Cholecystokinin-like peptide mediates satiety by inhibiting sugar attraction.

Feeding is essential for animal survival and reproduction and is regulated by both internal states and external stimuli. However, little is known about how internal states influence the perception of external sensory cues that regulate feeding behavior. Here, we investigated the neuronal and molecul...

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Autores principales:	Di Guo, Yi-Jie Zhang, Su Zhang, Jian Li, Chao Guo, Yu-Feng Pan, Ning Zhang, Chen-Xi Liu, Ya-Long Jia, Chen-Yu Li, Jun-Yu Ma, Dick R Nässel, Cong-Fen Gao, Shun-Fan Wu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/3762f641ab4c4c8b9700415d14ae4e9e
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spelling	oai:doaj.org-article:3762f641ab4c4c8b9700415d14ae4e9e2021-12-02T20:02:52ZCholecystokinin-like peptide mediates satiety by inhibiting sugar attraction.1553-73901553-740410.1371/journal.pgen.1009724https://doaj.org/article/3762f641ab4c4c8b9700415d14ae4e9e2021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pgen.1009724https://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404Feeding is essential for animal survival and reproduction and is regulated by both internal states and external stimuli. However, little is known about how internal states influence the perception of external sensory cues that regulate feeding behavior. Here, we investigated the neuronal and molecular mechanisms behind nutritional state-mediated regulation of gustatory perception in control of feeding behavior in the brown planthopper and Drosophila. We found that feeding increases the expression of the cholecystokinin-like peptide, sulfakinin (SK), and the activity of a set of SK-expressing neurons. Starvation elevates the transcription of the sugar receptor Gr64f and SK negatively regulates the expression of Gr64f in both insects. Interestingly, we found that one of the two known SK receptors, CCKLR-17D3, is expressed by some of Gr64f-expressing neurons in the proboscis and proleg tarsi. Thus, we have identified SK as a neuropeptide signal in a neuronal circuitry that responds to food intake, and regulates feeding behavior by diminishing gustatory receptor gene expression and activity of sweet sensing GRNs. Our findings demonstrate one nutritional state-dependent pathway that modulates sweet perception and thereby feeding behavior, but our experiments cannot exclude further parallel pathways. Importantly, we show that the underlying mechanisms are conserved in the two distantly related insect species.Di GuoYi-Jie ZhangSu ZhangJian LiChao GuoYu-Feng PanNing ZhangChen-Xi LiuYa-Long JiaChen-Yu LiJun-Yu MaDick R NässelCong-Fen GaoShun-Fan WuPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 17, Iss 8, p e1009724 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Di Guo Yi-Jie Zhang Su Zhang Jian Li Chao Guo Yu-Feng Pan Ning Zhang Chen-Xi Liu Ya-Long Jia Chen-Yu Li Jun-Yu Ma Dick R Nässel Cong-Fen Gao Shun-Fan Wu Cholecystokinin-like peptide mediates satiety by inhibiting sugar attraction.
description	Feeding is essential for animal survival and reproduction and is regulated by both internal states and external stimuli. However, little is known about how internal states influence the perception of external sensory cues that regulate feeding behavior. Here, we investigated the neuronal and molecular mechanisms behind nutritional state-mediated regulation of gustatory perception in control of feeding behavior in the brown planthopper and Drosophila. We found that feeding increases the expression of the cholecystokinin-like peptide, sulfakinin (SK), and the activity of a set of SK-expressing neurons. Starvation elevates the transcription of the sugar receptor Gr64f and SK negatively regulates the expression of Gr64f in both insects. Interestingly, we found that one of the two known SK receptors, CCKLR-17D3, is expressed by some of Gr64f-expressing neurons in the proboscis and proleg tarsi. Thus, we have identified SK as a neuropeptide signal in a neuronal circuitry that responds to food intake, and regulates feeding behavior by diminishing gustatory receptor gene expression and activity of sweet sensing GRNs. Our findings demonstrate one nutritional state-dependent pathway that modulates sweet perception and thereby feeding behavior, but our experiments cannot exclude further parallel pathways. Importantly, we show that the underlying mechanisms are conserved in the two distantly related insect species.
format	article
author	Di Guo Yi-Jie Zhang Su Zhang Jian Li Chao Guo Yu-Feng Pan Ning Zhang Chen-Xi Liu Ya-Long Jia Chen-Yu Li Jun-Yu Ma Dick R Nässel Cong-Fen Gao Shun-Fan Wu
author_facet	Di Guo Yi-Jie Zhang Su Zhang Jian Li Chao Guo Yu-Feng Pan Ning Zhang Chen-Xi Liu Ya-Long Jia Chen-Yu Li Jun-Yu Ma Dick R Nässel Cong-Fen Gao Shun-Fan Wu
author_sort	Di Guo
title	Cholecystokinin-like peptide mediates satiety by inhibiting sugar attraction.
title_short	Cholecystokinin-like peptide mediates satiety by inhibiting sugar attraction.
title_full	Cholecystokinin-like peptide mediates satiety by inhibiting sugar attraction.
title_fullStr	Cholecystokinin-like peptide mediates satiety by inhibiting sugar attraction.
title_full_unstemmed	Cholecystokinin-like peptide mediates satiety by inhibiting sugar attraction.
title_sort	cholecystokinin-like peptide mediates satiety by inhibiting sugar attraction.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3762f641ab4c4c8b9700415d14ae4e9e
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Cholecystokinin-like peptide mediates satiety by inhibiting sugar attraction.

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