MMP20-generated amelogenin cleavage products prevent formation of fan-shaped enamel malformations

Abstract Dental enamel forms extracellularly as thin ribbons of amorphous calcium phosphate (ACP) that initiate on dentin mineral in close proximity to the ameloblast distal membrane. Secreted proteins are critical for this process. Enam −/− and Ambn −/− mice fail to form enamel. We characterize ena...

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Autores principales: John D. Bartlett, Charles E. Smith, Yuanyuan Hu, Atsushi Ikeda, Mike Strauss, Tian Liang, Ya-Hsiang Hsu, Amanda H. Trout, David W. McComb, Rebecca C. Freeman, James P. Simmer, Jan C.-C. Hu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/373d5cee0dcd4f0582e0f4f3a8212285
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