Planarians as an In Vivo Experimental Model for the Study of New Radioprotective Substances

Ionising radiation causes the death of the most actively dividing cells, thus leading to depletion of the stem cell pool. Planarians are invertebrate flatworms that are unique in that their stem cells, called neoblasts, constantly replace old, damaged, or dying cells. Amenability to efficient RNAi t...

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Autores principales:	Artem M. Ermakov, Kristina A. Kamenskikh, Olga N. Ermakova, Artem S. Blagodatsky, Anton L. Popov, Vladimir K. Ivanov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	planarians model animal irradiation regeneration radioprotection Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/374cd3698525474ea4aa5c4390548866
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spelling	oai:doaj.org-article:374cd3698525474ea4aa5c43905488662021-11-25T16:27:57ZPlanarians as an In Vivo Experimental Model for the Study of New Radioprotective Substances10.3390/antiox101117632076-3921https://doaj.org/article/374cd3698525474ea4aa5c43905488662021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1763https://doaj.org/toc/2076-3921Ionising radiation causes the death of the most actively dividing cells, thus leading to depletion of the stem cell pool. Planarians are invertebrate flatworms that are unique in that their stem cells, called neoblasts, constantly replace old, damaged, or dying cells. Amenability to efficient RNAi treatments, the rapid development of clear phenotypes, and sensitivity to ionising radiation, combined with new genomic technologies, make planarians an outstanding tool for the discovery of potential radioprotective agents. In this work, using the well-known antioxidant N-acetylcysteine, planarians are, for the first time, shown to be an excellent model system for the fast and effective screening of novel radioprotective and radio-sensitising substances. In addition, a panel of measurable parameters that can be used for the study of radioprotective effects on this model is suggested.Artem M. ErmakovKristina A. KamenskikhOlga N. ErmakovaArtem S. BlagodatskyAnton L. PopovVladimir K. IvanovMDPI AGarticleplanariansmodel animalirradiationregenerationradioprotectionTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1763, p 1763 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	planarians model animal irradiation regeneration radioprotection Therapeutics. Pharmacology RM1-950
spellingShingle	planarians model animal irradiation regeneration radioprotection Therapeutics. Pharmacology RM1-950 Artem M. Ermakov Kristina A. Kamenskikh Olga N. Ermakova Artem S. Blagodatsky Anton L. Popov Vladimir K. Ivanov Planarians as an In Vivo Experimental Model for the Study of New Radioprotective Substances
description	Ionising radiation causes the death of the most actively dividing cells, thus leading to depletion of the stem cell pool. Planarians are invertebrate flatworms that are unique in that their stem cells, called neoblasts, constantly replace old, damaged, or dying cells. Amenability to efficient RNAi treatments, the rapid development of clear phenotypes, and sensitivity to ionising radiation, combined with new genomic technologies, make planarians an outstanding tool for the discovery of potential radioprotective agents. In this work, using the well-known antioxidant N-acetylcysteine, planarians are, for the first time, shown to be an excellent model system for the fast and effective screening of novel radioprotective and radio-sensitising substances. In addition, a panel of measurable parameters that can be used for the study of radioprotective effects on this model is suggested.
format	article
author	Artem M. Ermakov Kristina A. Kamenskikh Olga N. Ermakova Artem S. Blagodatsky Anton L. Popov Vladimir K. Ivanov
author_facet	Artem M. Ermakov Kristina A. Kamenskikh Olga N. Ermakova Artem S. Blagodatsky Anton L. Popov Vladimir K. Ivanov
author_sort	Artem M. Ermakov
title	Planarians as an In Vivo Experimental Model for the Study of New Radioprotective Substances
title_short	Planarians as an In Vivo Experimental Model for the Study of New Radioprotective Substances
title_full	Planarians as an In Vivo Experimental Model for the Study of New Radioprotective Substances
title_fullStr	Planarians as an In Vivo Experimental Model for the Study of New Radioprotective Substances
title_full_unstemmed	Planarians as an In Vivo Experimental Model for the Study of New Radioprotective Substances
title_sort	planarians as an in vivo experimental model for the study of new radioprotective substances
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/374cd3698525474ea4aa5c4390548866
work_keys_str_mv	AT artemmermakov planariansasaninvivoexperimentalmodelforthestudyofnewradioprotectivesubstances AT kristinaakamenskikh planariansasaninvivoexperimentalmodelforthestudyofnewradioprotectivesubstances AT olganermakova planariansasaninvivoexperimentalmodelforthestudyofnewradioprotectivesubstances AT artemsblagodatsky planariansasaninvivoexperimentalmodelforthestudyofnewradioprotectivesubstances AT antonlpopov planariansasaninvivoexperimentalmodelforthestudyofnewradioprotectivesubstances AT vladimirkivanov planariansasaninvivoexperimentalmodelforthestudyofnewradioprotectivesubstances
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Planarians as an In Vivo Experimental Model for the Study of New Radioprotective Substances

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