Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites

Graft versus host disease (GvHD) still hinders allogeneic hematopoietic stem cell transplantation. Here, the authors use metabolomics to analyze two cohorts of paired transplant recipients and donors, identifying significant differences in both host- and microbiota-derived metabolites.

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Autores principales: David Michonneau, Eleonora Latis, Emmanuel Curis, Laetitia Dubouchet, Sivapriya Ramamoorthy, Brian Ingram, Régis Peffault de Latour, Marie Robin, Flore Sicre de Fontbrune, Sylvie Chevret, Lars Rogge, Gérard Socié
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/3747dae6cbe941c7a74462b4f4f93fd1
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spelling oai:doaj.org-article:3747dae6cbe941c7a74462b4f4f93fd12021-12-02T17:02:15ZMetabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites10.1038/s41467-019-13498-32041-1723https://doaj.org/article/3747dae6cbe941c7a74462b4f4f93fd12019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13498-3https://doaj.org/toc/2041-1723Graft versus host disease (GvHD) still hinders allogeneic hematopoietic stem cell transplantation. Here, the authors use metabolomics to analyze two cohorts of paired transplant recipients and donors, identifying significant differences in both host- and microbiota-derived metabolites.David MichonneauEleonora LatisEmmanuel CurisLaetitia DubouchetSivapriya RamamoorthyBrian IngramRégis Peffault de LatourMarie RobinFlore Sicre de FontbruneSylvie ChevretLars RoggeGérard SociéNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
David Michonneau
Eleonora Latis
Emmanuel Curis
Laetitia Dubouchet
Sivapriya Ramamoorthy
Brian Ingram
Régis Peffault de Latour
Marie Robin
Flore Sicre de Fontbrune
Sylvie Chevret
Lars Rogge
Gérard Socié
Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites
description Graft versus host disease (GvHD) still hinders allogeneic hematopoietic stem cell transplantation. Here, the authors use metabolomics to analyze two cohorts of paired transplant recipients and donors, identifying significant differences in both host- and microbiota-derived metabolites.
format article
author David Michonneau
Eleonora Latis
Emmanuel Curis
Laetitia Dubouchet
Sivapriya Ramamoorthy
Brian Ingram
Régis Peffault de Latour
Marie Robin
Flore Sicre de Fontbrune
Sylvie Chevret
Lars Rogge
Gérard Socié
author_facet David Michonneau
Eleonora Latis
Emmanuel Curis
Laetitia Dubouchet
Sivapriya Ramamoorthy
Brian Ingram
Régis Peffault de Latour
Marie Robin
Flore Sicre de Fontbrune
Sylvie Chevret
Lars Rogge
Gérard Socié
author_sort David Michonneau
title Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites
title_short Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites
title_full Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites
title_fullStr Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites
title_full_unstemmed Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites
title_sort metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/3747dae6cbe941c7a74462b4f4f93fd1
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