PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness

Stem cells are found in many tumour types and are thought to be partially responsible for cell survival following therapy. Here, the authors show that PCNA-associated factor, PAF, contributes to stemness in breast cancer cells and pharmacological targeting of PAF reduces mammosphere formation.

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Autores principales:	Xin Wang, Youn-Sang Jung, Sohee Jun, Sunhye Lee, Wenqi Wang, Andrea Schneider, Young Sun Oh, Steven H. Lin, Bum-Joon Park, Junjie Chen, Khandan Keyomarsi, Jae-Il Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/37476cf6f4614676ad1403d5c4213f50
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spelling	oai:doaj.org-article:37476cf6f4614676ad1403d5c4213f502021-12-02T17:33:20ZPAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness10.1038/ncomms106332041-1723https://doaj.org/article/37476cf6f4614676ad1403d5c4213f502016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10633https://doaj.org/toc/2041-1723Stem cells are found in many tumour types and are thought to be partially responsible for cell survival following therapy. Here, the authors show that PCNA-associated factor, PAF, contributes to stemness in breast cancer cells and pharmacological targeting of PAF reduces mammosphere formation.Xin WangYoun-Sang JungSohee JunSunhye LeeWenqi WangAndrea SchneiderYoung Sun OhSteven H. LinBum-Joon ParkJunjie ChenKhandan KeyomarsiJae-Il ParkNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xin Wang Youn-Sang Jung Sohee Jun Sunhye Lee Wenqi Wang Andrea Schneider Young Sun Oh Steven H. Lin Bum-Joon Park Junjie Chen Khandan Keyomarsi Jae-Il Park PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness
description	Stem cells are found in many tumour types and are thought to be partially responsible for cell survival following therapy. Here, the authors show that PCNA-associated factor, PAF, contributes to stemness in breast cancer cells and pharmacological targeting of PAF reduces mammosphere formation.
format	article
author	Xin Wang Youn-Sang Jung Sohee Jun Sunhye Lee Wenqi Wang Andrea Schneider Young Sun Oh Steven H. Lin Bum-Joon Park Junjie Chen Khandan Keyomarsi Jae-Il Park
author_facet	Xin Wang Youn-Sang Jung Sohee Jun Sunhye Lee Wenqi Wang Andrea Schneider Young Sun Oh Steven H. Lin Bum-Joon Park Junjie Chen Khandan Keyomarsi Jae-Il Park
author_sort	Xin Wang
title	PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness
title_short	PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness
title_full	PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness
title_fullStr	PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness
title_full_unstemmed	PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness
title_sort	paf-wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/37476cf6f4614676ad1403d5c4213f50
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PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness

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