Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting

Arsenic resistance protein 2 (ARS2) plays an important role in nuclear RNA metabolism and interacts with the nuclear cap-binding complex (CBC). Here the authors present the human ARS2 structure and identify regions important for its interactions with binding partners supporting that mutually exclusi...

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Autores principales: Wiebke Manuela Schulze, Frank Stein, Mandy Rettel, Max Nanao, Stephen Cusack
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/37723f35668a4c859bee5cfff4a955b9
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spelling oai:doaj.org-article:37723f35668a4c859bee5cfff4a955b92021-12-02T16:49:49ZStructural analysis of human ARS2 as a platform for co-transcriptional RNA sorting10.1038/s41467-018-04142-72041-1723https://doaj.org/article/37723f35668a4c859bee5cfff4a955b92018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04142-7https://doaj.org/toc/2041-1723Arsenic resistance protein 2 (ARS2) plays an important role in nuclear RNA metabolism and interacts with the nuclear cap-binding complex (CBC). Here the authors present the human ARS2 structure and identify regions important for its interactions with binding partners supporting that mutually exclusive higher order CBC-ARS2 complexes are formed.Wiebke Manuela SchulzeFrank SteinMandy RettelMax NanaoStephen CusackNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Wiebke Manuela Schulze
Frank Stein
Mandy Rettel
Max Nanao
Stephen Cusack
Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting
description Arsenic resistance protein 2 (ARS2) plays an important role in nuclear RNA metabolism and interacts with the nuclear cap-binding complex (CBC). Here the authors present the human ARS2 structure and identify regions important for its interactions with binding partners supporting that mutually exclusive higher order CBC-ARS2 complexes are formed.
format article
author Wiebke Manuela Schulze
Frank Stein
Mandy Rettel
Max Nanao
Stephen Cusack
author_facet Wiebke Manuela Schulze
Frank Stein
Mandy Rettel
Max Nanao
Stephen Cusack
author_sort Wiebke Manuela Schulze
title Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting
title_short Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting
title_full Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting
title_fullStr Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting
title_full_unstemmed Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting
title_sort structural analysis of human ars2 as a platform for co-transcriptional rna sorting
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/37723f35668a4c859bee5cfff4a955b9
work_keys_str_mv AT wiebkemanuelaschulze structuralanalysisofhumanars2asaplatformforcotranscriptionalrnasorting
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AT mandyrettel structuralanalysisofhumanars2asaplatformforcotranscriptionalrnasorting
AT maxnanao structuralanalysisofhumanars2asaplatformforcotranscriptionalrnasorting
AT stephencusack structuralanalysisofhumanars2asaplatformforcotranscriptionalrnasorting
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