Thermoregulatory role of ghrelin in the induction of torpor under a restricted feeding condition

Abstract Ghrelin, a circulating orexigenic hormone secreted from the stomach, stimulates appetite and food intake by activating the hypothalamic arcuate nucleus. Administration of exogenous ghrelin exerts anabolic effects, causing weight gain, increased adiposity, and decreased metabolism. Body temp...

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Autores principales:	Takahiro Sato, Kanae Oishi, Daisuke Koga, Takanori Ida, Yusuke Sakai, Kenji Kangawa, Masayasu Kojima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3760edb0716a4432af266d328de19dbe
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spelling	oai:doaj.org-article:3760edb0716a4432af266d328de19dbe2021-12-02T18:49:53ZThermoregulatory role of ghrelin in the induction of torpor under a restricted feeding condition10.1038/s41598-021-97440-y2045-2322https://doaj.org/article/3760edb0716a4432af266d328de19dbe2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97440-yhttps://doaj.org/toc/2045-2322Abstract Ghrelin, a circulating orexigenic hormone secreted from the stomach, stimulates appetite and food intake by activating the hypothalamic arcuate nucleus. Administration of exogenous ghrelin exerts anabolic effects, causing weight gain, increased adiposity, and decreased metabolism. Body temperature (BT), which is determined by the balance of heat production and heat loss, must be strictly regulated to maintain proper cellular function and metabolism. However, the role of ghrelin in thermoregulation remains unclear. In this study, we found that ghrelin was essential for decreasing BT when mice are placed under calorie restriction. Elevated ghrelin concentrations induced by fasting correlated with significant decreases in BT, a hibernation-like state called torpor. Ghrelin-deficient (Ghrl −/− ) animals could not enter torpor. The BT of Ghrl −/− mice also remained high under restricted feeding, but the animals gradually entered precipitous hypothermia, indicating thermoregulatory impairment. These effects of ghrelin on thermoregulation were the result of suppression of sympathetic nervous system activity input to brown adipose tissue; in the absence of ghrelin, it was not possible to suppress uncoupling protein 1 (ucp1) expression and decrease BT in low-energy states. Together, these findings demonstrate that ghrelin is an essential circulating hormone involved in lowering BT.Takahiro SatoKanae OishiDaisuke KogaTakanori IdaYusuke SakaiKenji KangawaMasayasu KojimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takahiro Sato Kanae Oishi Daisuke Koga Takanori Ida Yusuke Sakai Kenji Kangawa Masayasu Kojima Thermoregulatory role of ghrelin in the induction of torpor under a restricted feeding condition
description	Abstract Ghrelin, a circulating orexigenic hormone secreted from the stomach, stimulates appetite and food intake by activating the hypothalamic arcuate nucleus. Administration of exogenous ghrelin exerts anabolic effects, causing weight gain, increased adiposity, and decreased metabolism. Body temperature (BT), which is determined by the balance of heat production and heat loss, must be strictly regulated to maintain proper cellular function and metabolism. However, the role of ghrelin in thermoregulation remains unclear. In this study, we found that ghrelin was essential for decreasing BT when mice are placed under calorie restriction. Elevated ghrelin concentrations induced by fasting correlated with significant decreases in BT, a hibernation-like state called torpor. Ghrelin-deficient (Ghrl −/− ) animals could not enter torpor. The BT of Ghrl −/− mice also remained high under restricted feeding, but the animals gradually entered precipitous hypothermia, indicating thermoregulatory impairment. These effects of ghrelin on thermoregulation were the result of suppression of sympathetic nervous system activity input to brown adipose tissue; in the absence of ghrelin, it was not possible to suppress uncoupling protein 1 (ucp1) expression and decrease BT in low-energy states. Together, these findings demonstrate that ghrelin is an essential circulating hormone involved in lowering BT.
format	article
author	Takahiro Sato Kanae Oishi Daisuke Koga Takanori Ida Yusuke Sakai Kenji Kangawa Masayasu Kojima
author_facet	Takahiro Sato Kanae Oishi Daisuke Koga Takanori Ida Yusuke Sakai Kenji Kangawa Masayasu Kojima
author_sort	Takahiro Sato
title	Thermoregulatory role of ghrelin in the induction of torpor under a restricted feeding condition
title_short	Thermoregulatory role of ghrelin in the induction of torpor under a restricted feeding condition
title_full	Thermoregulatory role of ghrelin in the induction of torpor under a restricted feeding condition
title_fullStr	Thermoregulatory role of ghrelin in the induction of torpor under a restricted feeding condition
title_full_unstemmed	Thermoregulatory role of ghrelin in the induction of torpor under a restricted feeding condition
title_sort	thermoregulatory role of ghrelin in the induction of torpor under a restricted feeding condition
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3760edb0716a4432af266d328de19dbe
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Thermoregulatory role of ghrelin in the induction of torpor under a restricted feeding condition

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