MHC matching improves engraftment of iPSC-derived neurons in non-human primates

Major histocompatibility complex (MHC) matching improves graft survival rates after organ transplantation. Here the authors show that in macaques, MHC-matched iPSC-derived neurons provide better engraftment in the brain, with a lower immune response and higher survival of the transplanted neurons.

Guardado en:

Detalles Bibliográficos
Autores principales:	Asuka Morizane, Tetsuhiro Kikuchi, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Hisashi Doi, Aya Mawatari, Matthew F. Glasser, Takashi Shiina, Hirohito Ishigaki, Yasushi Itoh, Keisuke Okita, Emi Yamasaki, Daisuke Doi, Hirotaka Onoe, Kazumasa Ogasawara, Shinya Yamanaka, Jun Takahashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/37518cb36fd0402692f5bdd69bd784da
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:37518cb36fd0402692f5bdd69bd784da
record_format	dspace
spelling	oai:doaj.org-article:37518cb36fd0402692f5bdd69bd784da2021-12-02T14:40:35ZMHC matching improves engraftment of iPSC-derived neurons in non-human primates10.1038/s41467-017-00926-52041-1723https://doaj.org/article/37518cb36fd0402692f5bdd69bd784da2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00926-5https://doaj.org/toc/2041-1723Major histocompatibility complex (MHC) matching improves graft survival rates after organ transplantation. Here the authors show that in macaques, MHC-matched iPSC-derived neurons provide better engraftment in the brain, with a lower immune response and higher survival of the transplanted neurons.Asuka MorizaneTetsuhiro KikuchiTakuya HayashiHiroshi MizumaSayuki TakaraHisashi DoiAya MawatariMatthew F. GlasserTakashi ShiinaHirohito IshigakiYasushi ItohKeisuke OkitaEmi YamasakiDaisuke DoiHirotaka OnoeKazumasa OgasawaraShinya YamanakaJun TakahashiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Asuka Morizane Tetsuhiro Kikuchi Takuya Hayashi Hiroshi Mizuma Sayuki Takara Hisashi Doi Aya Mawatari Matthew F. Glasser Takashi Shiina Hirohito Ishigaki Yasushi Itoh Keisuke Okita Emi Yamasaki Daisuke Doi Hirotaka Onoe Kazumasa Ogasawara Shinya Yamanaka Jun Takahashi MHC matching improves engraftment of iPSC-derived neurons in non-human primates
description	Major histocompatibility complex (MHC) matching improves graft survival rates after organ transplantation. Here the authors show that in macaques, MHC-matched iPSC-derived neurons provide better engraftment in the brain, with a lower immune response and higher survival of the transplanted neurons.
format	article
author	Asuka Morizane Tetsuhiro Kikuchi Takuya Hayashi Hiroshi Mizuma Sayuki Takara Hisashi Doi Aya Mawatari Matthew F. Glasser Takashi Shiina Hirohito Ishigaki Yasushi Itoh Keisuke Okita Emi Yamasaki Daisuke Doi Hirotaka Onoe Kazumasa Ogasawara Shinya Yamanaka Jun Takahashi
author_facet	Asuka Morizane Tetsuhiro Kikuchi Takuya Hayashi Hiroshi Mizuma Sayuki Takara Hisashi Doi Aya Mawatari Matthew F. Glasser Takashi Shiina Hirohito Ishigaki Yasushi Itoh Keisuke Okita Emi Yamasaki Daisuke Doi Hirotaka Onoe Kazumasa Ogasawara Shinya Yamanaka Jun Takahashi
author_sort	Asuka Morizane
title	MHC matching improves engraftment of iPSC-derived neurons in non-human primates
title_short	MHC matching improves engraftment of iPSC-derived neurons in non-human primates
title_full	MHC matching improves engraftment of iPSC-derived neurons in non-human primates
title_fullStr	MHC matching improves engraftment of iPSC-derived neurons in non-human primates
title_full_unstemmed	MHC matching improves engraftment of iPSC-derived neurons in non-human primates
title_sort	mhc matching improves engraftment of ipsc-derived neurons in non-human primates
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/37518cb36fd0402692f5bdd69bd784da
work_keys_str_mv	AT asukamorizane mhcmatchingimprovesengraftmentofipscderivedneuronsinnonhumanprimates AT tetsuhirokikuchi mhcmatchingimprovesengraftmentofipscderivedneuronsinnonhumanprimates AT takuyahayashi mhcmatchingimprovesengraftmentofipscderivedneuronsinnonhumanprimates AT hiroshimizuma mhcmatchingimprovesengraftmentofipscderivedneuronsinnonhumanprimates AT sayukitakara mhcmatchingimprovesengraftmentofipscderivedneuronsinnonhumanprimates AT hisashidoi mhcmatchingimprovesengraftmentofipscderivedneuronsinnonhumanprimates AT ayamawatari mhcmatchingimprovesengraftmentofipscderivedneuronsinnonhumanprimates AT matthewfglasser mhcmatchingimprovesengraftmentofipscderivedneuronsinnonhumanprimates AT takashishiina mhcmatchingimprovesengraftmentofipscderivedneuronsinnonhumanprimates AT hirohitoishigaki mhcmatchingimprovesengraftmentofipscderivedneuronsinnonhumanprimates AT yasushiitoh mhcmatchingimprovesengraftmentofipscderivedneuronsinnonhumanprimates AT keisukeokita mhcmatchingimprovesengraftmentofipscderivedneuronsinnonhumanprimates AT emiyamasaki mhcmatchingimprovesengraftmentofipscderivedneuronsinnonhumanprimates AT daisukedoi mhcmatchingimprovesengraftmentofipscderivedneuronsinnonhumanprimates AT hirotakaonoe mhcmatchingimprovesengraftmentofipscderivedneuronsinnonhumanprimates AT kazumasaogasawara mhcmatchingimprovesengraftmentofipscderivedneuronsinnonhumanprimates AT shinyayamanaka mhcmatchingimprovesengraftmentofipscderivedneuronsinnonhumanprimates AT juntakahashi mhcmatchingimprovesengraftmentofipscderivedneuronsinnonhumanprimates
_version_	1718390230176759808

MHC matching improves engraftment of iPSC-derived neurons in non-human primates

Ejemplares similares