A new method for cancer detection based on diffusion reflection measurements of targeted gold nanorods

Rinat Ankri, Vital Peretz, Menachem Motiei, Rachela Popovtzer, Dror FixlerFaculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan 52900, IsraelAbstract: This paper presents a new method for cancer detection based on diffusion reflection measu...

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Autores principales: Ankri R, Peretz V, Motiei M, Popovtzer R, Fixler D
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2012
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Acceso en línea:https://doaj.org/article/374b24f94d494b588b8c310ec4aed851
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spelling oai:doaj.org-article:374b24f94d494b588b8c310ec4aed8512021-12-02T02:11:13ZA new method for cancer detection based on diffusion reflection measurements of targeted gold nanorods1176-91141178-2013https://doaj.org/article/374b24f94d494b588b8c310ec4aed8512012-01-01T00:00:00Zhttp://www.dovepress.com/a-new-method-for-cancer-detection-based-on-diffusion-reflection-measur-a9165https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Rinat Ankri, Vital Peretz, Menachem Motiei, Rachela Popovtzer, Dror FixlerFaculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan 52900, IsraelAbstract: This paper presents a new method for cancer detection based on diffusion reflection measurements. This method enables discrimination between cancerous and noncancerous tissues due to the intense light absorption of gold nanorods (GNRs), which are selectively targeted to squamous cell carcinoma head and neck cancer cells. Presented in this paper are tissue-like phantom and in vivo results that demonstrate the high sensitivity of diffusion reflection measurements to the absorption differences between the GNR-targeted cancerous tissue and normal, noncancerous tissue. This noninvasive and nonionizing optical detection method provides a highly sensitive, simple, and inexpensive tool for cancer detection.Keywords: molecular imaging, nanoparticles, EGFR targeted, tissues’ optical propertiesAnkri RPeretz VMotiei MPopovtzer RFixler DDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 449-455 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Ankri R
Peretz V
Motiei M
Popovtzer R
Fixler D
A new method for cancer detection based on diffusion reflection measurements of targeted gold nanorods
description Rinat Ankri, Vital Peretz, Menachem Motiei, Rachela Popovtzer, Dror FixlerFaculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan 52900, IsraelAbstract: This paper presents a new method for cancer detection based on diffusion reflection measurements. This method enables discrimination between cancerous and noncancerous tissues due to the intense light absorption of gold nanorods (GNRs), which are selectively targeted to squamous cell carcinoma head and neck cancer cells. Presented in this paper are tissue-like phantom and in vivo results that demonstrate the high sensitivity of diffusion reflection measurements to the absorption differences between the GNR-targeted cancerous tissue and normal, noncancerous tissue. This noninvasive and nonionizing optical detection method provides a highly sensitive, simple, and inexpensive tool for cancer detection.Keywords: molecular imaging, nanoparticles, EGFR targeted, tissues’ optical properties
format article
author Ankri R
Peretz V
Motiei M
Popovtzer R
Fixler D
author_facet Ankri R
Peretz V
Motiei M
Popovtzer R
Fixler D
author_sort Ankri R
title A new method for cancer detection based on diffusion reflection measurements of targeted gold nanorods
title_short A new method for cancer detection based on diffusion reflection measurements of targeted gold nanorods
title_full A new method for cancer detection based on diffusion reflection measurements of targeted gold nanorods
title_fullStr A new method for cancer detection based on diffusion reflection measurements of targeted gold nanorods
title_full_unstemmed A new method for cancer detection based on diffusion reflection measurements of targeted gold nanorods
title_sort new method for cancer detection based on diffusion reflection measurements of targeted gold nanorods
publisher Dove Medical Press
publishDate 2012
url https://doaj.org/article/374b24f94d494b588b8c310ec4aed851
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