Multi-factors including Inflammatory/Immune, Hormones, Tumor-related Proteins and Nutrition associated with Chronic Prostatitis NIH IIIa+b and IV based on FAMHES project
Abstract Chronic prostatitis (CP) is a complex disease. Fragmentary evidence suggests that factors such as infection and autoimmunity might be associated with CP. To further elucidate potential risk factors, the current study utilized the Fangchenggang Area Male Health and Examination Survey (FAMHES...
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2017
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oai:doaj.org-article:374bd6ecdbdd46afb287691d6f5e48fc2021-12-02T15:06:05ZMulti-factors including Inflammatory/Immune, Hormones, Tumor-related Proteins and Nutrition associated with Chronic Prostatitis NIH IIIa+b and IV based on FAMHES project10.1038/s41598-017-09751-82045-2322https://doaj.org/article/374bd6ecdbdd46afb287691d6f5e48fc2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09751-8https://doaj.org/toc/2045-2322Abstract Chronic prostatitis (CP) is a complex disease. Fragmentary evidence suggests that factors such as infection and autoimmunity might be associated with CP. To further elucidate potential risk factors, the current study utilized the Fangchenggang Area Male Health and Examination Survey (FAMHES) project; where 22 inflammatory/immune markers, hormone markers, tumor-related proteins, and nutrition-related variables were investigated. We also performed baseline, regression, discriminant, and receiver operating characteristic (ROC) analyses. According to NIH-Chronic Prostatitis Symptom Index (NIH-CPSI), participants were divided into chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS, pain ≥ 4; divided into IIIa and IIIb sub-groups) and non-CPPS (pain = 0; divided into IV and normal sub-groups). Analyses revealed osteocalcin as a consistent protective factor for CP/CPPS, NIH-IIIb, and NIH-IV prostatitis. Further discriminant analysis revealed that ferritin (p = 0.002) and prostate-specific antigen (PSA) (p = 0.010) were significantly associated with NIH-IIIa and NIH-IV prostatitis, respectively. Moreover, ROC analysis suggested that ferritin was the most valuable independent predictor of NIH-IIIa prostatitis (AUC = 0.639, 95% CI = 0.534–0.745, p = 0.006). Together, our study revealed inflammatory/immune markers [immunoglobulin E, Complement (C3, C4), C-reactive protein, anti-streptolysin, and rheumatoid factors], hormone markers (osteocalcin, testosterone, follicle-stimulating hormone, and insulin), tumor-related proteins (carcinoembryonic and PSA), and a nutrition-related variable (ferritin) were significantly associated with CP or one of its subtypes.Yang ChenJie LiYanling HuHaiying ZhangXiaobo YangYonghua JiangZiting YaoYinchun ChenYong GaoAihua TanMing LiaoZhen LuChunlei WuXiaoyin XianSuchun WeiZhifu ZhangWei ChenGong-Hong WeiQiuyan WangZengnan MoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017) |
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Medicine R Science Q Yang Chen Jie Li Yanling Hu Haiying Zhang Xiaobo Yang Yonghua Jiang Ziting Yao Yinchun Chen Yong Gao Aihua Tan Ming Liao Zhen Lu Chunlei Wu Xiaoyin Xian Suchun Wei Zhifu Zhang Wei Chen Gong-Hong Wei Qiuyan Wang Zengnan Mo Multi-factors including Inflammatory/Immune, Hormones, Tumor-related Proteins and Nutrition associated with Chronic Prostatitis NIH IIIa+b and IV based on FAMHES project |
| description |
Abstract Chronic prostatitis (CP) is a complex disease. Fragmentary evidence suggests that factors such as infection and autoimmunity might be associated with CP. To further elucidate potential risk factors, the current study utilized the Fangchenggang Area Male Health and Examination Survey (FAMHES) project; where 22 inflammatory/immune markers, hormone markers, tumor-related proteins, and nutrition-related variables were investigated. We also performed baseline, regression, discriminant, and receiver operating characteristic (ROC) analyses. According to NIH-Chronic Prostatitis Symptom Index (NIH-CPSI), participants were divided into chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS, pain ≥ 4; divided into IIIa and IIIb sub-groups) and non-CPPS (pain = 0; divided into IV and normal sub-groups). Analyses revealed osteocalcin as a consistent protective factor for CP/CPPS, NIH-IIIb, and NIH-IV prostatitis. Further discriminant analysis revealed that ferritin (p = 0.002) and prostate-specific antigen (PSA) (p = 0.010) were significantly associated with NIH-IIIa and NIH-IV prostatitis, respectively. Moreover, ROC analysis suggested that ferritin was the most valuable independent predictor of NIH-IIIa prostatitis (AUC = 0.639, 95% CI = 0.534–0.745, p = 0.006). Together, our study revealed inflammatory/immune markers [immunoglobulin E, Complement (C3, C4), C-reactive protein, anti-streptolysin, and rheumatoid factors], hormone markers (osteocalcin, testosterone, follicle-stimulating hormone, and insulin), tumor-related proteins (carcinoembryonic and PSA), and a nutrition-related variable (ferritin) were significantly associated with CP or one of its subtypes. |
| format |
article |
| author |
Yang Chen Jie Li Yanling Hu Haiying Zhang Xiaobo Yang Yonghua Jiang Ziting Yao Yinchun Chen Yong Gao Aihua Tan Ming Liao Zhen Lu Chunlei Wu Xiaoyin Xian Suchun Wei Zhifu Zhang Wei Chen Gong-Hong Wei Qiuyan Wang Zengnan Mo |
| author_facet |
Yang Chen Jie Li Yanling Hu Haiying Zhang Xiaobo Yang Yonghua Jiang Ziting Yao Yinchun Chen Yong Gao Aihua Tan Ming Liao Zhen Lu Chunlei Wu Xiaoyin Xian Suchun Wei Zhifu Zhang Wei Chen Gong-Hong Wei Qiuyan Wang Zengnan Mo |
| author_sort |
Yang Chen |
| title |
Multi-factors including Inflammatory/Immune, Hormones, Tumor-related Proteins and Nutrition associated with Chronic Prostatitis NIH IIIa+b and IV based on FAMHES project |
| title_short |
Multi-factors including Inflammatory/Immune, Hormones, Tumor-related Proteins and Nutrition associated with Chronic Prostatitis NIH IIIa+b and IV based on FAMHES project |
| title_full |
Multi-factors including Inflammatory/Immune, Hormones, Tumor-related Proteins and Nutrition associated with Chronic Prostatitis NIH IIIa+b and IV based on FAMHES project |
| title_fullStr |
Multi-factors including Inflammatory/Immune, Hormones, Tumor-related Proteins and Nutrition associated with Chronic Prostatitis NIH IIIa+b and IV based on FAMHES project |
| title_full_unstemmed |
Multi-factors including Inflammatory/Immune, Hormones, Tumor-related Proteins and Nutrition associated with Chronic Prostatitis NIH IIIa+b and IV based on FAMHES project |
| title_sort |
multi-factors including inflammatory/immune, hormones, tumor-related proteins and nutrition associated with chronic prostatitis nih iiia+b and iv based on famhes project |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/374bd6ecdbdd46afb287691d6f5e48fc |
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