EVALUATION OF IMMUNOLOGICAL SHIFTS IN ADULTS AFTER IMMUNIZATION AGAINST INFLUENZA WITH A SUBUNIT-BASED, ABSORBED MONOVALENT VACCINE STRAIN A/CALIFORNIA/7/2009/(H1N1)
Abstract. Seventy healthy volunteers were immunized with influenza subunit vaccine strain A/California/7/2009 / (H1N1), in order to test possible changes in auto-reactivity. It was shown that the vaccine is safe and immunogenic. In addition, it ...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | RU |
| Publicado: |
SPb RAACI
2014
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/3769d528eab84da19e2521e3aba5a64c |
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| Sumario: | Abstract. Seventy healthy volunteers were immunized with influenza subunit vaccine strain A/California/7/2009 / (H1N1), in order to test possible changes in auto-reactivity. It was shown that the vaccine is safe and immunogenic. In addition, it was revealed that a double injection of the vaccine was not accompanied by development of autoantibody response, both to tissue antigens (specifically, to lung tissue, or basic myelin protein), and to those against non-tissue antigens (native or denatured DNA). In some cases, application of the vaccine was accompanied by a significant reduction in levels of autoantibodies. It was also noted that injection of the vaccine is accompanied by a reduction in total IgE levels in patients with increased baseline IgE levels. Following double injection of the vaccine at a single dose of 0.5 ml, the frequencies of seroconversion was 71.4%, seroprotection levels were achieved in 59,2%, whereas seroconversion factor proved to be 4.92, thus meeting the CPMP criteria. (Med. Immunol., 2011, vol. 13, N 1, pp 35-40) |
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