Prognostic value of preoperative circulating tumor cells counts in patients with UICC stage I-IV colorectal cancer.

Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. There is an urgent need to identify prognostic markers for patients undergoing curative resection of CRC. The detection of circulating tumor cells in peripheral blood is a promising approach to identify high-risk patient...

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Autores principales:	Thaer S A Abdalla, Jan Meiners, Sabine Riethdorf, Alexandra König, Nathaniel Melling, Tobias Gorges, Karl-F Karstens, Jakob R Izbicki, Klaus Pantel, Matthias Reeh
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3753e902e9c2444483685a2181ca4f92
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spelling	oai:doaj.org-article:3753e902e9c2444483685a2181ca4f922021-12-02T20:10:49ZPrognostic value of preoperative circulating tumor cells counts in patients with UICC stage I-IV colorectal cancer.1932-620310.1371/journal.pone.0252897https://doaj.org/article/3753e902e9c2444483685a2181ca4f922021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252897https://doaj.org/toc/1932-6203Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. There is an urgent need to identify prognostic markers for patients undergoing curative resection of CRC. The detection of circulating tumor cells in peripheral blood is a promising approach to identify high-risk patients with disseminated disease in colorectal cancer. This study aims to evaluate the prognostic relevance of preoperative CTCs using the Cellsearch® system (CS) in patients, who underwent resection with curative intent of different stages (UICC I-IV) of colorectal cancer. Out of 91 Patients who underwent colorectal resection, 68 patients were included in this study. CTC analysis was performed in patients with CRC UICC stages I-IV immediately before surgery. Data were correlated with clinicopathological parameters and patient outcomes. One or more CTCs/7.5 mL were detected in 45.6% (31/68) of patients. CTCs were detected in all stages of the Union of International Cancer Control (UICC), in stage I (1/4, 25%), in stage II (4/12, 33.3%), in stage III (5/19, 26.3%) and in stage IV (21/33, 63.6%). The detection of ≥ 1 CTCs/ 7.5ml correlated to the presence of distant overt metastases (p = 0.014) as well as with shorter progression-free (p = 0.008) and overall survival (p = 0.008). Multivariate analyses showed that the detection of ≥ 1 CTCs/ 7.5ml is an independent prognostic indicator for overall survival (HR, 3.14; 95% CI, 1.18-8.32; p = 0.021). The detection of CTCs is an independent and strong prognostic factor in CRC, which might improve the identification of high-risk patients in future clinical trials.Thaer S A AbdallaJan MeinersSabine RiethdorfAlexandra KönigNathaniel MellingTobias GorgesKarl-F KarstensJakob R IzbickiKlaus PantelMatthias ReehPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252897 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thaer S A Abdalla Jan Meiners Sabine Riethdorf Alexandra König Nathaniel Melling Tobias Gorges Karl-F Karstens Jakob R Izbicki Klaus Pantel Matthias Reeh Prognostic value of preoperative circulating tumor cells counts in patients with UICC stage I-IV colorectal cancer.
description	Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. There is an urgent need to identify prognostic markers for patients undergoing curative resection of CRC. The detection of circulating tumor cells in peripheral blood is a promising approach to identify high-risk patients with disseminated disease in colorectal cancer. This study aims to evaluate the prognostic relevance of preoperative CTCs using the Cellsearch® system (CS) in patients, who underwent resection with curative intent of different stages (UICC I-IV) of colorectal cancer. Out of 91 Patients who underwent colorectal resection, 68 patients were included in this study. CTC analysis was performed in patients with CRC UICC stages I-IV immediately before surgery. Data were correlated with clinicopathological parameters and patient outcomes. One or more CTCs/7.5 mL were detected in 45.6% (31/68) of patients. CTCs were detected in all stages of the Union of International Cancer Control (UICC), in stage I (1/4, 25%), in stage II (4/12, 33.3%), in stage III (5/19, 26.3%) and in stage IV (21/33, 63.6%). The detection of ≥ 1 CTCs/ 7.5ml correlated to the presence of distant overt metastases (p = 0.014) as well as with shorter progression-free (p = 0.008) and overall survival (p = 0.008). Multivariate analyses showed that the detection of ≥ 1 CTCs/ 7.5ml is an independent prognostic indicator for overall survival (HR, 3.14; 95% CI, 1.18-8.32; p = 0.021). The detection of CTCs is an independent and strong prognostic factor in CRC, which might improve the identification of high-risk patients in future clinical trials.
format	article
author	Thaer S A Abdalla Jan Meiners Sabine Riethdorf Alexandra König Nathaniel Melling Tobias Gorges Karl-F Karstens Jakob R Izbicki Klaus Pantel Matthias Reeh
author_facet	Thaer S A Abdalla Jan Meiners Sabine Riethdorf Alexandra König Nathaniel Melling Tobias Gorges Karl-F Karstens Jakob R Izbicki Klaus Pantel Matthias Reeh
author_sort	Thaer S A Abdalla
title	Prognostic value of preoperative circulating tumor cells counts in patients with UICC stage I-IV colorectal cancer.
title_short	Prognostic value of preoperative circulating tumor cells counts in patients with UICC stage I-IV colorectal cancer.
title_full	Prognostic value of preoperative circulating tumor cells counts in patients with UICC stage I-IV colorectal cancer.
title_fullStr	Prognostic value of preoperative circulating tumor cells counts in patients with UICC stage I-IV colorectal cancer.
title_full_unstemmed	Prognostic value of preoperative circulating tumor cells counts in patients with UICC stage I-IV colorectal cancer.
title_sort	prognostic value of preoperative circulating tumor cells counts in patients with uicc stage i-iv colorectal cancer.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3753e902e9c2444483685a2181ca4f92
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Prognostic value of preoperative circulating tumor cells counts in patients with UICC stage I-IV colorectal cancer.

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