Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites

Graft versus host disease (GvHD) still hinders allogeneic hematopoietic stem cell transplantation. Here, the authors use metabolomics to analyze two cohorts of paired transplant recipients and donors, identifying significant differences in both host- and microbiota-derived metabolites.

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Main Authors:	David Michonneau, Eleonora Latis, Emmanuel Curis, Laetitia Dubouchet, Sivapriya Ramamoorthy, Brian Ingram, Régis Peffault de Latour, Marie Robin, Flore Sicre de Fontbrune, Sylvie Chevret, Lars Rogge, Gérard Socié
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/3747dae6cbe941c7a74462b4f4f93fd1
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spelling	oai:doaj.org-article:3747dae6cbe941c7a74462b4f4f93fd12021-12-02T17:02:15ZMetabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites10.1038/s41467-019-13498-32041-1723https://doaj.org/article/3747dae6cbe941c7a74462b4f4f93fd12019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13498-3https://doaj.org/toc/2041-1723Graft versus host disease (GvHD) still hinders allogeneic hematopoietic stem cell transplantation. Here, the authors use metabolomics to analyze two cohorts of paired transplant recipients and donors, identifying significant differences in both host- and microbiota-derived metabolites.David MichonneauEleonora LatisEmmanuel CurisLaetitia DubouchetSivapriya RamamoorthyBrian IngramRégis Peffault de LatourMarie RobinFlore Sicre de FontbruneSylvie ChevretLars RoggeGérard SociéNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David Michonneau Eleonora Latis Emmanuel Curis Laetitia Dubouchet Sivapriya Ramamoorthy Brian Ingram Régis Peffault de Latour Marie Robin Flore Sicre de Fontbrune Sylvie Chevret Lars Rogge Gérard Socié Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites
description	Graft versus host disease (GvHD) still hinders allogeneic hematopoietic stem cell transplantation. Here, the authors use metabolomics to analyze two cohorts of paired transplant recipients and donors, identifying significant differences in both host- and microbiota-derived metabolites.
format	article
author	David Michonneau Eleonora Latis Emmanuel Curis Laetitia Dubouchet Sivapriya Ramamoorthy Brian Ingram Régis Peffault de Latour Marie Robin Flore Sicre de Fontbrune Sylvie Chevret Lars Rogge Gérard Socié
author_facet	David Michonneau Eleonora Latis Emmanuel Curis Laetitia Dubouchet Sivapriya Ramamoorthy Brian Ingram Régis Peffault de Latour Marie Robin Flore Sicre de Fontbrune Sylvie Chevret Lars Rogge Gérard Socié
author_sort	David Michonneau
title	Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites
title_short	Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites
title_full	Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites
title_fullStr	Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites
title_full_unstemmed	Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites
title_sort	metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3747dae6cbe941c7a74462b4f4f93fd1
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Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites

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