The serotype distribution of Streptococcus agalactiae (GBS) carriage isolates among pregnant women having risk factors for early-onset GBS disease: a comparative study with GBS causing invasive infections during the same period in Denmark

Abstract Background We describe the serotype distribution of Streptococcus agalactiae (GBS) carriage isolates from women in labor and among GBS isolates causing invasive infections during the same period to see if the distribution of carriage serotypes reflects the GBS serotypes causing invasive dis...

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Autores principales:	Hans-Christian Slotved, Jens Kjølseth Møller, Mohammad Rohi Khalil, Stine Yde Nielsen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Group B streptococci Streptococcus agalactiae EOGBS Pregnancy Carriage Antimicrobial susceptibility Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/374e15ef40484414b64f733f86df5b4e
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spelling	oai:doaj.org-article:374e15ef40484414b64f733f86df5b4e2021-11-08T11:18:22ZThe serotype distribution of Streptococcus agalactiae (GBS) carriage isolates among pregnant women having risk factors for early-onset GBS disease: a comparative study with GBS causing invasive infections during the same period in Denmark10.1186/s12879-021-06820-21471-2334https://doaj.org/article/374e15ef40484414b64f733f86df5b4e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06820-2https://doaj.org/toc/1471-2334Abstract Background We describe the serotype distribution of Streptococcus agalactiae (GBS) carriage isolates from women in labor and among GBS isolates causing invasive infections during the same period to see if the distribution of carriage serotypes reflects the GBS serotypes causing invasive diseases including early-onset disease (EOGBS). Methods Data on invasive isolates from 2019 including serotype, erythromycin and clindamycin susceptibility was retrieved from the Danish national reference laboratory, Statens Serum Institut. Carriage isolates were collected from women with risk factors for EOGBS enrolled at delivery at the maternity ward at a Danish University Hospital, first half of 2019. Results Among carriage isolates, the dominant serotype was IX (21 %) followed by serotype III (19 %). The resistance to erythromycin and clindamycin was 21 and 26 %, respectively. Among invasive GBS isolates, no case of EOGBS with serotype IX was detected but the distribution of serotypes were otherwise similar to the GBS carrier strains. The corresponding resistance to erythromycin and clindamycin was 23 and 15 %, respectively. Penicillin resistance was not detected among carriage nor invasive isolates. Conclusions The distribution of serotypes among carriage and invasive GBS reflects the assumption that EOGBS occur following transmission of GBS from mother to newborn, with the exception of serotype IX.Hans-Christian SlotvedJens Kjølseth MøllerMohammad Rohi KhalilStine Yde NielsenBMCarticleGroup B streptococciStreptococcus agalactiaeEOGBSPregnancyCarriageAntimicrobial susceptibilityInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Group B streptococci Streptococcus agalactiae EOGBS Pregnancy Carriage Antimicrobial susceptibility Infectious and parasitic diseases RC109-216
spellingShingle	Group B streptococci Streptococcus agalactiae EOGBS Pregnancy Carriage Antimicrobial susceptibility Infectious and parasitic diseases RC109-216 Hans-Christian Slotved Jens Kjølseth Møller Mohammad Rohi Khalil Stine Yde Nielsen The serotype distribution of Streptococcus agalactiae (GBS) carriage isolates among pregnant women having risk factors for early-onset GBS disease: a comparative study with GBS causing invasive infections during the same period in Denmark
description	Abstract Background We describe the serotype distribution of Streptococcus agalactiae (GBS) carriage isolates from women in labor and among GBS isolates causing invasive infections during the same period to see if the distribution of carriage serotypes reflects the GBS serotypes causing invasive diseases including early-onset disease (EOGBS). Methods Data on invasive isolates from 2019 including serotype, erythromycin and clindamycin susceptibility was retrieved from the Danish national reference laboratory, Statens Serum Institut. Carriage isolates were collected from women with risk factors for EOGBS enrolled at delivery at the maternity ward at a Danish University Hospital, first half of 2019. Results Among carriage isolates, the dominant serotype was IX (21 %) followed by serotype III (19 %). The resistance to erythromycin and clindamycin was 21 and 26 %, respectively. Among invasive GBS isolates, no case of EOGBS with serotype IX was detected but the distribution of serotypes were otherwise similar to the GBS carrier strains. The corresponding resistance to erythromycin and clindamycin was 23 and 15 %, respectively. Penicillin resistance was not detected among carriage nor invasive isolates. Conclusions The distribution of serotypes among carriage and invasive GBS reflects the assumption that EOGBS occur following transmission of GBS from mother to newborn, with the exception of serotype IX.
format	article
author	Hans-Christian Slotved Jens Kjølseth Møller Mohammad Rohi Khalil Stine Yde Nielsen
author_facet	Hans-Christian Slotved Jens Kjølseth Møller Mohammad Rohi Khalil Stine Yde Nielsen
author_sort	Hans-Christian Slotved
title	The serotype distribution of Streptococcus agalactiae (GBS) carriage isolates among pregnant women having risk factors for early-onset GBS disease: a comparative study with GBS causing invasive infections during the same period in Denmark
title_short	The serotype distribution of Streptococcus agalactiae (GBS) carriage isolates among pregnant women having risk factors for early-onset GBS disease: a comparative study with GBS causing invasive infections during the same period in Denmark
title_full	The serotype distribution of Streptococcus agalactiae (GBS) carriage isolates among pregnant women having risk factors for early-onset GBS disease: a comparative study with GBS causing invasive infections during the same period in Denmark
title_fullStr	The serotype distribution of Streptococcus agalactiae (GBS) carriage isolates among pregnant women having risk factors for early-onset GBS disease: a comparative study with GBS causing invasive infections during the same period in Denmark
title_full_unstemmed	The serotype distribution of Streptococcus agalactiae (GBS) carriage isolates among pregnant women having risk factors for early-onset GBS disease: a comparative study with GBS causing invasive infections during the same period in Denmark
title_sort	serotype distribution of streptococcus agalactiae (gbs) carriage isolates among pregnant women having risk factors for early-onset gbs disease: a comparative study with gbs causing invasive infections during the same period in denmark
publisher	BMC
publishDate	2021
url	https://doaj.org/article/374e15ef40484414b64f733f86df5b4e
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The serotype distribution of Streptococcus agalactiae (GBS) carriage isolates among pregnant women having risk factors for early-onset GBS disease: a comparative study with GBS causing invasive infections during the same period in Denmark

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