Increased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study
Murat Beyazyüz,1 Tarkan Küfeciler,2 Leyla Bulut,3 Cüneyt Ünsal,1 Yakup Albayrak,1 Esra Soydaş Akyol,4 Saliha Baykal,1 Murat Kuloglu,5 Kenji Hashimoto61Department of Psychiatry, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey; 2Department of Emergency...
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Dove Medical Press
2016
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oai:doaj.org-article:373cdc0d13944cff8656b135170408482021-12-02T01:55:35ZIncreased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study1178-2021https://doaj.org/article/373cdc0d13944cff8656b135170408482016-05-01T00:00:00Zhttps://www.dovepress.com/increased-serum-levels-of-apoptosis-in-deficit-syndrome-schizophrenia--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Murat Beyazyüz,1 Tarkan Küfeciler,2 Leyla Bulut,3 Cüneyt Ünsal,1 Yakup Albayrak,1 Esra Soydaş Akyol,4 Saliha Baykal,1 Murat Kuloglu,5 Kenji Hashimoto61Department of Psychiatry, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey; 2Department of Emergency Medicine, Çekirge State Hospital, Bursa, Turkey; 3Department of Biochemistry, Okmeydani Education and Research Hospital, Istanbul, Turkey; 4Department of Psychiatry, Yenimahalle Education and Research Hospital, Ankara, Turkey; 5Department of Psychiatry, Faculty of Medicine, Akdeniz University, Antalya, Turkey; 6Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, JapanBackground: Schizophrenia is a chronic and debilitating disorder, the etiology of which remains unclear. Apoptosis is a programmed cell death mechanism that might be implicated in neuropsychiatric disorders, including schizophrenia. In this study, we aimed to compare the serum levels of apoptosis among deficit schizophrenia (DS) syndrome patients, nondeficit schizophrenia (NDS) patients, and healthy controls (HCs).Patients and methods: After the inclusion and exclusion criteria were applied, 23 DS patients, 46 NDS patients, and 33 HCs were included in the study. The serum apoptosis levels were measured using a quantitative sandwich enzyme immunoassay with human monoclonal antibodies directed against DNA and histones.Results: There was a significant difference among the three groups in terms of the levels of apoptosis (F2,96=16.58; P<0.001). The serum apoptosis levels in the DS and NDS groups were significantly higher than those in the HC group. Furthermore, the serum apoptosis levels in the DS group were significantly higher than the levels in the NDS group.Conclusion: This study suggests that increased levels of apoptosis may be implicated in the pathophysiology of DS syndrome. However, further studies are needed to support the role of apoptosis in DS.Keywords: apoptosis, etiology, deficit, psychosisBeyazyüz MKüfeciler TBulut LÜnsal CAlbayrak YAkyol ESBaykal SKuloglu MHashimoto KDove Medical PressarticleApoptosisDeficit syndromeSchizophreniaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1261-1268 (2016) |
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Apoptosis Deficit syndrome Schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Apoptosis Deficit syndrome Schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Beyazyüz M Küfeciler T Bulut L Ünsal C Albayrak Y Akyol ES Baykal S Kuloglu M Hashimoto K Increased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study |
| description |
Murat Beyazyüz,1 Tarkan Küfeciler,2 Leyla Bulut,3 Cüneyt Ünsal,1 Yakup Albayrak,1 Esra Soydaş Akyol,4 Saliha Baykal,1 Murat Kuloglu,5 Kenji Hashimoto61Department of Psychiatry, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey; 2Department of Emergency Medicine, Çekirge State Hospital, Bursa, Turkey; 3Department of Biochemistry, Okmeydani Education and Research Hospital, Istanbul, Turkey; 4Department of Psychiatry, Yenimahalle Education and Research Hospital, Ankara, Turkey; 5Department of Psychiatry, Faculty of Medicine, Akdeniz University, Antalya, Turkey; 6Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, JapanBackground: Schizophrenia is a chronic and debilitating disorder, the etiology of which remains unclear. Apoptosis is a programmed cell death mechanism that might be implicated in neuropsychiatric disorders, including schizophrenia. In this study, we aimed to compare the serum levels of apoptosis among deficit schizophrenia (DS) syndrome patients, nondeficit schizophrenia (NDS) patients, and healthy controls (HCs).Patients and methods: After the inclusion and exclusion criteria were applied, 23 DS patients, 46 NDS patients, and 33 HCs were included in the study. The serum apoptosis levels were measured using a quantitative sandwich enzyme immunoassay with human monoclonal antibodies directed against DNA and histones.Results: There was a significant difference among the three groups in terms of the levels of apoptosis (F2,96=16.58; P<0.001). The serum apoptosis levels in the DS and NDS groups were significantly higher than those in the HC group. Furthermore, the serum apoptosis levels in the DS group were significantly higher than the levels in the NDS group.Conclusion: This study suggests that increased levels of apoptosis may be implicated in the pathophysiology of DS syndrome. However, further studies are needed to support the role of apoptosis in DS.Keywords: apoptosis, etiology, deficit, psychosis |
| format |
article |
| author |
Beyazyüz M Küfeciler T Bulut L Ünsal C Albayrak Y Akyol ES Baykal S Kuloglu M Hashimoto K |
| author_facet |
Beyazyüz M Küfeciler T Bulut L Ünsal C Albayrak Y Akyol ES Baykal S Kuloglu M Hashimoto K |
| author_sort |
Beyazyüz M |
| title |
Increased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study |
| title_short |
Increased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study |
| title_full |
Increased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study |
| title_fullStr |
Increased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study |
| title_full_unstemmed |
Increased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study |
| title_sort |
increased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/373cdc0d13944cff8656b13517040848 |
| work_keys_str_mv |
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