Pretreatment prognostic nutritional index as a prognostic marker in head and neck cancer: a systematic review and meta-analysis

Abstract The predictive value of the pretreatment prognostic nutritional index (PNI) for head and neck cancer (HNC) remains controversial. We conducted a meta-analysis to assess the predictive value of PNI in HNC patients. A systematic search through internet databases including PubMed, Embase, and...

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Autores principales:	Chih-Wei Luan, Yao-Te Tsai, Hsin-Yi Yang, Kuan-Yin Chen, Po-Hsien Chen, Hsin-Hsu Chou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/375a562e126d4f858f197e0f01d3828e
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spelling	oai:doaj.org-article:375a562e126d4f858f197e0f01d3828e2021-12-02T19:02:33ZPretreatment prognostic nutritional index as a prognostic marker in head and neck cancer: a systematic review and meta-analysis10.1038/s41598-021-96598-92045-2322https://doaj.org/article/375a562e126d4f858f197e0f01d3828e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96598-9https://doaj.org/toc/2045-2322Abstract The predictive value of the pretreatment prognostic nutritional index (PNI) for head and neck cancer (HNC) remains controversial. We conducted a meta-analysis to assess the predictive value of PNI in HNC patients. A systematic search through internet databases including PubMed, Embase, and Cochrane Library for qualified studies estimating the association of PNI with HNC patient survival was performed. Overall survival (OS), progression-free survival (PFS), disease-specific survival (DSS), disease-free survival (DFS) and distant metastasis-free survival (DMFS) data were collected and evaluated. A random-effects model was used to calculate the pooled hazard ratios (pHRs) and corresponding 95% confidence intervals (CIs). A total of 7815 HNC patients from 14 eligible studies were involved. Pooled analysis showed that low pretreatment PNI was correlated with poor OS (pHR: 1.93, 95% CI 1.62–2.30, p < 0.001), PFS (pHR: 1.51, 95% CI 1.19–1.92, p = 0.008), DSS (pHR: 1.98, 95% CI 1.12–3.50, p < 0.001), DFS (pHR: 2.20, 95% CI 1.66–2.91, p < 0.001) and DMFS (pHR: 2.04, 95% CI 1.74–2.38, p < 0.001). Furthermore, low pretreatment PNI was correlated with poor OS despite variations in the cancer site, sample size, PNI cut-off value, analysis method (multivariate analysis or univariate analysis) and treatment modality in subgroup analysis. Elevated pretreatment PNI is correlated with a superior prognosis in HNC patients and could be used as a biomarker in clinical practice for prognosis prediction and treatment stratification.Chih-Wei LuanYao-Te TsaiHsin-Yi YangKuan-Yin ChenPo-Hsien ChenHsin-Hsu ChouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chih-Wei Luan Yao-Te Tsai Hsin-Yi Yang Kuan-Yin Chen Po-Hsien Chen Hsin-Hsu Chou Pretreatment prognostic nutritional index as a prognostic marker in head and neck cancer: a systematic review and meta-analysis
description	Abstract The predictive value of the pretreatment prognostic nutritional index (PNI) for head and neck cancer (HNC) remains controversial. We conducted a meta-analysis to assess the predictive value of PNI in HNC patients. A systematic search through internet databases including PubMed, Embase, and Cochrane Library for qualified studies estimating the association of PNI with HNC patient survival was performed. Overall survival (OS), progression-free survival (PFS), disease-specific survival (DSS), disease-free survival (DFS) and distant metastasis-free survival (DMFS) data were collected and evaluated. A random-effects model was used to calculate the pooled hazard ratios (pHRs) and corresponding 95% confidence intervals (CIs). A total of 7815 HNC patients from 14 eligible studies were involved. Pooled analysis showed that low pretreatment PNI was correlated with poor OS (pHR: 1.93, 95% CI 1.62–2.30, p < 0.001), PFS (pHR: 1.51, 95% CI 1.19–1.92, p = 0.008), DSS (pHR: 1.98, 95% CI 1.12–3.50, p < 0.001), DFS (pHR: 2.20, 95% CI 1.66–2.91, p < 0.001) and DMFS (pHR: 2.04, 95% CI 1.74–2.38, p < 0.001). Furthermore, low pretreatment PNI was correlated with poor OS despite variations in the cancer site, sample size, PNI cut-off value, analysis method (multivariate analysis or univariate analysis) and treatment modality in subgroup analysis. Elevated pretreatment PNI is correlated with a superior prognosis in HNC patients and could be used as a biomarker in clinical practice for prognosis prediction and treatment stratification.
format	article
author	Chih-Wei Luan Yao-Te Tsai Hsin-Yi Yang Kuan-Yin Chen Po-Hsien Chen Hsin-Hsu Chou
author_facet	Chih-Wei Luan Yao-Te Tsai Hsin-Yi Yang Kuan-Yin Chen Po-Hsien Chen Hsin-Hsu Chou
author_sort	Chih-Wei Luan
title	Pretreatment prognostic nutritional index as a prognostic marker in head and neck cancer: a systematic review and meta-analysis
title_short	Pretreatment prognostic nutritional index as a prognostic marker in head and neck cancer: a systematic review and meta-analysis
title_full	Pretreatment prognostic nutritional index as a prognostic marker in head and neck cancer: a systematic review and meta-analysis
title_fullStr	Pretreatment prognostic nutritional index as a prognostic marker in head and neck cancer: a systematic review and meta-analysis
title_full_unstemmed	Pretreatment prognostic nutritional index as a prognostic marker in head and neck cancer: a systematic review and meta-analysis
title_sort	pretreatment prognostic nutritional index as a prognostic marker in head and neck cancer: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/375a562e126d4f858f197e0f01d3828e
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Pretreatment prognostic nutritional index as a prognostic marker in head and neck cancer: a systematic review and meta-analysis

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