Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.

Reduced basal ganglia function has been associated with fatigue in neurologic disorders, as well as in patients exposed to chronic immune stimulation. Patients with chronic fatigue syndrome (CFS) have been shown to exhibit symptoms suggestive of decreased basal ganglia function including psychomotor...

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Autores principales:	Andrew H Miller, James F Jones, Daniel F Drake, Hao Tian, Elizabeth R Unger, Giuseppe Pagnoni
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/374df5be80d84084ab5b6744534806b8
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spelling	oai:doaj.org-article:374df5be80d84084ab5b6744534806b82021-11-18T08:18:11ZDecreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.1932-620310.1371/journal.pone.0098156https://doaj.org/article/374df5be80d84084ab5b6744534806b82014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24858857/?tool=EBIhttps://doaj.org/toc/1932-6203Reduced basal ganglia function has been associated with fatigue in neurologic disorders, as well as in patients exposed to chronic immune stimulation. Patients with chronic fatigue syndrome (CFS) have been shown to exhibit symptoms suggestive of decreased basal ganglia function including psychomotor slowing, which in turn was correlated with fatigue. In addition, CFS patients have been found to exhibit increased markers of immune activation. In order to directly test the hypothesis of decreased basal ganglia function in CFS, we used functional magnetic resonance imaging to examine neural activation in the basal ganglia to a reward-processing (monetary gambling) task in a community sample of 59 male and female subjects, including 18 patients diagnosed with CFS according to 1994 CDC criteria and 41 non-fatigued healthy controls. For each subject, the average effect of winning vs. losing during the gambling task in regions of interest (ROI) corresponding to the caudate nucleus, putamen, and globus pallidus was extracted for group comparisons and correlational analyses. Compared to non-fatigued controls, patients with CFS exhibited significantly decreased activation in the right caudate (p = 0.01) and right globus pallidus (p = 0.02). Decreased activation in the right globus pallidus was significantly correlated with increased mental fatigue (r2 = 0.49, p = 0.001), general fatigue (r2 = 0.34, p = 0.01) and reduced activity (r2 = 0.29, p = 0.02) as measured by the Multidimensional Fatigue Inventory. No such relationships were found in control subjects. These data suggest that symptoms of fatigue in CFS subjects were associated with reduced responsivity of the basal ganglia, possibly involving the disruption of projections from the globus pallidus to thalamic and cortical networks.Andrew H MillerJames F JonesDaniel F DrakeHao TianElizabeth R UngerGiuseppe PagnoniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e98156 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrew H Miller James F Jones Daniel F Drake Hao Tian Elizabeth R Unger Giuseppe Pagnoni Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.
description	Reduced basal ganglia function has been associated with fatigue in neurologic disorders, as well as in patients exposed to chronic immune stimulation. Patients with chronic fatigue syndrome (CFS) have been shown to exhibit symptoms suggestive of decreased basal ganglia function including psychomotor slowing, which in turn was correlated with fatigue. In addition, CFS patients have been found to exhibit increased markers of immune activation. In order to directly test the hypothesis of decreased basal ganglia function in CFS, we used functional magnetic resonance imaging to examine neural activation in the basal ganglia to a reward-processing (monetary gambling) task in a community sample of 59 male and female subjects, including 18 patients diagnosed with CFS according to 1994 CDC criteria and 41 non-fatigued healthy controls. For each subject, the average effect of winning vs. losing during the gambling task in regions of interest (ROI) corresponding to the caudate nucleus, putamen, and globus pallidus was extracted for group comparisons and correlational analyses. Compared to non-fatigued controls, patients with CFS exhibited significantly decreased activation in the right caudate (p = 0.01) and right globus pallidus (p = 0.02). Decreased activation in the right globus pallidus was significantly correlated with increased mental fatigue (r2 = 0.49, p = 0.001), general fatigue (r2 = 0.34, p = 0.01) and reduced activity (r2 = 0.29, p = 0.02) as measured by the Multidimensional Fatigue Inventory. No such relationships were found in control subjects. These data suggest that symptoms of fatigue in CFS subjects were associated with reduced responsivity of the basal ganglia, possibly involving the disruption of projections from the globus pallidus to thalamic and cortical networks.
format	article
author	Andrew H Miller James F Jones Daniel F Drake Hao Tian Elizabeth R Unger Giuseppe Pagnoni
author_facet	Andrew H Miller James F Jones Daniel F Drake Hao Tian Elizabeth R Unger Giuseppe Pagnoni
author_sort	Andrew H Miller
title	Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.
title_short	Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.
title_full	Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.
title_fullStr	Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.
title_full_unstemmed	Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.
title_sort	decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/374df5be80d84084ab5b6744534806b8
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Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.

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