Effect of Copper, Zinc, and Selenium on the Migration of Bovine Neutrophils

Neutrophils represent the first line of mammary gland defense against invading pathogens by transmigration across the mammary epithelial cell barrier. The effect of trace elements on the migration of bovine neutrophils is not clear. In this study, we investigated the effect of copper (Cu; 0.5, 1.0 a...

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Autores principales:	Hai Wang, Guanxin Lv, Shuai Lian, Jianfa Wang, Rui Wu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	dairy cow neutrophil migration trace elements Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/374c40f9cd5c435985de683b7a0d62c6
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spelling	oai:doaj.org-article:374c40f9cd5c435985de683b7a0d62c62021-11-25T19:12:09ZEffect of Copper, Zinc, and Selenium on the Migration of Bovine Neutrophils10.3390/vetsci81102812306-7381https://doaj.org/article/374c40f9cd5c435985de683b7a0d62c62021-11-01T00:00:00Zhttps://www.mdpi.com/2306-7381/8/11/281https://doaj.org/toc/2306-7381Neutrophils represent the first line of mammary gland defense against invading pathogens by transmigration across the mammary epithelial cell barrier. The effect of trace elements on the migration of bovine neutrophils is not clear. In this study, we investigated the effect of copper (Cu; 0.5, 1.0 and 1.5 mg/L), zinc (Zn; 1.0, 5.0 and 10 mg/L) and selenium (Se; 0.1, 1.0 and 2.0 mg/L) on the migration of bovine neutrophils by using a Transwell assay. The results showed that Cu, Zn and Se promoted the number of neutrophils in the trans-mammary epithelium. With the increased concentration of Cu at 1.5 mg/L, the number of neutrophils in the trans-mammary epithelium was increased significantly (<i>p</i> < 0.05). Zn (5.0 mg/L) and Se (0.1 mg/L) increased the migrated number of neutrophils (<i>p</i> < 0.01) to an extremely significant degree. These findings provided a theoretical and experimental basis for mammary gland immunity in dairy cows. Thus, we suggest that adding moderate amounts of different trace elements can improve the immune function of dairy cows.Hai WangGuanxin LvShuai LianJianfa WangRui WuMDPI AGarticledairy cowneutrophilmigrationtrace elementsVeterinary medicineSF600-1100ENVeterinary Sciences, Vol 8, Iss 281, p 281 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dairy cow neutrophil migration trace elements Veterinary medicine SF600-1100
spellingShingle	dairy cow neutrophil migration trace elements Veterinary medicine SF600-1100 Hai Wang Guanxin Lv Shuai Lian Jianfa Wang Rui Wu Effect of Copper, Zinc, and Selenium on the Migration of Bovine Neutrophils
description	Neutrophils represent the first line of mammary gland defense against invading pathogens by transmigration across the mammary epithelial cell barrier. The effect of trace elements on the migration of bovine neutrophils is not clear. In this study, we investigated the effect of copper (Cu; 0.5, 1.0 and 1.5 mg/L), zinc (Zn; 1.0, 5.0 and 10 mg/L) and selenium (Se; 0.1, 1.0 and 2.0 mg/L) on the migration of bovine neutrophils by using a Transwell assay. The results showed that Cu, Zn and Se promoted the number of neutrophils in the trans-mammary epithelium. With the increased concentration of Cu at 1.5 mg/L, the number of neutrophils in the trans-mammary epithelium was increased significantly (<i>p</i> < 0.05). Zn (5.0 mg/L) and Se (0.1 mg/L) increased the migrated number of neutrophils (<i>p</i> < 0.01) to an extremely significant degree. These findings provided a theoretical and experimental basis for mammary gland immunity in dairy cows. Thus, we suggest that adding moderate amounts of different trace elements can improve the immune function of dairy cows.
format	article
author	Hai Wang Guanxin Lv Shuai Lian Jianfa Wang Rui Wu
author_facet	Hai Wang Guanxin Lv Shuai Lian Jianfa Wang Rui Wu
author_sort	Hai Wang
title	Effect of Copper, Zinc, and Selenium on the Migration of Bovine Neutrophils
title_short	Effect of Copper, Zinc, and Selenium on the Migration of Bovine Neutrophils
title_full	Effect of Copper, Zinc, and Selenium on the Migration of Bovine Neutrophils
title_fullStr	Effect of Copper, Zinc, and Selenium on the Migration of Bovine Neutrophils
title_full_unstemmed	Effect of Copper, Zinc, and Selenium on the Migration of Bovine Neutrophils
title_sort	effect of copper, zinc, and selenium on the migration of bovine neutrophils
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/374c40f9cd5c435985de683b7a0d62c6
work_keys_str_mv	AT haiwang effectofcopperzincandseleniumonthemigrationofbovineneutrophils AT guanxinlv effectofcopperzincandseleniumonthemigrationofbovineneutrophils AT shuailian effectofcopperzincandseleniumonthemigrationofbovineneutrophils AT jianfawang effectofcopperzincandseleniumonthemigrationofbovineneutrophils AT ruiwu effectofcopperzincandseleniumonthemigrationofbovineneutrophils
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Effect of Copper, Zinc, and Selenium on the Migration of Bovine Neutrophils

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