recently emerged as reliable, easy-to-use scores to predict liver fibrosis. NAFLD is often linked to metabolic and cardiovascular risk. Thus, in this cross-sectional study, we investigated in a population of 1225 subjects if AST to Platelet Ratio Index (APRI), one of the non-invasive liver fibrosis serum markers, can predict cardiovascular risk (CVR). APRI has been previously validated as an efficient score to predict liver fibrosis in viral hepatitis patients with a cut-off of 0.5 for fibrosis and 1.5 for cirrhosis. Our study showed that APRI significantly correlates with CVR and determines, when elevated, a significant increase in CVR for both genders, especially females. This spike in CVR, observed when APRI is elevated, is relatively high in patients in the age of 51–65 years, but it is significantly higher in younger and premenopausal women, approaching risk values usually typical of men at the same age. Taken together, our data highlighted the role of APRI as a reliable predictor easy-to-use score for CVR in metabolic patients.Carlo De MatteisMarica CarielloGiusi GrazianoStefano BattagliaPatrizia SuppressaGiuseppina PiazzollaCarlo SabbàAntonio MoschettaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carlo De Matteis Marica Cariello Giusi Graziano Stefano Battaglia Patrizia Suppressa Giuseppina Piazzolla Carlo Sabbà Antonio Moschetta AST to Platelet Ratio Index (APRI) is an easy-to-use predictor score for cardiovascular risk in metabolic subjects
description	Abstract Visceral obesity is characterized by a low-grade inflammatory systemic state that contributes to the genesis of non-alcoholic fatty liver disease (NAFLD), frequently associated with liver fibrosis. Non-invasive serum markers have recently emerged as reliable, easy-to-use scores to predict liver fibrosis. NAFLD is often linked to metabolic and cardiovascular risk. Thus, in this cross-sectional study, we investigated in a population of 1225 subjects if AST to Platelet Ratio Index (APRI), one of the non-invasive liver fibrosis serum markers, can predict cardiovascular risk (CVR). APRI has been previously validated as an efficient score to predict liver fibrosis in viral hepatitis patients with a cut-off of 0.5 for fibrosis and 1.5 for cirrhosis. Our study showed that APRI significantly correlates with CVR and determines, when elevated, a significant increase in CVR for both genders, especially females. This spike in CVR, observed when APRI is elevated, is relatively high in patients in the age of 51–65 years, but it is significantly higher in younger and premenopausal women, approaching risk values usually typical of men at the same age. Taken together, our data highlighted the role of APRI as a reliable predictor easy-to-use score for CVR in metabolic patients.
format	article
author	Carlo De Matteis Marica Cariello Giusi Graziano Stefano Battaglia Patrizia Suppressa Giuseppina Piazzolla Carlo Sabbà Antonio Moschetta
author_facet	Carlo De Matteis Marica Cariello Giusi Graziano Stefano Battaglia Patrizia Suppressa Giuseppina Piazzolla Carlo Sabbà Antonio Moschetta
author_sort	Carlo De Matteis
title	AST to Platelet Ratio Index (APRI) is an easy-to-use predictor score for cardiovascular risk in metabolic subjects
title_short	AST to Platelet Ratio Index (APRI) is an easy-to-use predictor score for cardiovascular risk in metabolic subjects
title_full	AST to Platelet Ratio Index (APRI) is an easy-to-use predictor score for cardiovascular risk in metabolic subjects
title_fullStr	AST to Platelet Ratio Index (APRI) is an easy-to-use predictor score for cardiovascular risk in metabolic subjects
title_full_unstemmed	AST to Platelet Ratio Index (APRI) is an easy-to-use predictor score for cardiovascular risk in metabolic subjects
title_sort	ast to platelet ratio index (apri) is an easy-to-use predictor score for cardiovascular risk in metabolic subjects
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/373c5b325d814dd8a64f38aa4619a4e3
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AST to Platelet Ratio Index (APRI) is an easy-to-use predictor score for cardiovascular risk in metabolic subjects

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