EVALUATION OF IMMUNOLOGICAL SHIFTS IN ADULTS AFTER IMMUNIZATION AGAINST INFLUENZA WITH A SUBUNIT-BASED, ABSORBED MONOVALENT VACCINE STRAIN A/CALIFORNIA/7/2009/(H1N1)

Abstract. Seventy healthy volunteers were immunized with influenza subunit vaccine strain A/California/7/2009 / (H1N1), in order to test possible changes in auto-reactivity. It was shown that the vaccine is safe and immunogenic. In addition, it ...

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Autores principales:	M. P. Kostinov, O. A. Terkacheva, S. N. Girova, N. E. Jastrebova, A. P. Cherdantsev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	influenza vaccine autoantibodies safety immunogenicity autoreactivity Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/3769d528eab84da19e2521e3aba5a64c
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spelling	oai:doaj.org-article:3769d528eab84da19e2521e3aba5a64c2021-11-18T08:03:39ZEVALUATION OF IMMUNOLOGICAL SHIFTS IN ADULTS AFTER IMMUNIZATION AGAINST INFLUENZA WITH A SUBUNIT-BASED, ABSORBED MONOVALENT VACCINE STRAIN A/CALIFORNIA/7/2009/(H1N1)1563-06252313-741X10.15789/1563-0625-2011-1-35-40https://doaj.org/article/3769d528eab84da19e2521e3aba5a64c2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/284https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Seventy healthy volunteers were immunized with influenza subunit vaccine strain A/California/7/2009 / (H1N1), in order to test possible changes in auto-reactivity. It was shown that the vaccine is safe and immunogenic. In addition, it was revealed that a double injection of the vaccine was not accompanied by development of autoantibody response, both to tissue antigens (specifically, to lung tissue, or basic myelin protein), and to those against non-tissue antigens (native or denatured DNA). In some cases, application of the vaccine was accompanied by a significant reduction in levels of autoantibodies. It was also noted that injection of the vaccine is accompanied by a reduction in total IgE levels in patients with increased baseline IgE levels. Following double injection of the vaccine at a single dose of 0.5 ml, the frequencies of seroconversion was 71.4%, seroprotection levels were achieved in 59,2%, whereas seroconversion factor proved to be 4.92, thus meeting the CPMP criteria. (Med. Immunol., 2011, vol. 13, N 1, pp 35-40)M. P. KostinovO. A. TerkachevaS. N. GirovaN. E. JastrebovaA. P. CherdantsevSPb RAACIarticleinfluenza vaccineautoantibodiessafetyimmunogenicityautoreactivityImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 1, Pp 35-40 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	influenza vaccine autoantibodies safety immunogenicity autoreactivity Immunologic diseases. Allergy RC581-607
spellingShingle	influenza vaccine autoantibodies safety immunogenicity autoreactivity Immunologic diseases. Allergy RC581-607 M. P. Kostinov O. A. Terkacheva S. N. Girova N. E. Jastrebova A. P. Cherdantsev EVALUATION OF IMMUNOLOGICAL SHIFTS IN ADULTS AFTER IMMUNIZATION AGAINST INFLUENZA WITH A SUBUNIT-BASED, ABSORBED MONOVALENT VACCINE STRAIN A/CALIFORNIA/7/2009/(H1N1)
description	Abstract. Seventy healthy volunteers were immunized with influenza subunit vaccine strain A/California/7/2009 / (H1N1), in order to test possible changes in auto-reactivity. It was shown that the vaccine is safe and immunogenic. In addition, it was revealed that a double injection of the vaccine was not accompanied by development of autoantibody response, both to tissue antigens (specifically, to lung tissue, or basic myelin protein), and to those against non-tissue antigens (native or denatured DNA). In some cases, application of the vaccine was accompanied by a significant reduction in levels of autoantibodies. It was also noted that injection of the vaccine is accompanied by a reduction in total IgE levels in patients with increased baseline IgE levels. Following double injection of the vaccine at a single dose of 0.5 ml, the frequencies of seroconversion was 71.4%, seroprotection levels were achieved in 59,2%, whereas seroconversion factor proved to be 4.92, thus meeting the CPMP criteria. (Med. Immunol., 2011, vol. 13, N 1, pp 35-40)
format	article
author	M. P. Kostinov O. A. Terkacheva S. N. Girova N. E. Jastrebova A. P. Cherdantsev
author_facet	M. P. Kostinov O. A. Terkacheva S. N. Girova N. E. Jastrebova A. P. Cherdantsev
author_sort	M. P. Kostinov
title	EVALUATION OF IMMUNOLOGICAL SHIFTS IN ADULTS AFTER IMMUNIZATION AGAINST INFLUENZA WITH A SUBUNIT-BASED, ABSORBED MONOVALENT VACCINE STRAIN A/CALIFORNIA/7/2009/(H1N1)
title_short	EVALUATION OF IMMUNOLOGICAL SHIFTS IN ADULTS AFTER IMMUNIZATION AGAINST INFLUENZA WITH A SUBUNIT-BASED, ABSORBED MONOVALENT VACCINE STRAIN A/CALIFORNIA/7/2009/(H1N1)
title_full	EVALUATION OF IMMUNOLOGICAL SHIFTS IN ADULTS AFTER IMMUNIZATION AGAINST INFLUENZA WITH A SUBUNIT-BASED, ABSORBED MONOVALENT VACCINE STRAIN A/CALIFORNIA/7/2009/(H1N1)
title_fullStr	EVALUATION OF IMMUNOLOGICAL SHIFTS IN ADULTS AFTER IMMUNIZATION AGAINST INFLUENZA WITH A SUBUNIT-BASED, ABSORBED MONOVALENT VACCINE STRAIN A/CALIFORNIA/7/2009/(H1N1)
title_full_unstemmed	EVALUATION OF IMMUNOLOGICAL SHIFTS IN ADULTS AFTER IMMUNIZATION AGAINST INFLUENZA WITH A SUBUNIT-BASED, ABSORBED MONOVALENT VACCINE STRAIN A/CALIFORNIA/7/2009/(H1N1)
title_sort	evaluation of immunological shifts in adults after immunization against influenza with a subunit-based, absorbed monovalent vaccine strain a/california/7/2009/(h1n1)
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/3769d528eab84da19e2521e3aba5a64c
work_keys_str_mv	AT mpkostinov evaluationofimmunologicalshiftsinadultsafterimmunizationagainstinfluenzawithasubunitbasedabsorbedmonovalentvaccinestrainacalifornia72009h1n1 AT oaterkacheva evaluationofimmunologicalshiftsinadultsafterimmunizationagainstinfluenzawithasubunitbasedabsorbedmonovalentvaccinestrainacalifornia72009h1n1 AT sngirova evaluationofimmunologicalshiftsinadultsafterimmunizationagainstinfluenzawithasubunitbasedabsorbedmonovalentvaccinestrainacalifornia72009h1n1 AT nejastrebova evaluationofimmunologicalshiftsinadultsafterimmunizationagainstinfluenzawithasubunitbasedabsorbedmonovalentvaccinestrainacalifornia72009h1n1 AT apcherdantsev evaluationofimmunologicalshiftsinadultsafterimmunizationagainstinfluenzawithasubunitbasedabsorbedmonovalentvaccinestrainacalifornia72009h1n1
_version_	1718422535849115648

EVALUATION OF IMMUNOLOGICAL SHIFTS IN ADULTS AFTER IMMUNIZATION AGAINST INFLUENZA WITH A SUBUNIT-BASED, ABSORBED MONOVALENT VACCINE STRAIN A/CALIFORNIA/7/2009/(H1N1)

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