Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting
Arsenic resistance protein 2 (ARS2) plays an important role in nuclear RNA metabolism and interacts with the nuclear cap-binding complex (CBC). Here the authors present the human ARS2 structure and identify regions important for its interactions with binding partners supporting that mutually exclusi...
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Nature Portfolio
2018
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oai:doaj.org-article:37723f35668a4c859bee5cfff4a955b92021-12-02T16:49:49ZStructural analysis of human ARS2 as a platform for co-transcriptional RNA sorting10.1038/s41467-018-04142-72041-1723https://doaj.org/article/37723f35668a4c859bee5cfff4a955b92018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04142-7https://doaj.org/toc/2041-1723Arsenic resistance protein 2 (ARS2) plays an important role in nuclear RNA metabolism and interacts with the nuclear cap-binding complex (CBC). Here the authors present the human ARS2 structure and identify regions important for its interactions with binding partners supporting that mutually exclusive higher order CBC-ARS2 complexes are formed.Wiebke Manuela SchulzeFrank SteinMandy RettelMax NanaoStephen CusackNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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Science Q Wiebke Manuela Schulze Frank Stein Mandy Rettel Max Nanao Stephen Cusack Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting |
description |
Arsenic resistance protein 2 (ARS2) plays an important role in nuclear RNA metabolism and interacts with the nuclear cap-binding complex (CBC). Here the authors present the human ARS2 structure and identify regions important for its interactions with binding partners supporting that mutually exclusive higher order CBC-ARS2 complexes are formed. |
format |
article |
author |
Wiebke Manuela Schulze Frank Stein Mandy Rettel Max Nanao Stephen Cusack |
author_facet |
Wiebke Manuela Schulze Frank Stein Mandy Rettel Max Nanao Stephen Cusack |
author_sort |
Wiebke Manuela Schulze |
title |
Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting |
title_short |
Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting |
title_full |
Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting |
title_fullStr |
Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting |
title_full_unstemmed |
Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting |
title_sort |
structural analysis of human ars2 as a platform for co-transcriptional rna sorting |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/37723f35668a4c859bee5cfff4a955b9 |
work_keys_str_mv |
AT wiebkemanuelaschulze structuralanalysisofhumanars2asaplatformforcotranscriptionalrnasorting AT frankstein structuralanalysisofhumanars2asaplatformforcotranscriptionalrnasorting AT mandyrettel structuralanalysisofhumanars2asaplatformforcotranscriptionalrnasorting AT maxnanao structuralanalysisofhumanars2asaplatformforcotranscriptionalrnasorting AT stephencusack structuralanalysisofhumanars2asaplatformforcotranscriptionalrnasorting |
_version_ |
1718383208671739904 |