Cantharidin-encapsulated thermal-sensitive liposomes coated with gold nanoparticles for enhanced photothermal therapy on A431 cells

Sijia Wang, Jing Xin, Luwei Zhang, Yicheng Zhou, Cuiping Yao, Bing Wang, Jing Wang, Zhenxi Zhang Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Institute of Biomedical Analytical Technology and Instrumentation, Xi’an J...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang SJ, Xin J, Zhang LW, Zhou YC, Yao CP, Wang B, Wang J, Zhang ZX
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Gold nanoparticles Liposome，Cantharidin，Phtotothermal therapy Controlled release Heat shock response Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/376d2018cdcf4c54a5aa31dab777d21e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:376d2018cdcf4c54a5aa31dab777d21e
record_format	dspace
spelling	oai:doaj.org-article:376d2018cdcf4c54a5aa31dab777d21e2021-12-02T08:34:24ZCantharidin-encapsulated thermal-sensitive liposomes coated with gold nanoparticles for enhanced photothermal therapy on A431 cells1178-2013https://doaj.org/article/376d2018cdcf4c54a5aa31dab777d21e2018-04-01T00:00:00Zhttps://www.dovepress.com/cantharidin-encapsulated-thermal-sensitive-liposomes-coated-with-gold--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Sijia Wang, Jing Xin, Luwei Zhang, Yicheng Zhou, Cuiping Yao, Bing Wang, Jing Wang, Zhenxi Zhang Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Institute of Biomedical Analytical Technology and Instrumentation, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China Purpose: Plasmonic nanostructure-mediated photothermal therapy (PTT) is a promising alternative therapy for the treatment of skin cancer and other diseases. However, the insufficient efficiency of PTT at irradiation levels tolerable to tissues and the limited biodegradability of nanomaterials are still crucial challenges. In this study, a novel nanosystem for PTT based on liposome–nanoparticle assemblies (LNAs) was established.Materials and methods: Thermal-sensitive liposomes (TSLs) encapsulating cantharidin (CTD) were coated with gold nanoparticles (GNPs) and used in near-infrared (NIR) illumination-triggered PTT and thermally induced disruption on A431 cells.Results: The coated GNPs disintegrated into small particles of 5–6 nm after disruption of TSLs, allowing their clearance by the liver and kidneys. CTD encapsulated in the TSLs was released into cytoplasm after PTT. The released CTD increased the apoptosis of PTT-treated tumor cells by blocking the heat shock response (HSR) and inhibiting the expression of HSP70 and BAG3 inhibiting the expression of HSP70 and BAG3 with the synergistic enhancement of CTD, the new nanosystem CTD-encapsulated TSLs coated with GNPs (CTD-TSL@GNPs) had an efficient PTT effect using clinically acceptable irradiation power (200 mW/cm2) on A431 cells.Conclusion: The developed CTD-TSL@GNPs may be a promising PTT agent for clinical skin cancer therapy. Keywords: gold nanoparticles, liposome, cantharidin, photothermal therapy, heat shock response Wang SJXin JZhang LWZhou YCYao CPWang BWang JZhang ZXDove Medical PressarticleGold nanoparticlesLiposome，Cantharidin，Phtotothermal therapyControlled releaseHeat shock responseMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 2143-2160 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gold nanoparticles Liposome，Cantharidin，Phtotothermal therapy Controlled release Heat shock response Medicine (General) R5-920
spellingShingle	Gold nanoparticles Liposome，Cantharidin，Phtotothermal therapy Controlled release Heat shock response Medicine (General) R5-920 Wang SJ Xin J Zhang LW Zhou YC Yao CP Wang B Wang J Zhang ZX Cantharidin-encapsulated thermal-sensitive liposomes coated with gold nanoparticles for enhanced photothermal therapy on A431 cells
description	Sijia Wang, Jing Xin, Luwei Zhang, Yicheng Zhou, Cuiping Yao, Bing Wang, Jing Wang, Zhenxi Zhang Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Institute of Biomedical Analytical Technology and Instrumentation, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China Purpose: Plasmonic nanostructure-mediated photothermal therapy (PTT) is a promising alternative therapy for the treatment of skin cancer and other diseases. However, the insufficient efficiency of PTT at irradiation levels tolerable to tissues and the limited biodegradability of nanomaterials are still crucial challenges. In this study, a novel nanosystem for PTT based on liposome–nanoparticle assemblies (LNAs) was established.Materials and methods: Thermal-sensitive liposomes (TSLs) encapsulating cantharidin (CTD) were coated with gold nanoparticles (GNPs) and used in near-infrared (NIR) illumination-triggered PTT and thermally induced disruption on A431 cells.Results: The coated GNPs disintegrated into small particles of 5–6 nm after disruption of TSLs, allowing their clearance by the liver and kidneys. CTD encapsulated in the TSLs was released into cytoplasm after PTT. The released CTD increased the apoptosis of PTT-treated tumor cells by blocking the heat shock response (HSR) and inhibiting the expression of HSP70 and BAG3 inhibiting the expression of HSP70 and BAG3 with the synergistic enhancement of CTD, the new nanosystem CTD-encapsulated TSLs coated with GNPs (CTD-TSL@GNPs) had an efficient PTT effect using clinically acceptable irradiation power (200 mW/cm2) on A431 cells.Conclusion: The developed CTD-TSL@GNPs may be a promising PTT agent for clinical skin cancer therapy. Keywords: gold nanoparticles, liposome, cantharidin, photothermal therapy, heat shock response
format	article
author	Wang SJ Xin J Zhang LW Zhou YC Yao CP Wang B Wang J Zhang ZX
author_facet	Wang SJ Xin J Zhang LW Zhou YC Yao CP Wang B Wang J Zhang ZX
author_sort	Wang SJ
title	Cantharidin-encapsulated thermal-sensitive liposomes coated with gold nanoparticles for enhanced photothermal therapy on A431 cells
title_short	Cantharidin-encapsulated thermal-sensitive liposomes coated with gold nanoparticles for enhanced photothermal therapy on A431 cells
title_full	Cantharidin-encapsulated thermal-sensitive liposomes coated with gold nanoparticles for enhanced photothermal therapy on A431 cells
title_fullStr	Cantharidin-encapsulated thermal-sensitive liposomes coated with gold nanoparticles for enhanced photothermal therapy on A431 cells
title_full_unstemmed	Cantharidin-encapsulated thermal-sensitive liposomes coated with gold nanoparticles for enhanced photothermal therapy on A431 cells
title_sort	cantharidin-encapsulated thermal-sensitive liposomes coated with gold nanoparticles for enhanced photothermal therapy on a431 cells
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/376d2018cdcf4c54a5aa31dab777d21e
work_keys_str_mv	AT wangsj cantharidinencapsulatedthermalsensitiveliposomescoatedwithgoldnanoparticlesforenhancedphotothermaltherapyona431cells AT xinj cantharidinencapsulatedthermalsensitiveliposomescoatedwithgoldnanoparticlesforenhancedphotothermaltherapyona431cells AT zhanglw cantharidinencapsulatedthermalsensitiveliposomescoatedwithgoldnanoparticlesforenhancedphotothermaltherapyona431cells AT zhouyc cantharidinencapsulatedthermalsensitiveliposomescoatedwithgoldnanoparticlesforenhancedphotothermaltherapyona431cells AT yaocp cantharidinencapsulatedthermalsensitiveliposomescoatedwithgoldnanoparticlesforenhancedphotothermaltherapyona431cells AT wangb cantharidinencapsulatedthermalsensitiveliposomescoatedwithgoldnanoparticlesforenhancedphotothermaltherapyona431cells AT wangj cantharidinencapsulatedthermalsensitiveliposomescoatedwithgoldnanoparticlesforenhancedphotothermaltherapyona431cells AT zhangzx cantharidinencapsulatedthermalsensitiveliposomescoatedwithgoldnanoparticlesforenhancedphotothermaltherapyona431cells
_version_	1718398476257067008

Cantharidin-encapsulated thermal-sensitive liposomes coated with gold nanoparticles for enhanced photothermal therapy on A431 cells

Ejemplares similares