Estimating the no-observed-adverse-effect-level (NOAEL) of hormetic dose-response relationships in meta-data evaluations

The number of studies reporting hormetic responses is rapidly increasing, and quantitative evaluations are needed to improve the understanding of hormetic dose responses. However, there is no standardized methodology to estimate the no-observed-adverse-effect-level (NOAEL) of hormetic dose-response...

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Autores principales:	Evgenios Agathokleous, Michael N Moore, Edward J Calabrese
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Contaminant effect Exposure-response relationship Hormesis Low-dose biological effects Organismal response Oxidative stress Science Q
Acceso en línea:	https://doaj.org/article/375f35e030944d609594e99e7cd6c0ed
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spelling	oai:doaj.org-article:375f35e030944d609594e99e7cd6c0ed2021-11-10T04:27:42ZEstimating the no-observed-adverse-effect-level (NOAEL) of hormetic dose-response relationships in meta-data evaluations2215-016110.1016/j.mex.2021.101568https://doaj.org/article/375f35e030944d609594e99e7cd6c0ed2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2215016121003587https://doaj.org/toc/2215-0161The number of studies reporting hormetic responses is rapidly increasing, and quantitative evaluations are needed to improve the understanding of hormetic dose responses. However, there is no standardized methodology to estimate the no-observed-adverse-effect-level (NOAEL) of hormetic dose-response relationships developed using data mined from the published literature. Here, we propose a protocol that can be followed to estimate NOAEL, a process that is illustrated using a specific example. This protocol can be used for maintaining a mutual language (since NOAEL can be defined in different ways), permitting comparisons among different studies, and facilitating cumulative science.Evgenios AgathokleousMichael N MooreEdward J CalabreseElsevierarticleContaminant effectExposure-response relationshipHormesisLow-dose biological effectsOrganismal responseOxidative stressScienceQENMethodsX, Vol 8, Iss , Pp 101568- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Contaminant effect Exposure-response relationship Hormesis Low-dose biological effects Organismal response Oxidative stress Science Q
spellingShingle	Contaminant effect Exposure-response relationship Hormesis Low-dose biological effects Organismal response Oxidative stress Science Q Evgenios Agathokleous Michael N Moore Edward J Calabrese Estimating the no-observed-adverse-effect-level (NOAEL) of hormetic dose-response relationships in meta-data evaluations
description	The number of studies reporting hormetic responses is rapidly increasing, and quantitative evaluations are needed to improve the understanding of hormetic dose responses. However, there is no standardized methodology to estimate the no-observed-adverse-effect-level (NOAEL) of hormetic dose-response relationships developed using data mined from the published literature. Here, we propose a protocol that can be followed to estimate NOAEL, a process that is illustrated using a specific example. This protocol can be used for maintaining a mutual language (since NOAEL can be defined in different ways), permitting comparisons among different studies, and facilitating cumulative science.
format	article
author	Evgenios Agathokleous Michael N Moore Edward J Calabrese
author_facet	Evgenios Agathokleous Michael N Moore Edward J Calabrese
author_sort	Evgenios Agathokleous
title	Estimating the no-observed-adverse-effect-level (NOAEL) of hormetic dose-response relationships in meta-data evaluations
title_short	Estimating the no-observed-adverse-effect-level (NOAEL) of hormetic dose-response relationships in meta-data evaluations
title_full	Estimating the no-observed-adverse-effect-level (NOAEL) of hormetic dose-response relationships in meta-data evaluations
title_fullStr	Estimating the no-observed-adverse-effect-level (NOAEL) of hormetic dose-response relationships in meta-data evaluations
title_full_unstemmed	Estimating the no-observed-adverse-effect-level (NOAEL) of hormetic dose-response relationships in meta-data evaluations
title_sort	estimating the no-observed-adverse-effect-level (noael) of hormetic dose-response relationships in meta-data evaluations
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/375f35e030944d609594e99e7cd6c0ed
work_keys_str_mv	AT evgeniosagathokleous estimatingthenoobservedadverseeffectlevelnoaelofhormeticdoseresponserelationshipsinmetadataevaluations AT michaelnmoore estimatingthenoobservedadverseeffectlevelnoaelofhormeticdoseresponserelationshipsinmetadataevaluations AT edwardjcalabrese estimatingthenoobservedadverseeffectlevelnoaelofhormeticdoseresponserelationshipsinmetadataevaluations
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Estimating the no-observed-adverse-effect-level (NOAEL) of hormetic dose-response relationships in meta-data evaluations

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