Vitamin K2 Prevents Lymphoma in Drosophila

Abstract Previous studies have established the anticancer effect of vitamin K2 (VK2). However, its effect on lymphoma induced by UBIAD1/heix mutation in Drosophila remains unknown. Therefore, we aimed to develop an in vivo model of lymphoma for the precise characterization of lymphoma phenotypes. We...

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Autores principales:	Maytham A. Dragh, Zhiliang Xu, Zainab S. Al-Allak, Ling Hong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/37694db5563b4352ac7b8305f14ffe26
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spelling	oai:doaj.org-article:37694db5563b4352ac7b8305f14ffe262021-12-02T15:05:44ZVitamin K2 Prevents Lymphoma in Drosophila10.1038/s41598-017-17270-92045-2322https://doaj.org/article/37694db5563b4352ac7b8305f14ffe262017-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-17270-9https://doaj.org/toc/2045-2322Abstract Previous studies have established the anticancer effect of vitamin K2 (VK2). However, its effect on lymphoma induced by UBIAD1/heix mutation in Drosophila remains unknown. Therefore, we aimed to develop an in vivo model of lymphoma for the precise characterization of lymphoma phenotypes. We also aimed to improve the understanding of the mechanisms that underlie the preventative effects of VK2 on lymphoma. Our results demonstrated that VK2 prevents lymphoma by acting as an electron carrier and by correcting the function and structure of mitochondria by inhibiting mitochondrial reactive oxygen species production mtROS. Our work identifies mitochondria as a key player in cancer therapy strategies.Maytham A. DraghZhiliang XuZainab S. Al-AllakLing HongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maytham A. Dragh Zhiliang Xu Zainab S. Al-Allak Ling Hong Vitamin K2 Prevents Lymphoma in Drosophila
description	Abstract Previous studies have established the anticancer effect of vitamin K2 (VK2). However, its effect on lymphoma induced by UBIAD1/heix mutation in Drosophila remains unknown. Therefore, we aimed to develop an in vivo model of lymphoma for the precise characterization of lymphoma phenotypes. We also aimed to improve the understanding of the mechanisms that underlie the preventative effects of VK2 on lymphoma. Our results demonstrated that VK2 prevents lymphoma by acting as an electron carrier and by correcting the function and structure of mitochondria by inhibiting mitochondrial reactive oxygen species production mtROS. Our work identifies mitochondria as a key player in cancer therapy strategies.
format	article
author	Maytham A. Dragh Zhiliang Xu Zainab S. Al-Allak Ling Hong
author_facet	Maytham A. Dragh Zhiliang Xu Zainab S. Al-Allak Ling Hong
author_sort	Maytham A. Dragh
title	Vitamin K2 Prevents Lymphoma in Drosophila
title_short	Vitamin K2 Prevents Lymphoma in Drosophila
title_full	Vitamin K2 Prevents Lymphoma in Drosophila
title_fullStr	Vitamin K2 Prevents Lymphoma in Drosophila
title_full_unstemmed	Vitamin K2 Prevents Lymphoma in Drosophila
title_sort	vitamin k2 prevents lymphoma in drosophila
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/37694db5563b4352ac7b8305f14ffe26
work_keys_str_mv	AT maythamadragh vitamink2preventslymphomaindrosophila AT zhiliangxu vitamink2preventslymphomaindrosophila AT zainabsalallak vitamink2preventslymphomaindrosophila AT linghong vitamink2preventslymphomaindrosophila
_version_	1718388696479170560

Vitamin K2 Prevents Lymphoma in Drosophila

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