Bacterial Biofilm Destruction: A Focused Review On The Recent Use of Phage-Based Strategies With Other Antibiofilm Agents

Stephen Amankwah,1,2 Kedir Abdella,1 Tesfaye Kassa1 1School of Medical Laboratory Sciences, Institute of Health, Jimma University, Jimma, Ethiopia; 2Accra Medical Centre, Accra, GhanaCorrespondence: Tesfaye KassaSchool of Medical Laboratory Sciences, Institute of Health, Jimma University, P. O. Box...

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Autores principales:	Amankwah S, Abdella K, Kassa T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	biofilms extracellular polymeric substance phages phage-derived enzymes nanoparticles antimicrobial peptides Medical technology R855-855.5 Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/37570ef433cf4f5bb58ac595976d18dc
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spelling	oai:doaj.org-article:37570ef433cf4f5bb58ac595976d18dc2021-12-02T15:02:34ZBacterial Biofilm Destruction: A Focused Review On The Recent Use of Phage-Based Strategies With Other Antibiofilm Agents1177-8903https://doaj.org/article/37570ef433cf4f5bb58ac595976d18dc2021-09-01T00:00:00Zhttps://www.dovepress.com/bacterial-biofilm-destruction-a-focused-review-on-the-recent-use-of-ph-peer-reviewed-fulltext-article-NSAhttps://doaj.org/toc/1177-8903Stephen Amankwah,1,2 Kedir Abdella,1 Tesfaye Kassa1 1School of Medical Laboratory Sciences, Institute of Health, Jimma University, Jimma, Ethiopia; 2Accra Medical Centre, Accra, GhanaCorrespondence: Tesfaye KassaSchool of Medical Laboratory Sciences, Institute of Health, Jimma University, P. O. Box 788, Jimma, EthiopiaTel +251931057195Email ktes36@gmail.comAbstract: Biofilms are bacterial communities that live in association with biotic or abiotic surfaces and enclosed in an extracellular polymeric substance. Their formation on both biotic and abiotic surfaces, including human tissue and medical device surfaces, pose a major threat causing chronic infections. In addition, current antibiotics and antiseptic agents have shown limited ability to completely remove biofilms. In this review, the authors provide an overview on the formation of bacterial biofilms and its characteristics, burden and evolution with phages. Moreover, the most recent possible use of phages and phage-derived enzymes to combat bacteria in biofilm structures is elucidated. From the emerging results, it can be concluded that despite successful use of phages and phage-derived products in destroying biofilms, they are mostly not adequate to eradicate all bacterial cells. Nevertheless, a combined therapy with the use of phages and/or phage-derived products with other antimicrobial agents including antibiotics, nanoparticles, and antimicrobial peptides may be effective approaches to remove biofilms from medical device surfaces and to treat their associated infections in humans.Keywords: biofilms, extracellular polymeric substance, phages, phage-derived enzymes, nanoparticles, antimicrobial peptidesAmankwah SAbdella KKassa TDove Medical Pressarticlebiofilmsextracellular polymeric substancephagesphage-derived enzymesnanoparticlesantimicrobial peptidesMedical technologyR855-855.5Chemical technologyTP1-1185ENNanotechnology, Science and Applications, Vol Volume 14, Pp 161-177 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biofilms extracellular polymeric substance phages phage-derived enzymes nanoparticles antimicrobial peptides Medical technology R855-855.5 Chemical technology TP1-1185
spellingShingle	biofilms extracellular polymeric substance phages phage-derived enzymes nanoparticles antimicrobial peptides Medical technology R855-855.5 Chemical technology TP1-1185 Amankwah S Abdella K Kassa T Bacterial Biofilm Destruction: A Focused Review On The Recent Use of Phage-Based Strategies With Other Antibiofilm Agents
description	Stephen Amankwah,1,2 Kedir Abdella,1 Tesfaye Kassa1 1School of Medical Laboratory Sciences, Institute of Health, Jimma University, Jimma, Ethiopia; 2Accra Medical Centre, Accra, GhanaCorrespondence: Tesfaye KassaSchool of Medical Laboratory Sciences, Institute of Health, Jimma University, P. O. Box 788, Jimma, EthiopiaTel +251931057195Email ktes36@gmail.comAbstract: Biofilms are bacterial communities that live in association with biotic or abiotic surfaces and enclosed in an extracellular polymeric substance. Their formation on both biotic and abiotic surfaces, including human tissue and medical device surfaces, pose a major threat causing chronic infections. In addition, current antibiotics and antiseptic agents have shown limited ability to completely remove biofilms. In this review, the authors provide an overview on the formation of bacterial biofilms and its characteristics, burden and evolution with phages. Moreover, the most recent possible use of phages and phage-derived enzymes to combat bacteria in biofilm structures is elucidated. From the emerging results, it can be concluded that despite successful use of phages and phage-derived products in destroying biofilms, they are mostly not adequate to eradicate all bacterial cells. Nevertheless, a combined therapy with the use of phages and/or phage-derived products with other antimicrobial agents including antibiotics, nanoparticles, and antimicrobial peptides may be effective approaches to remove biofilms from medical device surfaces and to treat their associated infections in humans.Keywords: biofilms, extracellular polymeric substance, phages, phage-derived enzymes, nanoparticles, antimicrobial peptides
format	article
author	Amankwah S Abdella K Kassa T
author_facet	Amankwah S Abdella K Kassa T
author_sort	Amankwah S
title	Bacterial Biofilm Destruction: A Focused Review On The Recent Use of Phage-Based Strategies With Other Antibiofilm Agents
title_short	Bacterial Biofilm Destruction: A Focused Review On The Recent Use of Phage-Based Strategies With Other Antibiofilm Agents
title_full	Bacterial Biofilm Destruction: A Focused Review On The Recent Use of Phage-Based Strategies With Other Antibiofilm Agents
title_fullStr	Bacterial Biofilm Destruction: A Focused Review On The Recent Use of Phage-Based Strategies With Other Antibiofilm Agents
title_full_unstemmed	Bacterial Biofilm Destruction: A Focused Review On The Recent Use of Phage-Based Strategies With Other Antibiofilm Agents
title_sort	bacterial biofilm destruction: a focused review on the recent use of phage-based strategies with other antibiofilm agents
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/37570ef433cf4f5bb58ac595976d18dc
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Bacterial Biofilm Destruction: A Focused Review On The Recent Use of Phage-Based Strategies With Other Antibiofilm Agents

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