MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity

MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity

IL-17 is a pro-inflammatory molecule that can also regulate neural circuit function. Here the authors use C. elegans to show that the paracaspase MALT-1 lies downstream of IL-17 signaling and regulates many aspects of C. elegans biology, including escape behavior, associative learning, immunity and...

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Auteurs principaux: Sean M. Flynn, Changchun Chen, Murat Artan, Stephen Barratt, Alastair Crisp, Geoffrey M. Nelson, Sew-Yeu Peak-Chew, Farida Begum, Mark Skehel, Mario de Bono
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Science
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Accès en ligne:https://doaj.org/article/377402b6f41e4c2d90a5764edd0f5adf
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Résumé:IL-17 is a pro-inflammatory molecule that can also regulate neural circuit function. Here the authors use C. elegans to show that the paracaspase MALT-1 lies downstream of IL-17 signaling and regulates many aspects of C. elegans biology, including escape behavior, associative learning, immunity and longevity.

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