Cardioprotection for Acute MI in Light of the CONDI2/ERIC-PPCI Trial: New Targets Needed

Protection against ischaemia–reperfusion injury after revascularisation in acute myocardial infarction remains an enigma. Many targets have been identified, but after the failure of the recent Effect of Remote Ischaemic Conditioning on Clinical Outcomes in ST-elevation Myocardial Infarction Patients...

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Autores principales:	Joel P Giblett, Heerajnarain Bulluck
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2020
Materias:	Surgery RD1-811 Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/3741efb2e11b441eba1d4af3de1e62cf
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spelling	oai:doaj.org-article:3741efb2e11b441eba1d4af3de1e62cf2021-12-04T16:03:32ZCardioprotection for Acute MI in Light of the CONDI2/ERIC-PPCI Trial: New Targets Needed10.15420/icr.2020.011756-14851756-1477https://doaj.org/article/3741efb2e11b441eba1d4af3de1e62cf2020-08-01T00:00:00Zhttps://www.icrjournal.com/articles/cardioprotection-for-acute-mi-in-lighthttps://doaj.org/toc/1756-1477https://doaj.org/toc/1756-1485Protection against ischaemia–reperfusion injury after revascularisation in acute myocardial infarction remains an enigma. Many targets have been identified, but after the failure of the recent Effect of Remote Ischaemic Conditioning on Clinical Outcomes in ST-elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention (CONDI2/ERIC-PPCI) trial to show translation to clinical benefit, there is still no pharmacological or mechanical strategy that has translated to clinical practice. This article addresses the results of the CONDI2/ERIC-PPCI trial in the context of previous studies of ischaemic conditioning, and then considers the prospects for other potential targets of cardioprotection. Finally, the authors examine the pitfalls and challenges in trial design for future investigation of cardioprotective strategies. In particular, this article highlights the need for careful endpoint and patient selection, as well as the need to pay attention to the biology of cardioprotection during the study.Joel P GiblettHeerajnarain BulluckRadcliffe Medical MediaarticleSurgeryRD1-811Diseases of the circulatory (Cardiovascular) systemRC666-701ENInterventional Cardiology: Reviews, Research, Resources, Vol 15, Iss , Pp - (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Surgery RD1-811 Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Surgery RD1-811 Diseases of the circulatory (Cardiovascular) system RC666-701 Joel P Giblett Heerajnarain Bulluck Cardioprotection for Acute MI in Light of the CONDI2/ERIC-PPCI Trial: New Targets Needed
description	Protection against ischaemia–reperfusion injury after revascularisation in acute myocardial infarction remains an enigma. Many targets have been identified, but after the failure of the recent Effect of Remote Ischaemic Conditioning on Clinical Outcomes in ST-elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention (CONDI2/ERIC-PPCI) trial to show translation to clinical benefit, there is still no pharmacological or mechanical strategy that has translated to clinical practice. This article addresses the results of the CONDI2/ERIC-PPCI trial in the context of previous studies of ischaemic conditioning, and then considers the prospects for other potential targets of cardioprotection. Finally, the authors examine the pitfalls and challenges in trial design for future investigation of cardioprotective strategies. In particular, this article highlights the need for careful endpoint and patient selection, as well as the need to pay attention to the biology of cardioprotection during the study.
format	article
author	Joel P Giblett Heerajnarain Bulluck
author_facet	Joel P Giblett Heerajnarain Bulluck
author_sort	Joel P Giblett
title	Cardioprotection for Acute MI in Light of the CONDI2/ERIC-PPCI Trial: New Targets Needed
title_short	Cardioprotection for Acute MI in Light of the CONDI2/ERIC-PPCI Trial: New Targets Needed
title_full	Cardioprotection for Acute MI in Light of the CONDI2/ERIC-PPCI Trial: New Targets Needed
title_fullStr	Cardioprotection for Acute MI in Light of the CONDI2/ERIC-PPCI Trial: New Targets Needed
title_full_unstemmed	Cardioprotection for Acute MI in Light of the CONDI2/ERIC-PPCI Trial: New Targets Needed
title_sort	cardioprotection for acute mi in light of the condi2/eric-ppci trial: new targets needed
publisher	Radcliffe Medical Media
publishDate	2020
url	https://doaj.org/article/3741efb2e11b441eba1d4af3de1e62cf
work_keys_str_mv	AT joelpgiblett cardioprotectionforacutemiinlightofthecondi2ericppcitrialnewtargetsneeded AT heerajnarainbulluck cardioprotectionforacutemiinlightofthecondi2ericppcitrialnewtargetsneeded
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Cardioprotection for Acute MI in Light of the CONDI2/ERIC-PPCI Trial: New Targets Needed

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