<i>Euphausia pacifica</i> (North Pacific Krill): Review of Chemical Features and Potential Benefits of 8-HEPE against Metabolic Syndrome, Dyslipidemia, NAFLD, and Atherosclerosis

<i>Euphausia pacifica</i> (North Pacific Krill): Review of Chemical Features and Potential Benefits of 8-HEPE against Metabolic Syndrome, Dyslipidemia, NAFLD, and Atherosclerosis

Marine n-3 fatty acids are well known to have health benefits. Recently, krill oil, which contains phospholipids, has been in the spotlight as an n-3 PUFA-containing oil. <i>Euphausia pacifica</i> (<i>E. pacifica</i>), also called North Pacific krill, is a small, red crustace...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Nanae Ishida, Hidetoshi Yamada, Masamichi Hirose
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
<i>Euphausia pacifica</i>
8-HEPE
N-3 polyunsaturated fatty acids
nonalcoholic fatty liver disease
Nutrition. Foods and food supply
TX341-641
Acceso en línea:https://doaj.org/article/374a490d481e4919a7237d73f1a9ffad
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:374a490d481e4919a7237d73f1a9ffad
record_format dspace
spelling oai:doaj.org-article:374a490d481e4919a7237d73f1a9ffad2021-11-25T18:33:52Z<i>Euphausia pacifica</i> (North Pacific Krill): Review of Chemical Features and Potential Benefits of 8-HEPE against Metabolic Syndrome, Dyslipidemia, NAFLD, and Atherosclerosis10.3390/nu131137652072-6643https://doaj.org/article/374a490d481e4919a7237d73f1a9ffad2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3765https://doaj.org/toc/2072-6643Marine n-3 fatty acids are well known to have health benefits. Recently, krill oil, which contains phospholipids, has been in the spotlight as an n-3 PUFA-containing oil. <i>Euphausia pacifica</i> (<i>E. pacifica</i>), also called North Pacific krill, is a small, red crustacean similar to shrimp that flourishes in the North Pacific Ocean. <i>E. pacifica</i> oil contains 8-hydroxyeicosapentaenoic acid (8-HEPE) at a level more than 10 times higher than <i>Euphausia superba</i> oil. 8-HEPE can activate the transcription of peroxisome proliferator-activated receptor alpha (PPARα), PPARγ, and PPARδ to levels 10, 5, and 3 times greater than eicosapentaenoic acid, respectively. 8-HEPE has beneficial effects against metabolic syndrome (reduction in body weight gain, visceral fat area, amount of gonadal white adipose tissue, and gonadal adipocyte cell size), dyslipidemia (reduction in serum triacylglycerol and low-density lipoprotein cholesterol and induction of serum high-density lipoprotein cholesterol), atherosclerosis, and nonalcoholic fatty liver disease (reduction in triglyceride accumulation and hepatic steatosis in the liver) in mice. Further studies should focus on the beneficial effects of North Pacific krill oil products and 8-HEPE on human health.Nanae IshidaHidetoshi YamadaMasamichi HiroseMDPI AGarticle<i>Euphausia pacifica</i>8-HEPEN-3 polyunsaturated fatty acidsnonalcoholic fatty liver diseaseNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3765, p 3765 (2021)
institution DOAJ
collection DOAJ
language EN
topic <i>Euphausia pacifica</i>
8-HEPE
N-3 polyunsaturated fatty acids
nonalcoholic fatty liver disease
Nutrition. Foods and food supply
TX341-641
spellingShingle <i>Euphausia pacifica</i>
8-HEPE
N-3 polyunsaturated fatty acids
nonalcoholic fatty liver disease
Nutrition. Foods and food supply
TX341-641
Nanae Ishida
Hidetoshi Yamada
Masamichi Hirose
<i>Euphausia pacifica</i> (North Pacific Krill): Review of Chemical Features and Potential Benefits of 8-HEPE against Metabolic Syndrome, Dyslipidemia, NAFLD, and Atherosclerosis
description Marine n-3 fatty acids are well known to have health benefits. Recently, krill oil, which contains phospholipids, has been in the spotlight as an n-3 PUFA-containing oil. <i>Euphausia pacifica</i> (<i>E. pacifica</i>), also called North Pacific krill, is a small, red crustacean similar to shrimp that flourishes in the North Pacific Ocean. <i>E. pacifica</i> oil contains 8-hydroxyeicosapentaenoic acid (8-HEPE) at a level more than 10 times higher than <i>Euphausia superba</i> oil. 8-HEPE can activate the transcription of peroxisome proliferator-activated receptor alpha (PPARα), PPARγ, and PPARδ to levels 10, 5, and 3 times greater than eicosapentaenoic acid, respectively. 8-HEPE has beneficial effects against metabolic syndrome (reduction in body weight gain, visceral fat area, amount of gonadal white adipose tissue, and gonadal adipocyte cell size), dyslipidemia (reduction in serum triacylglycerol and low-density lipoprotein cholesterol and induction of serum high-density lipoprotein cholesterol), atherosclerosis, and nonalcoholic fatty liver disease (reduction in triglyceride accumulation and hepatic steatosis in the liver) in mice. Further studies should focus on the beneficial effects of North Pacific krill oil products and 8-HEPE on human health.
format article
author Nanae Ishida
Hidetoshi Yamada
Masamichi Hirose
author_facet Nanae Ishida
Hidetoshi Yamada
Masamichi Hirose
author_sort Nanae Ishida
title <i>Euphausia pacifica</i> (North Pacific Krill): Review of Chemical Features and Potential Benefits of 8-HEPE against Metabolic Syndrome, Dyslipidemia, NAFLD, and Atherosclerosis
title_short <i>Euphausia pacifica</i> (North Pacific Krill): Review of Chemical Features and Potential Benefits of 8-HEPE against Metabolic Syndrome, Dyslipidemia, NAFLD, and Atherosclerosis
title_full <i>Euphausia pacifica</i> (North Pacific Krill): Review of Chemical Features and Potential Benefits of 8-HEPE against Metabolic Syndrome, Dyslipidemia, NAFLD, and Atherosclerosis
title_fullStr <i>Euphausia pacifica</i> (North Pacific Krill): Review of Chemical Features and Potential Benefits of 8-HEPE against Metabolic Syndrome, Dyslipidemia, NAFLD, and Atherosclerosis
title_full_unstemmed <i>Euphausia pacifica</i> (North Pacific Krill): Review of Chemical Features and Potential Benefits of 8-HEPE against Metabolic Syndrome, Dyslipidemia, NAFLD, and Atherosclerosis
title_sort <i>euphausia pacifica</i> (north pacific krill): review of chemical features and potential benefits of 8-hepe against metabolic syndrome, dyslipidemia, nafld, and atherosclerosis
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/374a490d481e4919a7237d73f1a9ffad
work_keys_str_mv AT nanaeishida ieuphausiapacificainorthpacifickrillreviewofchemicalfeaturesandpotentialbenefitsof8hepeagainstmetabolicsyndromedyslipidemianafldandatherosclerosis
AT hidetoshiyamada ieuphausiapacificainorthpacifickrillreviewofchemicalfeaturesandpotentialbenefitsof8hepeagainstmetabolicsyndromedyslipidemianafldandatherosclerosis
AT masamichihirose ieuphausiapacificainorthpacifickrillreviewofchemicalfeaturesandpotentialbenefitsof8hepeagainstmetabolicsyndromedyslipidemianafldandatherosclerosis
_version_ 1718410944875331584

Ejemplares similares